49. O’Donnell K, Sutton DA, Rinaldi MG et al (2010) An Internet-accessible DNA sequence
database for identifying fusaria from human and animal infections. J Clin Microbiol
48:3708–3718
50. O’Donnell K, Ward TJ, Robert VARG et al (2015) DNA sequence-based identification of
Fusarium: current status and future directions. Phytoparasitica 43:583–595
51. Waalwijk C, Taga M, Zheng S-L et al (2018) Karyotype evolution in Fusarium. Ima Fungus
9:13–26
52. O’Donnell K, Rooney AP, Proctor RH et al (2013) Phylogenetic analyses of RPB1 and RPB2
support a middle Cretaceous origin for a clade comprising all agriculturally and medically
important fusaria. Fungal Genet Biol 52:20–31
53. Laurence MH, Summerell BA, Burgess LW, Liew ECY (2011) Fusarium burgessii sp.nov.
representing a novel lineage in the genus Fusarium. Fungal Divers 49:101–112
54. Zhou X, O’Donnell K, Aoki T et al (2016) Two novel Fusarium species that cause canker
disease of prickly ash (Zanthoxylum bungeanum) in northern China form a novel clade with
Fusarium torreyae. Mycologia 108:668–681
55. Hansen FT, Gardiner DM, Lysøe E et al (2015) An update to polyketide synthase and
non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genet Biol
75:20–29
56. Brown DW, Proctor RH (2016) Insights into natural products biosynthesis from analysis of
490 polyketide synthases from Fusarium. Fungal Genet Biol 89:37–51
57. Kim H-S, Proctor RH, Brown DW (2017) Comparative genomic analyses of secondary
metabolite biosynthetic gene clusters in 207 isolates of Fusarium. In: 29th fungal genetics
conference. Genetics Society of America, Pacific Grove
58. Pestka JJ (2010) Deoxynivalenol: mechanisms of action, human exposure, and toxicological
relevance. Arch Toxicol 84:663–679
59. Susca A, Moretti A, Logrieco AF (2017) Mycotoxin biosynthetic pathways: a window on the
evolutionary relationships among toxigenic fungi. In: Varma A, Sharma A (eds) Modern tools
and techniques to understand microbes. Springer, Cham
60. Bertero A, Spicer LJ, Caloni F (2018) Fusarium mycotoxins and in vitro species-specific
approach with porcine intestinal and brain in vitro barriers: a review. Food Chem Toxicol
121:666–675
61. Proctor RH, Hohn TM, McCormick SP (1995) Reduced virulence of Gibberella zeae caused
by disruption of a trichothecene toxin biosynthetic gene. Mol Plant-Microbe Interact
8:593–601
62. Wiemann P, Sieber CMK, von Bargen KW et al (2013) Deciphering the cryptic genome:
genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of
secondary metabolism and novel metabolites. PLoS Pathog 9:e1003475
63. Niehaus EM, Munsterkotter M, Proctor RH et al (2016) Comparative “omics” of the Fusarium
fujikuroi species complex highlights differences in genetic potential and metabolite synthesis.
