Table 1
(continued)
Parent drug(s)
Metabolites
Plant material
Growing conditions
Extraction/cleanup/
enrichment
Analysis of
extracts
Ref.
Phase
I
Phase
II
SMX
x
x
Cucumber
– plant,
Arabidopsis thaliana
–
cell suspension
Cells grown in medium (SMX
1 mg L
‑1
)
Hydroponic (SMX 1 mg L
À1
)
Liquid extraction of freezedried samples
SPE with Oasis HLB
UPLCQqQ-MS
2
LC-TOFMS
[42]
TCS
x
x
Freshwater algae
–
plant
Grown in culture medium
Liquid extraction with
sonication
UPLCQqQ-MS
2
[88]
TCS
x
x
Horseradish
– hairy
root culture
Grown in Murashige and
Skoog culture medium (TCS
0.6 mg L
À1
)
Samples ground in liquid
nitrogen and extracted with
liquid extraction
UPLCQTOF-MS
[56]
TCS
x
x
Carrot
– plant, cell
suspension
Grown in culture medium (TCS
1 mg L
‑1
)
Carrot grown on soil (TCS
3 mg kg
À1
)
Liquid extraction of cells
QuEChERS for carrots
GC-MS
LC-QTrapMS
LC-QTOFMS
2
[51]
17α-E2
17α-estradiol, 17β-E2
17β-estradiol, ALB
albendazole, ATE
atenolol, ATR
atorvastatin, AVO
avobenzone, BHT
butylated hydroxytoluene, BMS
betamethasone dipropionate, BPA
bisphenol A, BZP
benzophenone, CAF
caffeine, CBZ
carbamazepine, CDP
chlordiazepoxide, CIP
ciprofloxacin, CLA
clarithromycin, CLI
clindamycin, CLP
clomipramine, CP
clonazepam, DCF
diclofenac, DP
diazepam, E1
estrone, EE2
ethinylestradiol, ENR
enrofloxacin,
FAD
furaltadone, FAZ
furazolidone, FBZ
fenbendazole, FL
fluvastatin, FLD
fluorescence detector, FLU
flubendazole, FP
flurazepam, FT-ICR
Fourier
transform ion cyclotron resonance, GC
gas chromatography, GEM
gemfibrozil, HCCA
α-cyano-4-hydroxycinnamic acid, IBU
ibuprofen, IPR
iopromide, IT
ion trap, KPF
ketoprofen, LTG
lamotrigine, MeBT
5-methyl-1H-benzotriazole, MePB
methylparaben, MET
metformin, MFA
mefenamic acid, NDP
nordiazepam, NFA
nitrofurantoin, NFZ
nitrofurazone, NPX
naproxen, OBZ
oxybenzone, OC
octocrylene, OFL
ofloxacin, OP
oxazepam, OPL
4-octylphenol, OS
octisalate, PAR
paracetamol, PZE
phenazone, SDM
sulfadimethoxine, SDZ
sulfadiazine, SER
sertraline, SIM
simvastatin, SMR
sulfamerazine, SMT
sulfamethizole, SMX
sulfamethoxazole, SMZ
sulfamethazine, SPD
sulfapyridine, STZ
sulfathiazole, TA
temazepam, TCP
tris(2-chloroethyl)phosphate, TCS
triclosan, TEL
telmisartan, TM
triazolam, TMP
trimethoprim, TRZ
trazodone
510
F. Mlynek et al.
(continued)
Parent drug(s)
Metabolites
Plant material
Growing conditions
Extraction/cleanup/
enrichment
Analysis of
extracts
Ref.
Phase
I
Phase
II
SMX
x
x
Cucumber
– plant,
Arabidopsis thaliana
–
cell suspension
Cells grown in medium (SMX
1 mg L
‑1
)
Hydroponic (SMX 1 mg L
À1
)
Liquid extraction of freezedried samples
SPE with Oasis HLB
UPLCQqQ-MS
2
LC-TOFMS
[42]
TCS
x
x
Freshwater algae
–
plant
Grown in culture medium
Liquid extraction with
sonication
UPLCQqQ-MS
2
[88]
TCS
x
x
Horseradish
– hairy
root culture
Grown in Murashige and
Skoog culture medium (TCS
0.6 mg L
À1
)
Samples ground in liquid
nitrogen and extracted with
liquid extraction
UPLCQTOF-MS
[56]
TCS
x
x
Carrot
– plant, cell
suspension
Grown in culture medium (TCS
1 mg L
‑1
)
Carrot grown on soil (TCS
3 mg kg
À1
)
Liquid extraction of cells
QuEChERS for carrots
GC-MS
LC-QTrapMS
LC-QTOFMS
2
[51]
17α-E2
17α-estradiol, 17β-E2
17β-estradiol, ALB
albendazole, ATE
atenolol, ATR
atorvastatin, AVO
avobenzone, BHT
butylated hydroxytoluene, BMS
betamethasone dipropionate, BPA
bisphenol A, BZP
benzophenone, CAF
caffeine, CBZ
carbamazepine, CDP
chlordiazepoxide, CIP
ciprofloxacin, CLA
clarithromycin, CLI
clindamycin, CLP
clomipramine, CP
clonazepam, DCF
diclofenac, DP
diazepam, E1
estrone, EE2
ethinylestradiol, ENR
enrofloxacin,
FAD
furaltadone, FAZ
furazolidone, FBZ
fenbendazole, FL
fluvastatin, FLD
fluorescence detector, FLU
flubendazole, FP
flurazepam, FT-ICR
Fourier
transform ion cyclotron resonance, GC
gas chromatography, GEM
gemfibrozil, HCCA
α-cyano-4-hydroxycinnamic acid, IBU
ibuprofen, IPR
iopromide, IT
ion trap, KPF
ketoprofen, LTG
lamotrigine, MeBT
5-methyl-1H-benzotriazole, MePB
methylparaben, MET
metformin, MFA
mefenamic acid, NDP
nordiazepam, NFA
nitrofurantoin, NFZ
nitrofurazone, NPX
naproxen, OBZ
oxybenzone, OC
octocrylene, OFL
ofloxacin, OP
oxazepam, OPL
4-octylphenol, OS
octisalate, PAR
paracetamol, PZE
phenazone, SDM
sulfadimethoxine, SDZ
sulfadiazine, SER
sertraline, SIM
simvastatin, SMR
sulfamerazine, SMT
sulfamethizole, SMX
sulfamethoxazole, SMZ
sulfamethazine, SPD
sulfapyridine, STZ
sulfathiazole, TA
temazepam, TCP
tris(2-chloroethyl)phosphate, TCS
triclosan, TEL
telmisartan, TM
triazolam, TMP
trimethoprim, TRZ
trazodone
510
F. Mlynek et al.