107
20. Vermeirssen ELM et al (2005) Characterization of environmental estrogens in river water
using a three pronged approach: active and passive water sampling and the analysis of accumulated estrogens in the bile of caged fish. Environ Sci Technol 39(21):8191–8198
21. Macikova P et al (2014) Endocrine disrupting compounds affecting corticosteroid Signaling
pathways in Czech and Swiss waters: potential impact on fish. Environ Sci Technol
48(21):12902–12911
22. Tousova Z et al (2017) European demonstration program on the effect-based and chemical
identification and monitoring of organic pollutants in European surface waters. Sci Total
Environ 601:1849–1868
23. Bernet D et al (2004) Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland. Dis Aquat Org
61(1–2):137–148
24. Liedtke A et al (2009) Unpublished results
25. Soto AM et al (1995) The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103(suppl 7):113–122
26. Liedtke A et al (2009) Internal exposure of whitefish (Coregonus lavaretus) to estrogens. Aquat
Toxicol 93(2):158–165
27. Schymanski EL et al (2014) Strategies to characterize polar organic contamination in wastewater: exploring the capability of high resolution mass spectrometry. Environ Sci Technol
48(3):1811–1818
28. Singer HP et al (2016) Rapid screening for exposure to “non-target” pharmaceuticals from
wastewater effluents by combining HRMS-based suspect screening and exposure modeling.
Environ Sci Technol 50(13):6698–6707
29. Groh KJ et al (2011) Global proteomics analysis of testis and ovary in adult zebrafish (Danio
rerio). Fish Physiol Biochem 37(3):619–647
30. Nesatyy VJ, Suter MJ-F (2008) Analysis of environmental stress response on the proteome
level. Mass Spectrom Rev 27(6):556–574
31. Kind T, Fiehn O (2007) Seven Golden rules for heuristic filtering of molecular formulas
obtained by accurate mass spectrometry. BMC Bioinf 8:105–105
32. Groh KJ et al (2015) Development and application of the adverse outcome pathway framework
for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology. Chemosphere 120:764–777
33. Eggen RIL, Suter MJ-F (2007) Analytical chemistry and ecotoxicology—tasks, needs and
trends. J Toxic Environ Health A 70(9):724–726
34. Groh KJ et al (2015) Development and application of the adverse outcome pathway framework
for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish.
Chemosphere 120:778–792
35. Groh KJ, Tollefsen KE (2015) The challenge: adverse outcome pathways in research and regulation—current status and future perspectives. Environ Toxicol Chem 34(9):1935–1937
36. Van den Brink PJ et al (2018) Toward sustainable environmental quality: priority research
questions for Europe. Environ Toxicol Chem 37(9):2281–2295
37. Ashauer R et al (2011) Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal
endpoints: a brief discussion of concepts. Environ Toxicol Chem 30(11):2519–2524
38. Groh KJ, Suter MJ-F (2014) Mass spectrometry in environmental toxicology. CHIMIA Int J
Chem 68(3):140–145
39. Kirla KT et al (2016) From the cover: zebrafish larvae are insensitive to stimulation by cocaine:
importance of exposure route and toxicokinetics. Toxicol Sci 154(1):183–193
40. Mottaz H et al (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in
LPS efflux in teleost fish. Environ Pollut 221:105–115
41. Madureira DJ et al (2014) Systems toxicology approach to understand the kinetics of Benzo(a)
pyrene uptake, biotransformation, and DNA adduct formation in a liver cell model. Chem Res
Toxicol 27(3):443–453
6 Mass Spectrometry in Ecotoxicology
20. Vermeirssen ELM et al (2005) Characterization of environmental estrogens in river water
using a three pronged approach: active and passive water sampling and the analysis of accumulated estrogens in the bile of caged fish. Environ Sci Technol 39(21):8191–8198
21. Macikova P et al (2014) Endocrine disrupting compounds affecting corticosteroid Signaling
pathways in Czech and Swiss waters: potential impact on fish. Environ Sci Technol
48(21):12902–12911
22. Tousova Z et al (2017) European demonstration program on the effect-based and chemical
identification and monitoring of organic pollutants in European surface waters. Sci Total
Environ 601:1849–1868
23. Bernet D et al (2004) Frequent and unexplained gonadal abnormalities in whitefish (central alpine Coregonus sp.) from an alpine oligotrophic lake in Switzerland. Dis Aquat Org
61(1–2):137–148
24. Liedtke A et al (2009) Unpublished results
25. Soto AM et al (1995) The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103(suppl 7):113–122
26. Liedtke A et al (2009) Internal exposure of whitefish (Coregonus lavaretus) to estrogens. Aquat
Toxicol 93(2):158–165
27. Schymanski EL et al (2014) Strategies to characterize polar organic contamination in wastewater: exploring the capability of high resolution mass spectrometry. Environ Sci Technol
48(3):1811–1818
28. Singer HP et al (2016) Rapid screening for exposure to “non-target” pharmaceuticals from
wastewater effluents by combining HRMS-based suspect screening and exposure modeling.
Environ Sci Technol 50(13):6698–6707
29. Groh KJ et al (2011) Global proteomics analysis of testis and ovary in adult zebrafish (Danio
rerio). Fish Physiol Biochem 37(3):619–647
30. Nesatyy VJ, Suter MJ-F (2008) Analysis of environmental stress response on the proteome
level. Mass Spectrom Rev 27(6):556–574
31. Kind T, Fiehn O (2007) Seven Golden rules for heuristic filtering of molecular formulas
obtained by accurate mass spectrometry. BMC Bioinf 8:105–105
32. Groh KJ et al (2015) Development and application of the adverse outcome pathway framework
for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology. Chemosphere 120:764–777
33. Eggen RIL, Suter MJ-F (2007) Analytical chemistry and ecotoxicology—tasks, needs and
trends. J Toxic Environ Health A 70(9):724–726
34. Groh KJ et al (2015) Development and application of the adverse outcome pathway framework
for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish.
Chemosphere 120:778–792
35. Groh KJ, Tollefsen KE (2015) The challenge: adverse outcome pathways in research and regulation—current status and future perspectives. Environ Toxicol Chem 34(9):1935–1937
36. Van den Brink PJ et al (2018) Toward sustainable environmental quality: priority research
questions for Europe. Environ Toxicol Chem 37(9):2281–2295
37. Ashauer R et al (2011) Toxicokinetic-toxicodynamic modeling of quantal and graded sublethal
endpoints: a brief discussion of concepts. Environ Toxicol Chem 30(11):2519–2524
38. Groh KJ, Suter MJ-F (2014) Mass spectrometry in environmental toxicology. CHIMIA Int J
Chem 68(3):140–145
39. Kirla KT et al (2016) From the cover: zebrafish larvae are insensitive to stimulation by cocaine:
importance of exposure route and toxicokinetics. Toxicol Sci 154(1):183–193
40. Mottaz H et al (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in
LPS efflux in teleost fish. Environ Pollut 221:105–115
41. Madureira DJ et al (2014) Systems toxicology approach to understand the kinetics of Benzo(a)
pyrene uptake, biotransformation, and DNA adduct formation in a liver cell model. Chem Res
Toxicol 27(3):443–453
6 Mass Spectrometry in Ecotoxicology