4.5 Drugs for Veterinary Use Only
Benzimidazole anthelmintics are frequently employed in the treatment of animals
against their infestation with parasitic worms with the unwanted side effect that these
substances are released to the environment and subsequently can interact with the
agricultural system. Uptake and metabolization of anthelmintics have been investigated in Campanula rotundifolia [86] and Plantago lanceolata [61, 87] whereby
experiments with whole plants allowed to propose schemes for metabolization of
albendazole, fenbendazole, and flubendazole. As an example of the metabolic
pathway of drugs in plants, the transformation of albendazole in Plantago
Fig. 4 Schematics of identifying unknown metabolites of gemfibrozil in Arabidopsis cells using
stable isotope labeling coupled to high-resolution mass spectrometry. Main steps include (a) create
a mixture of labeled and unlabeled gemfibrozil, (b) expose the gemfibrozil mixture to Arabidopsis
cells, (c) identify metabolite candidates, and (d) elucidate structure of metabolites. Reprinted with
permission from [63]. Copyright (2018) American Chemical Society
Analytical Approaches for the Determination and Identification of Drug. . .
515
Benzimidazole anthelmintics are frequently employed in the treatment of animals
against their infestation with parasitic worms with the unwanted side effect that these
substances are released to the environment and subsequently can interact with the
agricultural system. Uptake and metabolization of anthelmintics have been investigated in Campanula rotundifolia [86] and Plantago lanceolata [61, 87] whereby
experiments with whole plants allowed to propose schemes for metabolization of
albendazole, fenbendazole, and flubendazole. As an example of the metabolic
pathway of drugs in plants, the transformation of albendazole in Plantago
Fig. 4 Schematics of identifying unknown metabolites of gemfibrozil in Arabidopsis cells using
stable isotope labeling coupled to high-resolution mass spectrometry. Main steps include (a) create
a mixture of labeled and unlabeled gemfibrozil, (b) expose the gemfibrozil mixture to Arabidopsis
cells, (c) identify metabolite candidates, and (d) elucidate structure of metabolites. Reprinted with
permission from [63]. Copyright (2018) American Chemical Society
Analytical Approaches for the Determination and Identification of Drug. . .
515