Mexico: occurrence and environmental risk assessment. Sci Total Environ
613-614:1263–1274. https://doi.org/10.1016/j.scitotenv.2017.09.134
40. Yang Y, Ok YS, Kim K-H, Kwon EE, Tsang YF (2017) Occurrences and removal of
pharmaceuticals and personal care products (PPCPs) in drinking water and water/sewage
treatment plants: a review. Sci Total Environ 596-597:303–320. https://doi.org/10.1016/j.
scitotenv.2017.04.102
41. López-Serna R, Pérez S, Ginebreda A, Petrović M, Barceló D (2010) Fully automated
determination of 74 pharmaceuticals in environmental and waste waters by online solid
phase extraction-liquid chromatography- electrospray-tandem mass spectrometry. Talanta 83
(2):410–424. https://doi.org/10.1016/j.talanta.2010.09.046
42. Osorio V, Marce R, Perez S, Ginebreda A, Cortina JL, Barcelo D (2012) Occurrence and
modeling of pharmaceuticals on a sewage-impacted Mediterranean river and their dynamics
under different hydrological conditions. Sci Total Environ 440:3–13. https://doi.org/10.1016/j.
scitotenv.2012.08.040
43. Mendoza A, Aceña J, Pérez S, De Alda ML, Barceló D, Gil A, Valcárcel Y (2015) Pharmaceuticals and iodinated contrast media in a hospital wastewater: a case study to analyse their
presence and characterise their environmental risk and hazard. Environ Res 140:225–241
44. Water U (2017) The United Nations world water development report 2017: wastewater the
untapped resource. UNESCO, Paris
45. Daughton CG (2013) Pharmaceuticals in the environment: sources and their management. In:
Comprehensive analytical chemistry, vol 62. Elsevier, New York, pp 37–69
46. Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat
Toxicol 76(2):122–159
47. Oliveira TS, Al Aukidy M, Verlicchi P (2017) Occurrence of common pollutants and
pharmaceuticals in hospital effluents. In: Hospital wastewaters. Springer, Cham, pp 17–32
48. Ginebreda A, Pérez S, Rivas D, Kuzmanovic M, Barceló D (2015) Pollutants of emerging
concern in rivers of catalonia: occurrence, fate, and risk. In: Experiences from surface water
quality monitoring. Springer, Cham, pp 283–320
49. Daughton CG (2004) Non-regulated water contaminants: emerging research. Environ Impact
Assess Rev 24(7–8):711–732
50. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002)
Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999À
2000: a national reconnaissance. Environ Sci Technol 36(6):1202–1211
51. Zwiener C (2007) Occurrence and analysis of pharmaceuticals and their transformation
products in drinking water treatment. Anal Bioanal Chem 387(4):1159–1162
52. Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and
wastewater environments. Anal Bioanal Chem 387(4):1225–1234
53. Daughton CG (2003) Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future
directions. Environ Health Perspect 111(5):775–785
54. Hughes SR, Kay P, Brown LE (2013) Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems. Environ Sci Technol 47(2):661–677
55. Guo J, Sinclair CJ, Selby K, Boxall AB (2016) Toxicological and ecotoxicological risk-based
prioritization of pharmaceuticals in the natural environment. Environ Toxicol Chem 35
(6):1550–1559
56. Castiglioni S, Bagnati R, Fanelli R, Pomati F, Calamari D, Zuccato E (2006) Removal of
pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40(1):357–363
57. Chiffre A, Degiorgi F, Buleté A, Spinner L, Badot P-M (2016) Occurrence of pharmaceuticals
in WWTP effluents and their impact in a karstic rural catchment of eastern France. Environ Sci
Pollut Res 23(24):25427–25441
58. Gros M, Rodriguez-Mozaz S, Barcelo D (2012) Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in
surface and treated waters by ultra-high-performance liquid chromatography coupled to
28
N. Montemurro et al.
613-614:1263–1274. https://doi.org/10.1016/j.scitotenv.2017.09.134
40. Yang Y, Ok YS, Kim K-H, Kwon EE, Tsang YF (2017) Occurrences and removal of
pharmaceuticals and personal care products (PPCPs) in drinking water and water/sewage
treatment plants: a review. Sci Total Environ 596-597:303–320. https://doi.org/10.1016/j.
