56. Salehi B, Venditti A, Sharifi-Rad M, Kręgiel D, Sharifi-Rad J, Durazzo A, Lucarini M, Santini
A, Souto E, Novellino E, Antolak H, Azzini E, Setzer W, Martins N (2019) The therapeutic
potential of apigenin. Int J Mol Sci 20:1305. https://doi.org/10.3390/ijms20061305
57. Ali F, Rahul NF, Jyoti S, Siddique YH (2017) Health functionality of apigenin: a review. Int J
Food Prop 20:1197–1238. https://doi.org/10.1080/10942912.2016.1207188
58. Cirmi S, Ferlazzo N, Lombardo G, Ventura-Spagnolo E, Gangemi S, Calapai G, Navarra M
(2016) Neurodegenerative diseases: might citrus flavonoids play a protective role? Molecules
21:1312. https://doi.org/10.3390/molecules21101312
59. Kavutcu M, Melzig MF (1999) In vitro effects of selected flavonoids on the 5
0 -nucleotidase
activity. Pharmazie 54:457–459
60. Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M (2004)
Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid
compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. https://doi.org/
10.1093/toxsci/kfh257
61. Lindahl M, Tagesson C (1997) Flavonoids as phospholipase A2 inhibitors: importance of their
structure for selective inhibition of group II phospholipase A2. Inflammation 21:347–356.
https://doi.org/10.1023/A:1027306118026
62. Lamy S, Bedard V, Labbe D, Sartelet H, Barthomeuf C, Gingras D, Beliveau R (2008) The
dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-phosphorylation. Cancer Prev Res 1:452–459. https://doi.
org/10.1158/1940-6207.CAPR-08-0072
63. Guerrero L, Castillo J, Quiñones M, Garcia-Vallvé S, Arola L, Pujadas G, Muguerza B (2012)
Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. PLoS One 7:e49493. https://doi.org/10.1371/journal.pone.0049493
64. Si D, Wang Y, Zhou YH, Guo Y, Wang J, Zhou H, Li ZS, Fawcett JP (2009) Mechanism of
CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos 37:629–634. https://doi.org/
10.1124/dmd.108.023416
65. Mierziak J, Kostyn K, Kulma A (2014) Flavonoids as important molecules of plant
interactions with the environment. Molecules 19:16240–16265. https://doi.org/10.3390/
molecules191016240
6 Molecular Interactions as Drivers of Changes in Marine Ecosystems
133
A, Souto E, Novellino E, Antolak H, Azzini E, Setzer W, Martins N (2019) The therapeutic
potential of apigenin. Int J Mol Sci 20:1305. https://doi.org/10.3390/ijms20061305
57. Ali F, Rahul NF, Jyoti S, Siddique YH (2017) Health functionality of apigenin: a review. Int J
Food Prop 20:1197–1238. https://doi.org/10.1080/10942912.2016.1207188
58. Cirmi S, Ferlazzo N, Lombardo G, Ventura-Spagnolo E, Gangemi S, Calapai G, Navarra M
(2016) Neurodegenerative diseases: might citrus flavonoids play a protective role? Molecules
21:1312. https://doi.org/10.3390/molecules21101312
59. Kavutcu M, Melzig MF (1999) In vitro effects of selected flavonoids on the 5
0 -nucleotidase
activity. Pharmazie 54:457–459
60. Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M (2004)
Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid
compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. https://doi.org/
10.1093/toxsci/kfh257
61. Lindahl M, Tagesson C (1997) Flavonoids as phospholipase A2 inhibitors: importance of their
structure for selective inhibition of group II phospholipase A2. Inflammation 21:347–356.
https://doi.org/10.1023/A:1027306118026
62. Lamy S, Bedard V, Labbe D, Sartelet H, Barthomeuf C, Gingras D, Beliveau R (2008) The
dietary flavones apigenin and luteolin impair smooth muscle cell migration and VEGF expression through inhibition of PDGFR-phosphorylation. Cancer Prev Res 1:452–459. https://doi.
org/10.1158/1940-6207.CAPR-08-0072
63. Guerrero L, Castillo J, Quiñones M, Garcia-Vallvé S, Arola L, Pujadas G, Muguerza B (2012)
Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. PLoS One 7:e49493. https://doi.org/10.1371/journal.pone.0049493
64. Si D, Wang Y, Zhou YH, Guo Y, Wang J, Zhou H, Li ZS, Fawcett JP (2009) Mechanism of
CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos 37:629–634. https://doi.org/
10.1124/dmd.108.023416
65. Mierziak J, Kostyn K, Kulma A (2014) Flavonoids as important molecules of plant
interactions with the environment. Molecules 19:16240–16265. https://doi.org/10.3390/
molecules191016240
6 Molecular Interactions as Drivers of Changes in Marine Ecosystems
133