41. Guidetti P (2006) Marine reserves reestablish lost predatory interactions. Ecol Appl
16:963–976. https://doi.org/10.1890/1051-0761(2006)016[0963:MRRLPI]2.0.CO;2
42. Sala E, Zabala M (1996) Fish predation and the structure of the sea urchin Paracentrotus lividus
populations in the NW Mediterranean. Mar Ecol Prog Ser 140:71–81. https://doi.org/10.3354/
meps140071
43. Terlizzi A, Felline S, Lionetto MG, Caricato R, Perfetti V, Cutignano A, Mollo E (2011)
Detrimental physiological effects of the invasive alga Caulerpa racemosa on the Mediterranean
white seabream Diplodus sargus. Aquat Biol 12:109–117. https://doi.org/10.3354/ab00330
44. Felline S, Caricato R, Cutignano A, Gorbi S, Lionetto MG, Mollo E, Regoli F, Terlizzi A (2012)
Subtle effects of biological invasions: cellular and physiological responses of fish eating the
exotic pest Caulerpa racemosa. PLoS One 7:e38763. https://doi.org/10.1371/journal.
pone.0038763
45. Gorbi S, Giuliani ME, Pittura L, D’Errico G, Terlizzi A, Felline S, Grauso L, Mollo E,
Cutignano A, Regoli F (2014) Could molecular effects of Caulerpa racemosa metabolites
modulate the impact on fish populations of Diplodus sargus? Mar Environ Res 96:2–11. https://
doi.org/10.1016/j.marenvres.2014.01.010
46. Felline S, Mollo E, Ferramosca A, Zara V, Regoli F, Gorbi S, Terlizzi A (2014) Can a marine
pest reduce the nutritional value of Mediterranean fish flesh? Mar Biol 161:1275–1283. https://
doi.org/10.1007/s00227-014-2417-7
47. Del Coco L, Felline S, Girelli C, Angilè F, Magliozzi L, Almada F, D’Aniello B, Mollo E,
Terlizzi A, Fanizzi F (2018) 1H NMR spectroscopy and MVA to evaluate the effects of
caulerpin-based diet on Diplodus sargus lipid profiles. Mar Drugs 16:390. https://doi.org/
10.3390/md16100390
48. Felline S, Mollo E, Cutignano A, Grauso L, Andaloro F, Castriota L, Consoli P, Falautano M,
Sinopoli M, Terlizzi A (2017) Preliminary observations of caulerpin accumulation from the
invasive Caulerpa cylindracea in native Mediterranean fish species. Aquat Biol 26:27–31.
https://doi.org/10.3354/ab00671
49. Magliozzi L, Almada F, Robalo J, Mollo E, Polese G, Gonçalves EJ, Felline S, Terlizzi A,
D’Aniello B (2017) Cryptic effects of biological invasions: reduction of the aggressive behaviour of a native fish under the influence of an “invasive” biomolecule. PLoS One 12:e0185620.
https://doi.org/10.1371/journal.pone.0185620
50. Magliozzi L, Maselli V, Almada F, Di Cosmo A, Mollo E, Polese G (2019) Effect of the algal
alkaloid caulerpin on neuropeptide Y (NPY) expression in the central nervous system (CNS) of
Diplodus sargus. J Comp Physiol A 205:203–210. https://doi.org/10.1007/s00359-019-01322-8
51. Vitale R, D’Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani M, Fellous T, Gentile A,
Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D’Aniello B, Defranoux F, Felline
S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E (2018) Fishing for targets
of alien metabolites: a novel peroxisome proliferator-activated receptor (PPAR) agonist from a
marine pest. Mar Drugs 16:431. https://doi.org/10.3390/md16110431
52. Gavagnin M, Carbone M, Nappo M, Mollo E, Roussis V, Cimino G (2005) First chemical study
of anaspidean Syphonota geographica: structure of degraded sterols aplykurodinone-1 and -2.
Tetrahedron 61:617–621. https://doi.org/10.1016/j.tet.2004.10.093
53. Carbone M, Gavagnin M, Mollo E, Bidello M, Roussis V, Cimino G (2008) Further
syphonosides from the sea hare Syphonota geographica and the sea-grass Halophila stipulacea.
Tetrahedron 64:191–196. https://doi.org/10.1016/j.tet.2007.10.071
54. Bitam F, Ciavatta ML, Carbone M, Manzo E, Mollo E, Gavagnin M (2010) Chemical analysis
of flavonoid constituents of the seagrass Halophila stipulacea: first finding of malonylated
derivatives in marine phanerogams. Biochem Syst Ecol 38:686–690. https://doi.org/10.1016/j.
