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Topics in Current Chemistry (2020) 378:16
4 Outlook
Through each section of this review we have demonstrated how using tertiary amine
Lewis base catalysts in combination with Lewis acid or transition metal catalysts
can be harnessed for the development of enantioselective chemical synthesis reactions. In each illustrated case, two catalysts were absolutely necessary for control
over reactivity and/or stereochemical generation. This amply demonstrates the enormous potential of uniting distinct catalyst events and points to many future exciting
developments in enantioselective cooperative catalysis.
References
1. Beller M, Bolm C (2004) Transition metals for organic synthesis: building blocks and fine chemicals. Wiley, Weinheim
2. Peters R (2015) Cooperative catalysis: designing efficient catalysts for synthesis. Wiley, Weinheim
3. Chauhan P, Mahajan S, Enders D (2017) Acc Chem Res 50:2809–2821
Scheme 35 Proposed mechanism and stereochemical model for the asymmetric α-amination of esters
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