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55. Verbeek FP, Tummers QR, Rietbergen DD, Peters AA, Schaafsma BE, van de Velde CJ,
Frangioni JV, van Leeuwen FW, Gaarenstroom KN, Vahrmeijer AL (2015) Sentinel lymph
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56. van Leeuwen FWB, Winter A, van Der Poel HG, Eiber M, Suardi N, Graefen M,
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58. Ribatti D, Ranieri G, Basile A, Azzariti A, Paradiso A, Vacca A (2012) Tumor endothelial
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59. Mahmood U, Weissleder R (2003) Near-infrared optical imaging of proteases in cancer. Mol
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60. Robertson R (2009) Optical imaging of Cerenkov light generation from positron-emitting
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61. Shaffer TM, Pratt EC, Grimm J (2017) Utilizing the power of Cerenkov light with nanotechnology. Nat Nanotechnol 12:106–117
62. Bolotovskii BM (2009) Vavilov – Cherenkov radiation: its discovery and application. PhysicsUspekhi 52:1099–1110
63. Das S, Thorek DLJ, Grimm J (2014) Cerenkov imaging. Adv Cancer Res 124:213–234
64. Thorek DLJ, Robertson R, Bacchus WA, Hahn J, Rothberg J, Beattie BJ, Grimm J (2012)
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65. Ruggiero A, Holland JP, Lewis JS, Grimm J (2010) Cerenkov luminescence imaging of medical
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66. Das S, Haedicke K, Grimm J (2018) Cerenkov-activated sticky tag for in vivo fluorescence
imaging. J Nucl Med 59(1):58–65
67. Pratt EC, Shaffer TM, Grimm J (2016) Nanoparticles and radiotracers: advances toward
radionanomedicine. WIREs Nanomed Nanobiotechnol 8:872–890
68. Tamura R, Pratt EC, Grimm J (2018) Innovations in nuclear imaging instrumentation: Cerenkov
imaging. Semin Nucl Med 48:359–366
69. Calvaresi EC, Hergenrother PJ (2013) Glucose conjugation for the specific targeting and
treatment of cancer. Chem Sci 4:2319–2333
70. Liu H, Ren G, Miao Z, Zhang X, Tang X, Han P, Sanjiv S (2010) Molecular optical imaging
with radioactive probes. PLoS One 5:e9470
71. Lohrmann C, Zhang H, Thorek DLJ, Desai P, Zanzonico PB, O’Donoghue J, Irwin CP,
Reiner T, Grimm J, Weber WA (2015) Cerenkov luminescence imaging for radiation dose
calculation of a 90y-labeled gastrin-releasing peptide receptor antagonist. J Nucl Med 56
(5):805–811
72. D’Souza JW, Hensley H, Doss M, Beigarten C, Torgov M, Olafsen T, Yu JQ, Robinson MK
(2017) Cerenkov luminescence imaging as a modality to evaluate antibody-based pet radiotracers. J Nucl Med 58(1):175–180
73. Dothager RS, Goiffon RJ, Jackson E, Harpstrite S, Piwnica-Worms D (2010) Cerenkov
radiation energy transfer (CRET) imaging: a novel method for optical imaging of pet isotopes
