Sciences (grant number XDB32030200, XDB01030200), and Chinese Academy of Sciences (grant
number QYZDJ-SSW-JSC005).
Ethical Approval: This chapter does not contain any studies with human participants or animals
performed by any of the authors.
Conflict of Interest: The authors declare no conflict of interest.
References
1. Corrêa IR Jr (2014) Live-cell reporters for fluorescence imaging. Curr Opin Chem Biol
20:36–45
2. Dean KM, Palmer AE (2014) Advances in fluorescence labeling strategies for dynamic
cellular imaging. Nat Chem Biol 10(7):512–523
3. Hu Z, Qu Y, Wang K, Zhang X, Zha J, Song T, Bao C, Liu H, Wang Z, Wang J, Liu Z, Liu H,
Tian J (2015) In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. Nat Commun 6:7560
4. de Jong M, Essers J, van Weerden WM (2014) Imaging preclinical tumour models: improving
translational power. Nat Rev Cancer 14(7):481–493
5. Chen X, Wang F, Hyun JY, Wei T, Qiang J, Ren X, Shin I, Yoon J (2016) Recent progress in
the development of fluorescent, luminescent and colorimetric probes for detection of reactive
oxygen and nitrogen species. Chem Soc Rev 45(10):2976–3016
6. Chi C, Du Y, Ye J, Kou D, Qiu J, Wang J, Tian J, Chen X (2014) Intraoperative imagingguided cancer surgery: from current fluorescence molecular imaging methods to future multimodality imaging technology. Theranostics 4(11):1072–1084
7. Gao M, Yu F, Lv C, Choo J, Chen L (2017) Fluorescent chemical probes for accurate tumor
diagnosis and targeting therapy. Chem Soc Rev 46(8):2237–2271
8. Jiao X, Li Y, Niu J, Xie X, Wang X, Tang B (2018) Small-molecule fluorescent probes for
imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems.
Anal Chem 90(1):533–555
9. Liu JN, Bu W, Shi J (2017) Chemical design and synthesis of functionalized probes for
imaging and treating tumor hypoxia. Chem Rev 117(9):6160–6224
10. Ding F, Zhan Y, Lu X, Sun Y (2018) Recent advances in near-infrared II fluorophores for
multifunctional biomedical imaging. Chem Sci 9(19):4370–4380
11. He SQ, Song J, Qu JL, Cheng Z (2018) Crucial breakthrough of second near-infrared
biological window fluorophores: design and synthesis toward multimodal imaging and
theranostics. Chem Soc Rev 47(12):4258–4278
12. Lavis LD, Raines RT (2014) Bright building blocks for chemical biology. ACS Chem Biol 9
(4):855–866
13. Gonçalves MS (2009) Fluorescent labeling of biomolecules with organic probes. Chem Rev
109(1):190–212
14. Zheng Y, Ji S, Czerwinski A, Valenzuela F, Pennington M, Liu S (2014) FITC-conjugated
cyclic RGD peptides as fluorescent probes for staining integrin αvβ3/αvβ5 in tumor tissues.
Bioconjug Chem 25(11):1925–1941
15. Bartholomä MD, Gottumukkala V, Zhang S, Baker A, Dunning P, Fahey FH, Treves ST,
Packard AB (2012) Effect of the prosthetic group on the pharmacologic properties of
18F-labeled rhodamine B, a potential myocardial perfusion agent for positron emission
tomography (PET). J Med Chem 55(24):11004–11012
16. Sun T, Guan X, Zheng M, Jing X, Xie Z (2015) Mitochondria-localized fluorescent BODIPYplatinum conjugate. ACS Med Chem Lett 6(4):430–433
17. Fei XN, Gu YC (2009) Progress in modifications and applications of fluorescent dye probe.
Prog Nat Sci 19(1):1–7
Fluorescence Molecular Imaging of Medicinal Chemistry in Cancer
25
number QYZDJ-SSW-JSC005).
Ethical Approval: This chapter does not contain any studies with human participants or animals
performed by any of the authors.
Conflict of Interest: The authors declare no conflict of interest.
References
1. Corrêa IR Jr (2014) Live-cell reporters for fluorescence imaging. Curr Opin Chem Biol
20:36–45
2. Dean KM, Palmer AE (2014) Advances in fluorescence labeling strategies for dynamic
cellular imaging. Nat Chem Biol 10(7):512–523
3. Hu Z, Qu Y, Wang K, Zhang X, Zha J, Song T, Bao C, Liu H, Wang Z, Wang J, Liu Z, Liu H,
Tian J (2015) In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. Nat Commun 6:7560
4. de Jong M, Essers J, van Weerden WM (2014) Imaging preclinical tumour models: improving
translational power. Nat Rev Cancer 14(7):481–493
5. Chen X, Wang F, Hyun JY, Wei T, Qiang J, Ren X, Shin I, Yoon J (2016) Recent progress in
the development of fluorescent, luminescent and colorimetric probes for detection of reactive
oxygen and nitrogen species. Chem Soc Rev 45(10):2976–3016
6. Chi C, Du Y, Ye J, Kou D, Qiu J, Wang J, Tian J, Chen X (2014) Intraoperative imagingguided cancer surgery: from current fluorescence molecular imaging methods to future multimodality imaging technology. Theranostics 4(11):1072–1084
7. Gao M, Yu F, Lv C, Choo J, Chen L (2017) Fluorescent chemical probes for accurate tumor
diagnosis and targeting therapy. Chem Soc Rev 46(8):2237–2271
8. Jiao X, Li Y, Niu J, Xie X, Wang X, Tang B (2018) Small-molecule fluorescent probes for
imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems.
Anal Chem 90(1):533–555
9. Liu JN, Bu W, Shi J (2017) Chemical design and synthesis of functionalized probes for
imaging and treating tumor hypoxia. Chem Rev 117(9):6160–6224
10. Ding F, Zhan Y, Lu X, Sun Y (2018) Recent advances in near-infrared II fluorophores for
multifunctional biomedical imaging. Chem Sci 9(19):4370–4380
11. He SQ, Song J, Qu JL, Cheng Z (2018) Crucial breakthrough of second near-infrared
biological window fluorophores: design and synthesis toward multimodal imaging and
theranostics. Chem Soc Rev 47(12):4258–4278
12. Lavis LD, Raines RT (2014) Bright building blocks for chemical biology. ACS Chem Biol 9
(4):855–866
13. Gonçalves MS (2009) Fluorescent labeling of biomolecules with organic probes. Chem Rev
109(1):190–212
14. Zheng Y, Ji S, Czerwinski A, Valenzuela F, Pennington M, Liu S (2014) FITC-conjugated
cyclic RGD peptides as fluorescent probes for staining integrin αvβ3/αvβ5 in tumor tissues.
Bioconjug Chem 25(11):1925–1941
15. Bartholomä MD, Gottumukkala V, Zhang S, Baker A, Dunning P, Fahey FH, Treves ST,
Packard AB (2012) Effect of the prosthetic group on the pharmacologic properties of
18F-labeled rhodamine B, a potential myocardial perfusion agent for positron emission
tomography (PET). J Med Chem 55(24):11004–11012
16. Sun T, Guan X, Zheng M, Jing X, Xie Z (2015) Mitochondria-localized fluorescent BODIPYplatinum conjugate. ACS Med Chem Lett 6(4):430–433
17. Fei XN, Gu YC (2009) Progress in modifications and applications of fluorescent dye probe.
Prog Nat Sci 19(1):1–7
Fluorescence Molecular Imaging of Medicinal Chemistry in Cancer
25