Fig. 5
SMNPs NIR-II
fluorophores and imaging in vivo. (a) Schematic illustration of the CQS1000 NIR-II
fluorophore and TEM imaging of the NIR-II
particles. (b) Fluorescence images of the vasculature of hindlimb in mice using ICG (NIR-I) and CQS1000 (NIR-II), showing the NIR-II images with the higher
SBR. (c) In vivo dynamic assessment of angiogenesis development of tumor. (d) Chemical structure of IR-FGP with D–A–D architecture containing two PEG
chains and two azide groups for biocompatibility and bioconjugation. (e) Scheme of the conjugation route between IR-FGP and proteins by click chemistry. (f)
Multicolor 2D/3D staining in NIR-II windows (800–1,700 nm): (i) Magnified multicolor brain tissue staining with higher resolution; (ii) confocal scanning from
cross sections of brain tissue; (iii) three-color 3D rendering of nucleus, neuron, and vessel channels obtained with NIR-I/II confocal microscopy. (a–c) Reprinted
(adapted) with permission from Ref. [16], Copyright 2017, Wiley-VCH Verlag GmbH & Co. KGaA. (d–f) Reprinted (adapted) with permission from Ref. [14],
Copyright 2017, National Academy of Sciences
90
S. He and Z. Cheng
SMNPs NIR-II
fluorophores and imaging in vivo. (a) Schematic illustration of the CQS1000 NIR-II
fluorophore and TEM imaging of the NIR-II
particles. (b) Fluorescence images of the vasculature of hindlimb in mice using ICG (NIR-I) and CQS1000 (NIR-II), showing the NIR-II images with the higher
SBR. (c) In vivo dynamic assessment of angiogenesis development of tumor. (d) Chemical structure of IR-FGP with D–A–D architecture containing two PEG
chains and two azide groups for biocompatibility and bioconjugation. (e) Scheme of the conjugation route between IR-FGP and proteins by click chemistry. (f)
Multicolor 2D/3D staining in NIR-II windows (800–1,700 nm): (i) Magnified multicolor brain tissue staining with higher resolution; (ii) confocal scanning from
cross sections of brain tissue; (iii) three-color 3D rendering of nucleus, neuron, and vessel channels obtained with NIR-I/II confocal microscopy. (a–c) Reprinted
(adapted) with permission from Ref. [16], Copyright 2017, Wiley-VCH Verlag GmbH & Co. KGaA. (d–f) Reprinted (adapted) with permission from Ref. [14],
Copyright 2017, National Academy of Sciences
90
S. He and Z. Cheng