26. Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for
biomedical applications. Biomaterials 26:3995–4021
27. Ngwa W, Makrigiorgos GM, Berbeco RI (2012) Gold nanoparticle enhancement of stereotactic
radiosurgery for neovascular age-related macular degeneration. Phys Med Biol 57:6371–6380
28. Chattopadhyay N, Cai Z, Kwon YL, Lechtman E, Pignol JP, Reilly RM (2013) Molecularly
targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor
xenografts to X-radiation. Breast Cancer Res Treat 137:81–91
29. Hossain M, Su M (2012) Nanoparticle location and material dependent dose enhancement in
X-ray radiation therapy. J Phys Chem C Nanomater Interfaces 116:23047–23052
30. Cho SH (2005) Estimation of tumour dose enhancement due to gold nanoparticles during
typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol 50:N163–N173
31. Geng F, Song K, Xing JZ, Yuan C, Yan S, Yang Q, Chen J, Kong B (2011) Thio-glucose bound
gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer. Nanotechnology
22:285101
32. Allemann E, Brasseur N, Benrezzak O, Rousseau J, Kudrevich SV, Boyle RW, Leroux JC,
Gurny R, van Lier JE (1995) PEG-coated poly(lactic acid) nanoparticles for the delivery of
hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumours. J Pharm Pharmacol
47:382–387
33. Khlebtsov B, Panfilova E, Khanadeev V, Bibikova O, Terentyuk G, Ivanov A, Rumyantseva V,
Shilov I, Ryabova A, Loshchenov V, Khlebtsov NG (2011) Nanocomposites containing silicacoated gold-silver nanocages and Yb-2,4-dimethoxyhematoporphyrin: multifunctional capability of IR-luminescence detection, photosensitization, and photothermolysis. ACS Nano
5:7077–7089
34. Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao J, Baker CH (2013) Sensitization of
pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.
Nanomedicine 9:558–569
35. Timerbaev A, Sturup S (2012) Analytical approaches for assaying metallodrugs in biological
samples: recent methodological developments and future trends. Curr Drug Metab 13:272–283
36. Geraki K, Farquharson MJ, Bradley DA (2002) Concentrations of Fe, Cu and Zn in breast
tissue: a synchrotron XRF study. Phys Med Biol 47:2327
37. Costello LC, Franklin RB (1998) Novel role of zinc in the regulation of prostate citrate
metabolism and its implications in prostate cancer. Prostate 35:285–296
38. Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS,
Fineberg S, Pestell RG, Carrasco N (2000) The mammary gland iodide transporter is expressed
during lactation and in breast cancer. Nat Med 6:871–878
39. Naczynski DJ, Sun C, Turkcan S, Jenkins C, Koh AL, Ikeda D, Pratx G, Xing L (2015) X-rayinduced shortwave infrared biomedical imaging using rare-earth nanoprobes. Nano Lett
15:96–102
40. Chen D, Zhu S, Yi H, Zhang X, Chen D, Liang J, Tian J (2013) Cone beam x-ray luminescence
computed tomography: a feasibility study. Med Phys 40:031111
41. Yi Z, Lu W, Xu Y, Yang J, Deng L, Qian C, Zeng T, Wang H, Rao L, Liu H, Zeng S (2014)
PEGylated NaLuF4: Yb/Er upconversion nanophosphors for in vivo synergistic fluorescence/
X-ray bioimaging and long-lasting, real-time tracking. Biomaterials 35:9689–9697
42. Cong W, Wang C, Wang G (2014) Stored luminescence computed tomography. Appl Optics
53:5672–5676
43. Carpenter CM, Sun C, Pratx G, Rao R, Xing L (2010) Hybrid x-ray/optical luminescence
imaging: characterization of experimental conditions. Med Phys 37:4011–4018
44. Pratx G, Carpenter CM, Sun C, Rao RP, Xing L (2010) Tomographic molecular imaging of xray-excitable nanoparticles. Opt Lett 35:3345–3347
45. Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, Jerin J, Young J, Byars L,
Nutt R (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41:1369–1379
46. Schillaci O (2005) Hybrid SPECT/CT: a new era for SPECT imaging? Eur J Nucl Med Mol
Imaging 32:521–524
X-Ray Excited Fluorescent Materials for Medical Application
