6. Boxall ABA, Johnson P, Smith EJ, Sinclair CJ, Stutt E, Levy LS (2006) Uptake of veterinary
medicines from soils into plants. J Agric Food Chem 54:2288–2297
7. De Meyer G, Capieau K, Audenaert K, Buchala A, Métraux JP, Höfte M (1999) Nanogram
Amounts of salicylic acid produced by the Rhizobacterium Pseudomonas aeruginosa 7NSK2
activate the systemic acquired resistance pathway in bean. Mol Plant-Microbe Interact
12:450–458
8. Manthe B, Schulz M, Schnabl H (1992) Effects of salicylic acid on growth and stomatal
movements of Vicia faba L.: Evidence for salicylic acid metabolization. J Chem Ecol
18:1525–1539
9. Forde BG (2000) Review: nitrate transporters in plants: structure, function and regulation.
Biochim Biophys Acta 1465:219–235
10. Buchner P, Takahashi H, Hawkesford MJ (2004) Plant sulphate transporters: co-ordination of
uptake, intracellular and long-distance transport. J Exp Bot 55 (Special Issue: Sulphur Metabolism in Plants): 1765–1773
11. Kobayashi T, Nishizawa NK (2012) Iron uptake, translocation, and regulation in higher plants.
Annu Rev Plant Biol 63:131–152
12. Inoue J, Chamberlain K, Bromilow RH (1998) Physicochemical factors affecting the uptake
by roots and translocation to shoots of amine bases in barley. Pest Manag Sci 54:8–21
13. Nwoko CO (2010) Trends in phytoremediation of toxic elemental and organic pollutants. Afr J
Biotechnol 9:6010–6016
14. Sibout R, Höfte H (2012) Plant cell biology: the ABC of monolignol transport. Curr Biol 22:
R533–R535
15. European Commission Decision (2009) Concerning the non-inclusion of nicotine in Annex I to
Council Directive 91/414/EEC and the withdrawal of authorisations for plant protection
products containing that substance. Official Journal of the European Union L 5/9–09 01 2009
16. EFSA Panel on Contaminants in the Food Chain (2011) Scientific opinion on pyrrolizidine
alkaloids in food and feed. EFSA J 9(11):2406
17. Mulder PPJ, Sánchez PL, These A, Preiss-Weigert A, Castellari M (2015) Occurrence of
Pyrrolizidine alkaloids in food. EFSA supporting publication: EN-859. EFSA J. 12(8).
18. Selmar D, Engelhardt UH, Hänsel S, Thräne C, Nowak M, Kleinwächter M (2015) Nicotine
uptake by peppermint plants as a possible source of nicotine in plant-derived products. Agron
Sustain Dev 35:1185–1190
19. Selmar D, Radwan A, Abdalla N, Taha H, Wittke C, El-Henawy A, Alshaal T, Amer M, Nowak
M, El-Ramady H (2018) Uptake of nicotine from discarded cigarette butts – a so far unconsidered path of contamination of plant derived commodities. Environ Pollut 238:972–976
20. Nowak M, Wittke C, Lederer I, Klier B, Kleinwächter M, Selmar D (2016) Interspecific transfer
of pyrrolizidine alkaloids: An unconsidered source of contaminations of phytopharmaceuticals
and plant derived commodities. Food Chem 213:163–168
21. Selmar D, Radwan A, Nowak M (2015) Horizontal natural product transfer: a so far unconsidered source of contamination of plant-derived commodities. J Environ Anal Toxicol 5:4