Genome Biol Evol 8:3574–3599
64. Ma L-J, Geiser DM, Proctor RH et al (2013) Fusarium pathogenomics. Annu Rev Microbiol
67:399–416
65. Zhang Y, Ma L-J (2017) Deciphering pathogenicity of Fusarium oxysporum from
a phylogenomics perspective. Adv Genet 100:179–209
66. Ma L-J, van der Does HC, Borkovich KA et al (2010) Comparative genomics reveals mobile
pathogenicity chromosomes in Fusarium. Nature 464:367–373
67. Vesonder RF, Goliński P (1989) Metabolites of Fusarium. In: Chełkowski J (ed) Fusarium
mycotoxins: taxonomy and pathogenicity. Elsevier, Amsterdam
68. Cole RJ, Schweikert MA (2003) Handbook of secondary fungal metabolites, vol I. Academic,
San Diego
69. Hansen FT, Sørensen JL, Giese H et al (2012) Quick guide to polyketide synthase and
nonribosomal synthetase genes in Fusarium. Int J Food Microbiol 155:128–136
10 Fusarium Secondary Metabolism Biosynthetic Pathways: So Close but So. . .
239
database for identifying fusaria from human and animal infections. J Clin Microbiol
48:3708–3718
50. O’Donnell K, Ward TJ, Robert VARG et al (2015) DNA sequence-based identification of
Fusarium: current status and future directions. Phytoparasitica 43:583–595
51. Waalwijk C, Taga M, Zheng S-L et al (2018) Karyotype evolution in Fusarium. Ima Fungus
9:13–26
52. O’Donnell K, Rooney AP, Proctor RH et al (2013) Phylogenetic analyses of RPB1 and RPB2
support a middle Cretaceous origin for a clade comprising all agriculturally and medically
important fusaria. Fungal Genet Biol 52:20–31
53. Laurence MH, Summerell BA, Burgess LW, Liew ECY (2011) Fusarium burgessii sp.nov.
representing a novel lineage in the genus Fusarium. Fungal Divers 49:101–112
54. Zhou X, O’Donnell K, Aoki T et al (2016) Two novel Fusarium species that cause canker
disease of prickly ash (Zanthoxylum bungeanum) in northern China form a novel clade with
Fusarium torreyae. Mycologia 108:668–681
55. Hansen FT, Gardiner DM, Lysøe E et al (2015) An update to polyketide synthase and
non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genet Biol
75:20–29
56. Brown DW, Proctor RH (2016) Insights into natural products biosynthesis from analysis of
490 polyketide synthases from Fusarium. Fungal Genet Biol 89:37–51
57. Kim H-S, Proctor RH, Brown DW (2017) Comparative genomic analyses of secondary
metabolite biosynthetic gene clusters in 207 isolates of Fusarium. In: 29th fungal genetics
conference. Genetics Society of America, Pacific Grove
58. Pestka JJ (2010) Deoxynivalenol: mechanisms of action, human exposure, and toxicological
relevance. Arch Toxicol 84:663–679
59. Susca A, Moretti A, Logrieco AF (2017) Mycotoxin biosynthetic pathways: a window on the
evolutionary relationships among toxigenic fungi. In: Varma A, Sharma A (eds) Modern tools
and techniques to understand microbes. Springer, Cham
60. Bertero A, Spicer LJ, Caloni F (2018) Fusarium mycotoxins and in vitro species-specific
approach with porcine intestinal and brain in vitro barriers: a review. Food Chem Toxicol
121:666–675
61. Proctor RH, Hohn TM, McCormick SP (1995) Reduced virulence of Gibberella zeae caused
by disruption of a trichothecene toxin biosynthetic gene. Mol Plant-Microbe Interact
8:593–601
62. Wiemann P, Sieber CMK, von Bargen KW et al (2013) Deciphering the cryptic genome:
genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of
secondary metabolism and novel metabolites. PLoS Pathog 9:e1003475
63. Niehaus EM, Munsterkotter M, Proctor RH et al (2016) Comparative “omics” of the Fusarium
fujikuroi species complex highlights differences in genetic potential and metabolite synthesis.
Genome Biol Evol 8:3574–3599
64. Ma L-J, Geiser DM, Proctor RH et al (2013) Fusarium pathogenomics. Annu Rev Microbiol
67:399–416
65. Zhang Y, Ma L-J (2017) Deciphering pathogenicity of Fusarium oxysporum from
a phylogenomics perspective. Adv Genet 100:179–209
66. Ma L-J, van der Does HC, Borkovich KA et al (2010) Comparative genomics reveals mobile
pathogenicity chromosomes in Fusarium. Nature 464:367–373
67. Vesonder RF, Goliński P (1989) Metabolites of Fusarium. In: Chełkowski J (ed) Fusarium
mycotoxins: taxonomy and pathogenicity. Elsevier, Amsterdam
68. Cole RJ, Schweikert MA (2003) Handbook of secondary fungal metabolites, vol I. Academic,
San Diego
69. Hansen FT, Sørensen JL, Giese H et al (2012) Quick guide to polyketide synthase and
nonribosomal synthetase genes in Fusarium. Int J Food Microbiol 155:128–136
10 Fusarium Secondary Metabolism Biosynthetic Pathways: So Close but So. . .
239