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2.3.5.1 CANARY Bioelectronic Sensor
The CANARY technology is based on genetically engineered white blood B cells,
which can bind to and to recognize pathogens quickly and assists other parts of the
immune system in fighting the infection. It is well known that B cells are the fastest
known pathogen identifiers (intrinsic response less than 1 s). The B-lymphocytes
recombinantly express cytosolic aequorin, a Ca-sensitive bioluminescent protein
from the jellyfish Aequoria victoria, which emits light in response to elevations of
intracellular Ca, along with the antibodies bound to the membrane. Binding of the
Fig. 2.12 Single QD-Based DNA nanosensor. (Adapted from Ref. [53])
J. H. Banoub and A. Mikhael
2.3.5.1 CANARY Bioelectronic Sensor
The CANARY technology is based on genetically engineered white blood B cells,
which can bind to and to recognize pathogens quickly and assists other parts of the
immune system in fighting the infection. It is well known that B cells are the fastest
known pathogen identifiers (intrinsic response less than 1 s). The B-lymphocytes
recombinantly express cytosolic aequorin, a Ca-sensitive bioluminescent protein
from the jellyfish Aequoria victoria, which emits light in response to elevations of
intracellular Ca, along with the antibodies bound to the membrane. Binding of the
Fig. 2.12 Single QD-Based DNA nanosensor. (Adapted from Ref. [53])
J. H. Banoub and A. Mikhael