22. Yazaki K (2006) ABC transporters involved in the transport of plant secondary metabolites.
FEBS Lett 580:1183–1191
23. Rea PA (2007) Plant ATP-binding cassette transporters. Annu Rev Plant Biol 58:347–375
24. Remy E, Duque P (2014) Beyond cellular detoxification: a plethora of physiological roles for
MDR transporter homologs in plants. Front Physiol 5:S. 201
25. Trapp S (2000) Modelling uptake into roots and subsequent translocation of neutral and
ionisable organic compounds. Pest Manag Sci 56:767–778
26. Trapp S (2009) Bioaccumulation of polar and ionizable compounds in plants. In: Devillers J
(ed) Ecotoxicology modeling. Springer, New York
27. Cronin MTD, Livingstone J (2004) Calculation of physiochemical properties. In: Cronin TD,
Livingstone J (eds) Predicting chemical toxicity and fate. CRC Press, Boca Raton
28. Limmer MA, Burken JG (2014) Plant translocation of organic compounds. Molecular and
physicochemical predictors. Environ Sci Technol Lett 1:156–161
438
D. Selmar et al.
medicines from soils into plants. J Agric Food Chem 54:2288–2297
7. De Meyer G, Capieau K, Audenaert K, Buchala A, Métraux JP, Höfte M (1999) Nanogram
Amounts of salicylic acid produced by the Rhizobacterium Pseudomonas aeruginosa 7NSK2
activate the systemic acquired resistance pathway in bean. Mol Plant-Microbe Interact
12:450–458
8. Manthe B, Schulz M, Schnabl H (1992) Effects of salicylic acid on growth and stomatal
movements of Vicia faba L.: Evidence for salicylic acid metabolization. J Chem Ecol
18:1525–1539
9. Forde BG (2000) Review: nitrate transporters in plants: structure, function and regulation.
Biochim Biophys Acta 1465:219–235
10. Buchner P, Takahashi H, Hawkesford MJ (2004) Plant sulphate transporters: co-ordination of
uptake, intracellular and long-distance transport. J Exp Bot 55 (Special Issue: Sulphur Metabolism in Plants): 1765–1773
11. Kobayashi T, Nishizawa NK (2012) Iron uptake, translocation, and regulation in higher plants.
Annu Rev Plant Biol 63:131–152
12. Inoue J, Chamberlain K, Bromilow RH (1998) Physicochemical factors affecting the uptake
by roots and translocation to shoots of amine bases in barley. Pest Manag Sci 54:8–21
13. Nwoko CO (2010) Trends in phytoremediation of toxic elemental and organic pollutants. Afr J
Biotechnol 9:6010–6016
14. Sibout R, Höfte H (2012) Plant cell biology: the ABC of monolignol transport. Curr Biol 22:
R533–R535
15. European Commission Decision (2009) Concerning the non-inclusion of nicotine in Annex I to
Council Directive 91/414/EEC and the withdrawal of authorisations for plant protection
products containing that substance. Official Journal of the European Union L 5/9–09 01 2009
16. EFSA Panel on Contaminants in the Food Chain (2011) Scientific opinion on pyrrolizidine
alkaloids in food and feed. EFSA J 9(11):2406
17. Mulder PPJ, Sánchez PL, These A, Preiss-Weigert A, Castellari M (2015) Occurrence of
Pyrrolizidine alkaloids in food. EFSA supporting publication: EN-859. EFSA J. 12(8).
18. Selmar D, Engelhardt UH, Hänsel S, Thräne C, Nowak M, Kleinwächter M (2015) Nicotine
uptake by peppermint plants as a possible source of nicotine in plant-derived products. Agron
Sustain Dev 35:1185–1190
19. Selmar D, Radwan A, Abdalla N, Taha H, Wittke C, El-Henawy A, Alshaal T, Amer M, Nowak
M, El-Ramady H (2018) Uptake of nicotine from discarded cigarette butts – a so far unconsidered path of contamination of plant derived commodities. Environ Pollut 238:972–976
20. Nowak M, Wittke C, Lederer I, Klier B, Kleinwächter M, Selmar D (2016) Interspecific transfer
of pyrrolizidine alkaloids: An unconsidered source of contaminations of phytopharmaceuticals
and plant derived commodities. Food Chem 213:163–168
21. Selmar D, Radwan A, Nowak M (2015) Horizontal natural product transfer: a so far unconsidered source of contamination of plant-derived commodities. J Environ Anal Toxicol 5:4
22. Yazaki K (2006) ABC transporters involved in the transport of plant secondary metabolites.
FEBS Lett 580:1183–1191
23. Rea PA (2007) Plant ATP-binding cassette transporters. Annu Rev Plant Biol 58:347–375
24. Remy E, Duque P (2014) Beyond cellular detoxification: a plethora of physiological roles for
MDR transporter homologs in plants. Front Physiol 5:S. 201
25. Trapp S (2000) Modelling uptake into roots and subsequent translocation of neutral and
ionisable organic compounds. Pest Manag Sci 56:767–778
26. Trapp S (2009) Bioaccumulation of polar and ionizable compounds in plants. In: Devillers J
(ed) Ecotoxicology modeling. Springer, New York
27. Cronin MTD, Livingstone J (2004) Calculation of physiochemical properties. In: Cronin TD,
Livingstone J (eds) Predicting chemical toxicity and fate. CRC Press, Boca Raton
28. Limmer MA, Burken JG (2014) Plant translocation of organic compounds. Molecular and
physicochemical predictors. Environ Sci Technol Lett 1:156–161
438
D. Selmar et al.