79. Fujiwara M, Mizukami T, Suzuki A, Fukamizu H (2009) Sentinel lymph node detection in
skin cancer patients using real-time fluorescence navigation with indocyanine green: preliminary experience. J Plast Reconstr Aesthet Surg 62:E373–E378
80. van der Vorst JR et al (2013) Dose optimization for near-infrared fluorescence sentinel lymph
node mapping in patients with melanoma. Br J Dermatol 168:93–98
81. van Dam GM et al (2011) Intraoperative tumor-specific fluorescence imaging in ovarian
cancer by folate receptor-alpha targeting: first in-human results. Nat Med 17:1315–U202
82. Tsujino Y, Mizumoto K, Matsuzaka Y, Niihara H, Morita E (2009) Fluorescence navigation
with indocyanine green for detecting sentinel nodes in extramammary Paget’s disease and
squamous cell carcinoma. J Dermatol 36:90–94
83. Yokoyama N et al (2012) Real-time detection of hepatic micrometastases from pancreatic
cancer by intraoperative fluorescence imaging preliminary results of a prospective study.
Cancer 118:2813–2819
84. Suzuki T et al (2013) Cadherin 13 overexpression as an important factor related to the absence
of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma laboratory investigation. J Neurosurg 119:1331–1339
85. Loja MN et al (2013) Optical molecular imaging detects changes in extracellular pH with the
development of head and neck cancer. Int J Cancer 132:1613–1623
86. Sevick-Muraca EM (2012) Translation of near-infrared fluorescence imaging technologies:
emerging clinical applications. Annu Rev Med 63:217–231
87. Wapnir I et al (2014) Intraoperative imaging of nipple perfusion patterns and ischemic
complications in nipple-sparing mastectomies. Ann Surg Oncol 21:100–106
88. Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJH, Frangioni JV (2013)
Image-guided cancer surgery using near-infrared fluorescence. Nat Rev Clin Oncol
10:507–518
89. van der Vorst JR et al (2012) 46. Near-infrared fluorescence sentinel lymph node mapping of
the oral cavity in head and neck cancer patients. Eur J Surg Oncol 38:745
90. Chi C et al (2014) Intraoperative imaging-guided Cancer surgery: from current fluorescence
molecular imaging methods to future multi-modality imaging technology. Theranostics
4:1072–1084
91. Nguyen QT, Tsien RY (2013) Fluorescence-guided surgery with live molecular navigation – a
new cutting edge. Nat Rev Cancer 13:653–662
92. He L, Yang X, Xu K, Kong X, Lin W (2017) A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and
hydrogen sulfide in living cells. Chem Sci 8:6257–6265
93. Zhang L et al (2016) A highly selective and sensitive near-infrared fluorescent probe for
imaging of hydrogen sulphide in living cells and mice. Sci Rep 6:18868
94. Xie X, Yin C, Yue Y, Chao J, Huo F (2018) Fluorescent probe detect distinguishly sulfite/
hydrogen sulfide and thiol via two emission channels in vivo. Sens Actuators B Chem
277:647–653
95. Yin J et al (2016) Correction to ‘cyanine-based fluorescent probe for highly selective detection
of glutathione in cell cultures and live mouse tissues’. J Am Chem Soc 138:7442
96. Zhang X et al (2019) Mitochondria-targeting near-infrared ratiometric fluorescent probe for
selective imaging of cysteine in orthotopic lung cancer mice. Sens Actuators B Chem
282:69–77
97. Chen X, Ko S-K, Kim MJ, Shin I, Yoon J (2010) A thiol-specific fluorescent probe and its
application for bioimaging. Chem Commun 46:2751–2753
98. Zhu B et al (2010) A colorimetric and ratiometric fluorescent probe for thiols and its
bioimaging applications. Chem Commun 46:5710–5712
99. Lim CS et al (2011) Ratiometric detection of mitochondrial thiols with a two-photon fluorescent
probe. J Am Chem Soc 133:11132–11135
100. Kellum JA, Song M, Li J (2004) Science review: extracellular acidosis and the immune
response: clinical and physiologic implications. Crit Care 8:331
Organic Fluorescent Probes for Diagnostics and Bio-Imaging
51
skin cancer patients using real-time fluorescence navigation with indocyanine green: preliminary experience. J Plast Reconstr Aesthet Surg 62:E373–E378
80. van der Vorst JR et al (2013) Dose optimization for near-infrared fluorescence sentinel lymph
node mapping in patients with melanoma. Br J Dermatol 168:93–98
81. van Dam GM et al (2011) Intraoperative tumor-specific fluorescence imaging in ovarian
cancer by folate receptor-alpha targeting: first in-human results. Nat Med 17:1315–U202
82. Tsujino Y, Mizumoto K, Matsuzaka Y, Niihara H, Morita E (2009) Fluorescence navigation
with indocyanine green for detecting sentinel nodes in extramammary Paget’s disease and
squamous cell carcinoma. J Dermatol 36:90–94
83. Yokoyama N et al (2012) Real-time detection of hepatic micrometastases from pancreatic
cancer by intraoperative fluorescence imaging preliminary results of a prospective study.
