evident in the identification of 10,11-dihydro-10-hydroxy-11-GSH-CBZ in roots
inoculated with R. radiobacter [29]. The formation of this metabolite can be
rationalized by the ring opening of the epoxide through addition of GSH as depicted
in Fig. 10. The detoxification capabilities of GST were also proven for Typha
latifolia (bulrush) upon exposure to DCF. In root tissues, the cytosolic
GST-CDNB (1-chloro-2,4-dinitrobenzene) activity was significantly increased
forming 4-OH-DCF-GSH through reaction of GSH with the active metabolite
4-OH-DCF [38].
Fig. 9 Proposed metabolic pathways in humans and plants of acetaminophen. Adapted from [26]
Fig. 10 Formation of 10,11-dihydro-10-hydroxy-11-GSH-CBZ in roots inoculated with
R. radiobacter [29]
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