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86. Chen F, Schnick S, Schröder P (2018) Concentration effects of the UV filter oxybenzone in
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Metabolism of Pharmaceuticals in Plants and Their Associated Microbiota
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pump in the vacuolar membrane of plants. Nature 364:247–249
72. Huber C, Preis M, Harvey PJ et al (2015) Emerging pollutants and plants – metabolic
activation of diclofenac by peroxidases. Chemosphere 146:435–441. https://doi.org/10.1016/
j.chemosphere.2015.12.059
73. González PS, Ontañon OM, Armendariz AL et al (2013) Brassica napus hairy roots and
rhizobacteria for phenolic compounds removal. Environ Sci Pollut Res 20:1310–1317. https://
doi.org/10.1007/s11356-012-1173-9
74. Gujarathi NP, Haney BJ, Park HJ et al (2005) Hairy roots of Helianthus annuus: a model
system to study phytoremediation of tetracycline and oxytetracycline. Biotechnol Prog
21:775–780. https://doi.org/10.1021/bp0496225
75. Lamoureux GL, Rusness DG (1993) Glutathione in the metabolism and detoxification of the
xenobiotics in plants. In: De Kok LJ, Stulen I, Rennenberg H, Brunold C, Rauser W (eds)
Sulfur nutrition and assimilation in higher plants. SPB Academic Press, The Hague, pp 221–
239
76. Ertunç T, Schmidt B, Kühn H et al (2004) Investigation on the chemical structure of
nonextractable residues of the fungicide cyprodinil in spring wheat using 13C-C 1-phenylcyprodinil on 13C-depleted plants: an alternative approach to investigate nonextractable
residues. J Environ Sci Health B 39:689–707
77. Brazier-Hicks M, Offen WA, Gershater MC et al (2007) Characterization and engineering of
the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants.
Proc Ntl Acad Sci USA 104:20238–20243
78. Klampfl CW (2019) Metabolization of pharmaceuticals by plants after uptake from water and
soil: a review. Trends Anal Chem 111:13–26. https://doi.org/10.1016/j.trac.2018.11.042
79. Madikizela LM, Ncube S, Chimuka L (2018) Uptake of pharmaceuticals by plants grown
under hydroponic conditions and natural occurring plant species: a review. Sci Total Environ
636:477–486. https://doi.org/10.1016/j.scitotenv.2018.04.297
80. Wu X, Fu Q, Gan J (2016) Metabolism of pharmaceutical and personal care products by carrot
cell cultures. Environ Pollut 211:141–147. https://doi.org/10.1016/j.envpol.2015.12.050
81. Stuchlíková L, Jirásko R, Skálová L et al (2016) Chemosphere metabolic pathways of
benzimidazole anthelmintics in harebell (Campanula rotundifolia). Chemosphere 157:10–17.
https://doi.org/10.1016/j.chemosphere.2016.05.015
82. Raisová L, Skálová L, Szotáková B, Vok I (2018) Ecotoxicology and environmental safety
biotransformation of flubendazole and fenbendazole and their effects in the ribwort plantain
(Plantago lanceolata). Ecotoxicol Environ Safe 147:681–687. https://doi.org/10.1016/j.
ecoenv.2017.09.020
83. Stuchlíková Raisová L, Podlipná R, Szotáková B et al (2017) Evaluation of drug uptake and
deactivation in plant: fate of albendazole in ribwort plantain (Plantago laceolata) cells and
regenerants. Ecotox Environ Safe 141:37–42. https://doi.org/10.1016/j.ecoenv.2017.03.014
84. Frear D, Swanson H (1975) Metabolism of cisanilide by excised leaves and cell suspension
cultures of carrot and cotton. Pestic Biochem Physiol 5:73–80
85. Lamoureux G, Shimabukuro R, Swanson H, Frear D (1970) Metabolism of 2-Chloro-4Ethylamino-6-Isopropylamino-s-Triazine (atrazine) in excised shorgum leaf sections. J Agric
Food Chem 18:81–86
86. Chen F, Schnick S, Schröder P (2018) Concentration effects of the UV filter oxybenzone in
Cyperus alternifolius: assessment of tolerance by stress-related response. Environ Sci Pollut
Res Int 25:16080–16090. https://doi.org/10.1007/s11356-018-1839-z
87. Card ML, Schnoor JL, Chin Y (2013) Transformation of natural and synthetic estrogens by
maize seedlings. Environ Sci Technol 47:5101–5108. https://doi.org/10.1021/es3040335
88. Riemenschneider C, Al-Raggad M, Moeder M et al (2016) Pharmaceuticals, their metabolites,
and other polar pollutants in field-grown vegetables irrigated with treated municipal wastewater. J Agric Food Chem 64:5784–5792. https://doi.org/10.1021/acs.jafc.6b01696
Metabolism of Pharmaceuticals in Plants and Their Associated Microbiota
261