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detection of dopamine in flies, fish, and mice. Cell 174(2):481–496.e19
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for visuomotor behavior. Neuron 81(6):1328–1343
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in the nervous system. Nature 450(7166):56–62
178. Nobis M et al (2017) A RhoA-FRET biosensor mouse for intravital imaging in normal tissue
homeostasis and disease contexts. Cell Rep 21(1):274–288
179. Heppert JK et al (2016) Comparative assessment of fluorescent proteins for in vivo imaging in
an animal model system. Mol Biol Cell 27(22):3385–3394
180. Hirayama T et al (2012) Near-infrared fluorescent sensor for in vivo copper imaging in a
murine Wilson disease model. Proc Natl Acad Sci U S A 109(7):2228–2233
181. Giloh H, Sedat JW (1982) Fluorescence microscopy: reduced photobleaching of rhodamine
and fluorescein protein conjugates by n-propyl gallate. Science 217(4566):1252–1255
182. White J, Stelzer E (1999) Photobleaching GFP reveals protein dynamics inside live cells.
Trends Cell Biol 9(2):61–65
183. Dixit R, Cyr R (2003) Cell damage and reactive oxygen species production induced by
fluorescence microscopy: effect on mitosis and guidelines for non-invasive fluorescence
microscopy. Plant J 36(2):280–290
184. Niswender KD et al (1995) Quantitative imaging of green fluorescent protein in cultured cells:
comparison of microscopic techniques, use in fusion proteins and detection limits. J Microsc
180(Pt 2):109–116
185. Shaner NC, Steinbach PA, Tsien RY (2005) A guide to choosing fluorescent proteins. Nat
Methods 2(12):905–909
186. Shcherbakova DM, Verkhusha VV (2013) Near-infrared fluorescent proteins for multicolor
in vivo imaging. Nat Methods 10(8):751–754
187. Nishihara R et al (2019) Highly bright and stable NIR-BRET with blue-shifted coelenterazine
derivatives for deep-tissue imaging of molecular events in vivo. Theranostics 9(9):2646–2661
Applications of Fluorescent Protein-Based Sensors in Bioimaging
183