N
X
C
Hal
O
N
S
P Si
Natural
Products
Solvents
C
C
C
C C
C
231
5.11 Carbonyl Compounds
231
5.11.5 Amides and Lactams
Amide Protons (δ in ppm, J in Hz)
Higher values in DMSO or with H bond acceptors in the vicinity.
O
O
6.25
6.31
7.33
7.48
O
O
≈1.6
5–7
6–8.5
7.5–10
2.50
R: alk or ar
R: alk or ar
R: alk or ar
O
H
H
H
H H
H
O
O
O
7.46
7.64
O
O
O
O
O
O
O
O
H
H
H
O
O
H
H
H
3.77
3.92
4.36
1.38
1.37
5.22
8.04
8.05
7.99
7.22
7.44
7.28
8.21
7.43
7.41
7.37
7.52
7.55
7.52
3.56
3.31
6.05
≈1.6
7.10
4.09
4.44
6.18
7.59
4.91
2.49
2.26
4.32
4.29
4.21
1.30
6.12
6.13
6.41
6.37
5.83
5.81
O
O
O
O
O
O
a
b
c
d
f
e
2 J ab -17.5
3 J ac 9.5
3 J ad 6.9
4 J ae 0.3
4 J af -0.5
3 J ab 9.4
4 J ac 1.5
5 J ad 1.3
3 J bc 6.3
4 J bd 2.4
3 J cd 5.0
2 J cd -12.7
3 J ce 7.9
3 J cf 6.3
2 J ef -8.8
a
b
c
d
R
O
NH 2
R
O
N
H
R
O
N
H
alk