scitotenv.2017.04.102
41. López-Serna R, Pérez S, Ginebreda A, Petrović M, Barceló D (2010) Fully automated
determination of 74 pharmaceuticals in environmental and waste waters by online solid
phase extraction-liquid chromatography- electrospray-tandem mass spectrometry. Talanta 83
(2):410–424. https://doi.org/10.1016/j.talanta.2010.09.046
42. Osorio V, Marce R, Perez S, Ginebreda A, Cortina JL, Barcelo D (2012) Occurrence and
modeling of pharmaceuticals on a sewage-impacted Mediterranean river and their dynamics
under different hydrological conditions. Sci Total Environ 440:3–13. https://doi.org/10.1016/j.
scitotenv.2012.08.040
43. Mendoza A, Aceña J, Pérez S, De Alda ML, Barceló D, Gil A, Valcárcel Y (2015) Pharmaceuticals and iodinated contrast media in a hospital wastewater: a case study to analyse their
presence and characterise their environmental risk and hazard. Environ Res 140:225–241
44. Water U (2017) The United Nations world water development report 2017: wastewater the
untapped resource. UNESCO, Paris
45. Daughton CG (2013) Pharmaceuticals in the environment: sources and their management. In:
Comprehensive analytical chemistry, vol 62. Elsevier, New York, pp 37–69
46. Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat
Toxicol 76(2):122–159
47. Oliveira TS, Al Aukidy M, Verlicchi P (2017) Occurrence of common pollutants and
pharmaceuticals in hospital effluents. In: Hospital wastewaters. Springer, Cham, pp 17–32
48. Ginebreda A, Pérez S, Rivas D, Kuzmanovic M, Barceló D (2015) Pollutants of emerging
concern in rivers of catalonia: occurrence, fate, and risk. In: Experiences from surface water
quality monitoring. Springer, Cham, pp 283–320
49. Daughton CG (2004) Non-regulated water contaminants: emerging research. Environ Impact
Assess Rev 24(7–8):711–732
50. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002)
Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999À
2000: a national reconnaissance. Environ Sci Technol 36(6):1202–1211
51. Zwiener C (2007) Occurrence and analysis of pharmaceuticals and their transformation
products in drinking water treatment. Anal Bioanal Chem 387(4):1159–1162
52. Nikolaou A, Meric S, Fatta D (2007) Occurrence patterns of pharmaceuticals in water and
wastewater environments. Anal Bioanal Chem 387(4):1225–1234
53. Daughton CG (2003) Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future
directions. Environ Health Perspect 111(5):775–785
54. Hughes SR, Kay P, Brown LE (2013) Global synthesis and critical evaluation of pharmaceutical data sets collected from river systems. Environ Sci Technol 47(2):661–677
55. Guo J, Sinclair CJ, Selby K, Boxall AB (2016) Toxicological and ecotoxicological risk-based
prioritization of pharmaceuticals in the natural environment. Environ Toxicol Chem 35
(6):1550–1559
56. Castiglioni S, Bagnati R, Fanelli R, Pomati F, Calamari D, Zuccato E (2006) Removal of
pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40(1):357–363
57. Chiffre A, Degiorgi F, Buleté A, Spinner L, Badot P-M (2016) Occurrence of pharmaceuticals
in WWTP effluents and their impact in a karstic rural catchment of eastern France. Environ Sci
Pollut Res 23(24):25427–25441
58. Gros M, Rodriguez-Mozaz S, Barcelo D (2012) Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in
surface and treated waters by ultra-high-performance liquid chromatography coupled to
28
N. Montemurro et al.