Cancer 118:2813–2819
84. Suzuki T et al (2013) Cadherin 13 overexpression as an important factor related to the absence
of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma laboratory investigation. J Neurosurg 119:1331–1339
85. Loja MN et al (2013) Optical molecular imaging detects changes in extracellular pH with the
development of head and neck cancer. Int J Cancer 132:1613–1623
86. Sevick-Muraca EM (2012) Translation of near-infrared fluorescence imaging technologies:
emerging clinical applications. Annu Rev Med 63:217–231
87. Wapnir I et al (2014) Intraoperative imaging of nipple perfusion patterns and ischemic
complications in nipple-sparing mastectomies. Ann Surg Oncol 21:100–106
88. Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJH, Frangioni JV (2013)
Image-guided cancer surgery using near-infrared fluorescence. Nat Rev Clin Oncol
10:507–518
89. van der Vorst JR et al (2012) 46. Near-infrared fluorescence sentinel lymph node mapping of
the oral cavity in head and neck cancer patients. Eur J Surg Oncol 38:745
90. Chi C et al (2014) Intraoperative imaging-guided Cancer surgery: from current fluorescence
molecular imaging methods to future multi-modality imaging technology. Theranostics
4:1072–1084
91. Nguyen QT, Tsien RY (2013) Fluorescence-guided surgery with live molecular navigation – a
new cutting edge. Nat Rev Cancer 13:653–662
92. He L, Yang X, Xu K, Kong X, Lin W (2017) A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine/homocysteine, glutathione, and
hydrogen sulfide in living cells. Chem Sci 8:6257–6265
93. Zhang L et al (2016) A highly selective and sensitive near-infrared fluorescent probe for
imaging of hydrogen sulphide in living cells and mice. Sci Rep 6:18868
94. Xie X, Yin C, Yue Y, Chao J, Huo F (2018) Fluorescent probe detect distinguishly sulfite/
hydrogen sulfide and thiol via two emission channels in vivo. Sens Actuators B Chem
277:647–653
95. Yin J et al (2016) Correction to ‘cyanine-based fluorescent probe for highly selective detection
of glutathione in cell cultures and live mouse tissues’. J Am Chem Soc 138:7442
96. Zhang X et al (2019) Mitochondria-targeting near-infrared ratiometric fluorescent probe for
selective imaging of cysteine in orthotopic lung cancer mice. Sens Actuators B Chem
282:69–77
97. Chen X, Ko S-K, Kim MJ, Shin I, Yoon J (2010) A thiol-specific fluorescent probe and its
application for bioimaging. Chem Commun 46:2751–2753
98. Zhu B et al (2010) A colorimetric and ratiometric fluorescent probe for thiols and its
bioimaging applications. Chem Commun 46:5710–5712
99. Lim CS et al (2011) Ratiometric detection of mitochondrial thiols with a two-photon fluorescent
probe. J Am Chem Soc 133:11132–11135
100. Kellum JA, Song M, Li J (2004) Science review: extracellular acidosis and the immune
response: clinical and physiologic implications. Crit Care 8:331
Organic Fluorescent Probes for Diagnostics and Bio-Imaging
51