147
biomedical applications. Biomaterials 26:3995–4021
27. Ngwa W, Makrigiorgos GM, Berbeco RI (2012) Gold nanoparticle enhancement of stereotactic
radiosurgery for neovascular age-related macular degeneration. Phys Med Biol 57:6371–6380
28. Chattopadhyay N, Cai Z, Kwon YL, Lechtman E, Pignol JP, Reilly RM (2013) Molecularly
targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor
xenografts to X-radiation. Breast Cancer Res Treat 137:81–91
29. Hossain M, Su M (2012) Nanoparticle location and material dependent dose enhancement in
X-ray radiation therapy. J Phys Chem C Nanomater Interfaces 116:23047–23052
30. Cho SH (2005) Estimation of tumour dose enhancement due to gold nanoparticles during
typical radiation treatments: a preliminary Monte Carlo study. Phys Med Biol 50:N163–N173
31. Geng F, Song K, Xing JZ, Yuan C, Yan S, Yang Q, Chen J, Kong B (2011) Thio-glucose bound
gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer. Nanotechnology
22:285101
32. Allemann E, Brasseur N, Benrezzak O, Rousseau J, Kudrevich SV, Boyle RW, Leroux JC,
Gurny R, van Lier JE (1995) PEG-coated poly(lactic acid) nanoparticles for the delivery of
hexadecafluoro zinc phthalocyanine to EMT-6 mouse mammary tumours. J Pharm Pharmacol
47:382–387
33. Khlebtsov B, Panfilova E, Khanadeev V, Bibikova O, Terentyuk G, Ivanov A, Rumyantseva V,
Shilov I, Ryabova A, Loshchenov V, Khlebtsov NG (2011) Nanocomposites containing silicacoated gold-silver nanocages and Yb-2,4-dimethoxyhematoporphyrin: multifunctional capability of IR-luminescence detection, photosensitization, and photothermolysis. ACS Nano
5:7077–7089
34. Wason MS, Colon J, Das S, Seal S, Turkson J, Zhao J, Baker CH (2013) Sensitization of
pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production.
Nanomedicine 9:558–569
35. Timerbaev A, Sturup S (2012) Analytical approaches for assaying metallodrugs in biological
samples: recent methodological developments and future trends. Curr Drug Metab 13:272–283
36. Geraki K, Farquharson MJ, Bradley DA (2002) Concentrations of Fe, Cu and Zn in breast
tissue: a synchrotron XRF study. Phys Med Biol 47:2327
37. Costello LC, Franklin RB (1998) Novel role of zinc in the regulation of prostate citrate
metabolism and its implications in prostate cancer. Prostate 35:285–296
38. Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS,
Fineberg S, Pestell RG, Carrasco N (2000) The mammary gland iodide transporter is expressed
during lactation and in breast cancer. Nat Med 6:871–878
39. Naczynski DJ, Sun C, Turkcan S, Jenkins C, Koh AL, Ikeda D, Pratx G, Xing L (2015) X-rayinduced shortwave infrared biomedical imaging using rare-earth nanoprobes. Nano Lett
15:96–102
40. Chen D, Zhu S, Yi H, Zhang X, Chen D, Liang J, Tian J (2013) Cone beam x-ray luminescence
computed tomography: a feasibility study. Med Phys 40:031111
41. Yi Z, Lu W, Xu Y, Yang J, Deng L, Qian C, Zeng T, Wang H, Rao L, Liu H, Zeng S (2014)
PEGylated NaLuF4: Yb/Er upconversion nanophosphors for in vivo synergistic fluorescence/
X-ray bioimaging and long-lasting, real-time tracking. Biomaterials 35:9689–9697
42. Cong W, Wang C, Wang G (2014) Stored luminescence computed tomography. Appl Optics
53:5672–5676
43. Carpenter CM, Sun C, Pratx G, Rao R, Xing L (2010) Hybrid x-ray/optical luminescence
imaging: characterization of experimental conditions. Med Phys 37:4011–4018
44. Pratx G, Carpenter CM, Sun C, Rao RP, Xing L (2010) Tomographic molecular imaging of xray-excitable nanoparticles. Opt Lett 35:3345–3347
45. Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, Jerin J, Young J, Byars L,
Nutt R (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41:1369–1379
46. Schillaci O (2005) Hybrid SPECT/CT: a new era for SPECT imaging? Eur J Nucl Med Mol
Imaging 32:521–524
X-Ray Excited Fluorescent Materials for Medical Application
147