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Table 7.1 MALDI matrices and analyte applications
Matrix
Other
names
Chemical
structure
Application
(E)-4-(2,5-dihydroxyphenyl)but-3-en-2-one 2,5cDHA
Lipids
Peptides
Proteins
Positive and negative
ionization modes
2,5-dihydroxyacetophenone
2,5DHA
Lipids
Peptides
Proteins
Positive and negative
ionization modes
9-Aminoacridine
9-AA
Low molecular weight
metabolites
Lipids
Negative ionization
mode
α-Cyano-4-hydroxycinnamic acid
CHCA
Peptides
Proteins
Positive ionization
mode
5-Chloro-2-mercaptobenzothiazole
CMBT
Lipids
Peptides
Positive and negative
ionization modes
1–5,Diaminonapthalene
DAN
Lipids
Positive and negative
ionization modes
trans − 2-[3-(4-tert -Butylphenyl)-2methyl-2- propenylidene]malononitrile
DCTB
Carbohydrates
Polymers
Inorganic materials
Organometallics
Positive and negative
ionization modes
2,5-Dihydroxybenzoic acid
DHB
Low molecular weight
metabolites
Pharmacuticals
Lipids
Positive ionization
mode
3,5-Dimethoxy-4-hydroxycinnamic acid
Sinapic
acid
Peptides
Proteins
Positive ionization
mode
(continued)
J. C. McMillen et al.