255
© Springer Nature B.V. 2020
G. Sindona et al. (eds.), Toxic Chemical and Biological Agents, NATO Science
for Peace and Security Series A: Chemistry and Biology,
https://doi.org/10.1007/978-94-024-2041-8_25
Chapter 25
Luminescent Polymeric Nanovectors
Loaded with Darunavir for Treatment
of HIV-Associated Neurological Diseases
F. Rizzi, T. Latronico, A. Panniello, V. Laquintana, N. Denora, I. Arduino,
A. Fasano, C. M. Mastroianni, E. Fanizza, M. Striccoli, A. Agostiano,
G. M. Liuzzi, M. L. Curri, and N. Depalo
Human Immunodeficiency Virus (HIV)-associated neurocognitive disorders
(HAND) are worrying comorbidities of various severity in HIV-infected patients
over long term, arising from the invasion of HIV into the central nervous system
(CNS). Currently, antiretroviral therapy (ART) represents the more effective therapeutic approach to HAND. Darunavir (DRV) is an antiretroviral drug of the class of
HIV protease inhibitors and it has been approved for treatment of HIV-infected
patients in combination with other antiretroviral drugs. MMP-2 and MMP-9 are two
members of the family of matrix metalloproteinases (MMPs), that represent factors
responsible for the development of HIV-related neurological disorders. The ability
F. Rizzi (*) · A. Panniello · M. Striccoli · N. Depalo
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
e-mail: f.rizzi@ba.ipcf.cnr.it
T. Latronico · I. Arduino · A. Fasano · G. M. Liuzzi
Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari
Aldo Moro, Bari, Italy
V. Laquintana
Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro,
Bari, Italy
N. Denora
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco,
Bari, Italy
C. M. Mastroianni
Dipartimento di Sanità Pubblica e Malattie Infettive, Università degli Studi di Roma
“Sapienza”, Rome, Italy
E. Fanizza · A. Agostiano · M. L. Curri
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Dipartimento di Chimica, Università degli studi di Bari ‘Aldo Moro’, Bari, Italy
© Springer Nature B.V. 2020
G. Sindona et al. (eds.), Toxic Chemical and Biological Agents, NATO Science
for Peace and Security Series A: Chemistry and Biology,
https://doi.org/10.1007/978-94-024-2041-8_25
Chapter 25
Luminescent Polymeric Nanovectors
Loaded with Darunavir for Treatment
of HIV-Associated Neurological Diseases
F. Rizzi, T. Latronico, A. Panniello, V. Laquintana, N. Denora, I. Arduino,
A. Fasano, C. M. Mastroianni, E. Fanizza, M. Striccoli, A. Agostiano,
G. M. Liuzzi, M. L. Curri, and N. Depalo
Human Immunodeficiency Virus (HIV)-associated neurocognitive disorders
(HAND) are worrying comorbidities of various severity in HIV-infected patients
over long term, arising from the invasion of HIV into the central nervous system
(CNS). Currently, antiretroviral therapy (ART) represents the more effective therapeutic approach to HAND. Darunavir (DRV) is an antiretroviral drug of the class of
HIV protease inhibitors and it has been approved for treatment of HIV-infected
patients in combination with other antiretroviral drugs. MMP-2 and MMP-9 are two
members of the family of matrix metalloproteinases (MMPs), that represent factors
responsible for the development of HIV-related neurological disorders. The ability
F. Rizzi (*) · A. Panniello · M. Striccoli · N. Depalo
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
e-mail: f.rizzi@ba.ipcf.cnr.it
T. Latronico · I. Arduino · A. Fasano · G. M. Liuzzi
Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari
Aldo Moro, Bari, Italy
V. Laquintana
Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro,
Bari, Italy
N. Denora
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco,
Bari, Italy
C. M. Mastroianni
Dipartimento di Sanità Pubblica e Malattie Infettive, Università degli Studi di Roma
“Sapienza”, Rome, Italy
E. Fanizza · A. Agostiano · M. L. Curri
Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy
Dipartimento di Chimica, Università degli studi di Bari ‘Aldo Moro’, Bari, Italy