bse.2010.04.007
55. Zidorn C (2016) Secondary metabolites of seagrasses (Alismatales and Potamogetonales;
Alismatidae): chemical diversity, bioactivity, and ecological function. Phytochemistry
124:5–28. https://doi.org/10.1016/j.phytochem.2016.02.004
132
F. Defranoux and E. Mollo
16:963–976. https://doi.org/10.1890/1051-0761(2006)016[0963:MRRLPI]2.0.CO;2
42. Sala E, Zabala M (1996) Fish predation and the structure of the sea urchin Paracentrotus lividus
populations in the NW Mediterranean. Mar Ecol Prog Ser 140:71–81. https://doi.org/10.3354/
meps140071
43. Terlizzi A, Felline S, Lionetto MG, Caricato R, Perfetti V, Cutignano A, Mollo E (2011)
Detrimental physiological effects of the invasive alga Caulerpa racemosa on the Mediterranean
white seabream Diplodus sargus. Aquat Biol 12:109–117. https://doi.org/10.3354/ab00330
44. Felline S, Caricato R, Cutignano A, Gorbi S, Lionetto MG, Mollo E, Regoli F, Terlizzi A (2012)
Subtle effects of biological invasions: cellular and physiological responses of fish eating the
exotic pest Caulerpa racemosa. PLoS One 7:e38763. https://doi.org/10.1371/journal.
pone.0038763
45. Gorbi S, Giuliani ME, Pittura L, D’Errico G, Terlizzi A, Felline S, Grauso L, Mollo E,
Cutignano A, Regoli F (2014) Could molecular effects of Caulerpa racemosa metabolites
modulate the impact on fish populations of Diplodus sargus? Mar Environ Res 96:2–11. https://
doi.org/10.1016/j.marenvres.2014.01.010
46. Felline S, Mollo E, Ferramosca A, Zara V, Regoli F, Gorbi S, Terlizzi A (2014) Can a marine
pest reduce the nutritional value of Mediterranean fish flesh? Mar Biol 161:1275–1283. https://
doi.org/10.1007/s00227-014-2417-7
47. Del Coco L, Felline S, Girelli C, Angilè F, Magliozzi L, Almada F, D’Aniello B, Mollo E,
Terlizzi A, Fanizzi F (2018) 1H NMR spectroscopy and MVA to evaluate the effects of
caulerpin-based diet on Diplodus sargus lipid profiles. Mar Drugs 16:390. https://doi.org/
10.3390/md16100390
48. Felline S, Mollo E, Cutignano A, Grauso L, Andaloro F, Castriota L, Consoli P, Falautano M,
Sinopoli M, Terlizzi A (2017) Preliminary observations of caulerpin accumulation from the
invasive Caulerpa cylindracea in native Mediterranean fish species. Aquat Biol 26:27–31.
https://doi.org/10.3354/ab00671
49. Magliozzi L, Almada F, Robalo J, Mollo E, Polese G, Gonçalves EJ, Felline S, Terlizzi A,
D’Aniello B (2017) Cryptic effects of biological invasions: reduction of the aggressive behaviour of a native fish under the influence of an “invasive” biomolecule. PLoS One 12:e0185620.
https://doi.org/10.1371/journal.pone.0185620
50. Magliozzi L, Maselli V, Almada F, Di Cosmo A, Mollo E, Polese G (2019) Effect of the algal
alkaloid caulerpin on neuropeptide Y (NPY) expression in the central nervous system (CNS) of
Diplodus sargus. J Comp Physiol A 205:203–210. https://doi.org/10.1007/s00359-019-01322-8
51. Vitale R, D’Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani M, Fellous T, Gentile A,
Carbone M, Cutignano A, Grauso L, Magliozzi L, Polese G, D’Aniello B, Defranoux F, Felline
S, Terlizzi A, Calignano A, Regoli F, Di Marzo V, Amodeo P, Mollo E (2018) Fishing for targets
of alien metabolites: a novel peroxisome proliferator-activated receptor (PPAR) agonist from a
marine pest. Mar Drugs 16:431. https://doi.org/10.3390/md16110431
52. Gavagnin M, Carbone M, Nappo M, Mollo E, Roussis V, Cimino G (2005) First chemical study
of anaspidean Syphonota geographica: structure of degraded sterols aplykurodinone-1 and -2.
Tetrahedron 61:617–621. https://doi.org/10.1016/j.tet.2004.10.093
53. Carbone M, Gavagnin M, Mollo E, Bidello M, Roussis V, Cimino G (2008) Further
syphonosides from the sea hare Syphonota geographica and the sea-grass Halophila stipulacea.
Tetrahedron 64:191–196. https://doi.org/10.1016/j.tet.2007.10.071
54. Bitam F, Ciavatta ML, Carbone M, Manzo E, Mollo E, Gavagnin M (2010) Chemical analysis
of flavonoid constituents of the seagrass Halophila stipulacea: first finding of malonylated
derivatives in marine phanerogams. Biochem Syst Ecol 38:686–690. https://doi.org/10.1016/j.
bse.2010.04.007
55. Zidorn C (2016) Secondary metabolites of seagrasses (Alismatales and Potamogetonales;
Alismatidae): chemical diversity, bioactivity, and ecological function. Phytochemistry
124:5–28. https://doi.org/10.1016/j.phytochem.2016.02.004
132
F. Defranoux and E. Mollo