Top Med Chem (2020) 34: 203–224
DOI: 10.1007/7355_2019_84
© Springer Nature Switzerland AG 2019
Published online: 8 February 2020
The Present and Future of Optical Imaging
Technologies in the Clinic: Diagnosis
and Therapy
Evan P. Stater, Magdalena Skubal, Ryo Tamura, and Jan Grimm
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
2 Diagnostic Endoscopic Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
3 Optical Imaging in Interventional Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
4 Cerenkov Luminescence Imaging and Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Abstract Medical techniques based upon optical imaging technologies are
important tools in clinical practice. The use of optical imaging in medical diagnosis
is well established, and a large array of techniques are in current use, such as white
light endoscopy, autofluorescence imaging, and optical coherence tomography. The
applications of these techniques are expanding, and newer imaging technologies are
becoming available to address problems and limitations associated with existing
methods. Beyond diagnostics, optical imaging is increasingly a useful component
of interventional medical procedures, such as image-guided surgery. In procedures
such as surgical tumor resection, fluorescence imaging can aid surgeons in improving both accuracy and completeness of removal. Relevant to both diagnostic and
therapeutic applications, Cerenkov luminescence imaging is a potential clinical
technique which relies upon generation of visible-spectrum light by beta particles
in a dielectric medium; this method could allow for coupling of a multimodal optical
component to existing molecular imaging techniques, such as positron emission
tomography, and also provide a means of monitoring distribution of administered
clinically relevant radionuclides such as lutetium-177.
E. P. Stater
Weill Cornell Medicine, New York, NY, USA
M. Skubal and R. Tamura
Memorial Sloan Kettering Cancer Center, New York, NY, USA
J. Grimm (*)
Weill Cornell Medicine, New York, NY, USA
Memorial Sloan Kettering Cancer Center, New York, NY, USA
e-mail: grimmj@mskcc.org
DOI: 10.1007/7355_2019_84
© Springer Nature Switzerland AG 2019
Published online: 8 February 2020
The Present and Future of Optical Imaging
Technologies in the Clinic: Diagnosis
and Therapy
Evan P. Stater, Magdalena Skubal, Ryo Tamura, and Jan Grimm
Contents
1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
2 Diagnostic Endoscopic Imaging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
3 Optical Imaging in Interventional Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211
4 Cerenkov Luminescence Imaging and Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219
Abstract Medical techniques based upon optical imaging technologies are
important tools in clinical practice. The use of optical imaging in medical diagnosis
is well established, and a large array of techniques are in current use, such as white
light endoscopy, autofluorescence imaging, and optical coherence tomography. The
applications of these techniques are expanding, and newer imaging technologies are
becoming available to address problems and limitations associated with existing
methods. Beyond diagnostics, optical imaging is increasingly a useful component
of interventional medical procedures, such as image-guided surgery. In procedures
such as surgical tumor resection, fluorescence imaging can aid surgeons in improving both accuracy and completeness of removal. Relevant to both diagnostic and
therapeutic applications, Cerenkov luminescence imaging is a potential clinical
technique which relies upon generation of visible-spectrum light by beta particles
in a dielectric medium; this method could allow for coupling of a multimodal optical
component to existing molecular imaging techniques, such as positron emission
tomography, and also provide a means of monitoring distribution of administered
clinically relevant radionuclides such as lutetium-177.
E. P. Stater
Weill Cornell Medicine, New York, NY, USA
M. Skubal and R. Tamura
Memorial Sloan Kettering Cancer Center, New York, NY, USA
J. Grimm (*)
Weill Cornell Medicine, New York, NY, USA
Memorial Sloan Kettering Cancer Center, New York, NY, USA
e-mail: grimmj@mskcc.org