in biological systems. PLoS One 5(10):e13300
222
E. P. Stater et al.
sentinel lymph node detection in gastric cancer and carcinoembryonic antigen targeted
fluorescent-guided surgery in colorectal and pancreatic cancer. J Surg Oncol 118(2):315–323
54. Handgraaf HJ, Boogerd LS, Verbeek FP, Tummers QR, Hardwick JC, Baeten CI, Frangioni JV,
van de Velde CJ, Vahrmeijer AL (2016) Intraoperative fluorescence imaging to localize tumors
and sentinel lymph nodes in rectal cancer. Minim Invasive Ther Allied Technol 25(1):48–53
55. Verbeek FP, Tummers QR, Rietbergen DD, Peters AA, Schaafsma BE, van de Velde CJ,
Frangioni JV, van Leeuwen FW, Gaarenstroom KN, Vahrmeijer AL (2015) Sentinel lymph
node biopsy in vulvar cancer using combined radioactive and fluorescence guidance. Int J
Gynecol Cancer 25(6):1086–1093
56. van Leeuwen FWB, Winter A, van Der Poel HG, Eiber M, Suardi N, Graefen M,
Wawroschek F, Maurer T (2019) Technologies for image-guided surgery for managing lymphatic metastases in prostate cancer. Nat Rev Urol 16:159–171
57. Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG
(2009) Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 6
(6):327–338
58. Ribatti D, Ranieri G, Basile A, Azzariti A, Paradiso A, Vacca A (2012) Tumor endothelial
markers as a target in cancer. Expert Opin Ther Targets 16(12):1215–1225
59. Mahmood U, Weissleder R (2003) Near-infrared optical imaging of proteases in cancer. Mol
Cancer Ther 2(5):489–496
60. Robertson R (2009) Optical imaging of Cerenkov light generation from positron-emitting
radiotracers. Phys Med Biol 54:N355–N365
61. Shaffer TM, Pratt EC, Grimm J (2017) Utilizing the power of Cerenkov light with nanotechnology. Nat Nanotechnol 12:106–117
62. Bolotovskii BM (2009) Vavilov – Cherenkov radiation: its discovery and application. PhysicsUspekhi 52:1099–1110
63. Das S, Thorek DLJ, Grimm J (2014) Cerenkov imaging. Adv Cancer Res 124:213–234
64. Thorek DLJ, Robertson R, Bacchus WA, Hahn J, Rothberg J, Beattie BJ, Grimm J (2012)
Cerenkov imaging – a new modality for molecular imaging. Am J Nucl Med Mol Imaging
2:163–173
65. Ruggiero A, Holland JP, Lewis JS, Grimm J (2010) Cerenkov luminescence imaging of medical
isotopes. J Nucl Med 51:1123–1130
66. Das S, Haedicke K, Grimm J (2018) Cerenkov-activated sticky tag for in vivo fluorescence
imaging. J Nucl Med 59(1):58–65
67. Pratt EC, Shaffer TM, Grimm J (2016) Nanoparticles and radiotracers: advances toward
radionanomedicine. WIREs Nanomed Nanobiotechnol 8:872–890
68. Tamura R, Pratt EC, Grimm J (2018) Innovations in nuclear imaging instrumentation: Cerenkov
imaging. Semin Nucl Med 48:359–366
69. Calvaresi EC, Hergenrother PJ (2013) Glucose conjugation for the specific targeting and
treatment of cancer. Chem Sci 4:2319–2333
70. Liu H, Ren G, Miao Z, Zhang X, Tang X, Han P, Sanjiv S (2010) Molecular optical imaging
with radioactive probes. PLoS One 5:e9470
71. Lohrmann C, Zhang H, Thorek DLJ, Desai P, Zanzonico PB, O’Donoghue J, Irwin CP,
Reiner T, Grimm J, Weber WA (2015) Cerenkov luminescence imaging for radiation dose
calculation of a 90y-labeled gastrin-releasing peptide receptor antagonist. J Nucl Med 56
(5):805–811
72. D’Souza JW, Hensley H, Doss M, Beigarten C, Torgov M, Olafsen T, Yu JQ, Robinson MK
(2017) Cerenkov luminescence imaging as a modality to evaluate antibody-based pet radiotracers. J Nucl Med 58(1):175–180
73. Dothager RS, Goiffon RJ, Jackson E, Harpstrite S, Piwnica-Worms D (2010) Cerenkov
radiation energy transfer (CRET) imaging: a novel method for optical imaging of pet isotopes
in biological systems. PLoS One 5(10):e13300
222
E. P. Stater et al.