48. Lelandais-Brière C, Jovanovic M, Torres GAM, Perrin Y, Lemoine R, Corre-Menguy F,
Hartmann C (2007) Disruption of AtOCT1, an organic cation transporter gene, affects root
development and carnitine-related responses in Arabidopsis. Plant J 51:154–164. https://doi.
org/10.1111/j.1365-313X.2007.03131.x
49. Küfner I, Koch W (2008) Stress regulated members of the plant organic cation transporter
family are localized to the vacuolar membrane. BMC Res Notes 1:43. https://doi.org/10.1186/
1756-0500-1-43
50. Cui H, Hense BA, Müller J, Schröder P (2015) Short term uptake and transport process for
metformin in roots of Phragmites australis and Typha latifolia. Chemosphere 134:307–312.
https://doi.org/10.1016/j.chemosphere.2015.04.072
51. Dodgen LK, Ueda A, Wu X, Parker DR, Gan J (2015) Effect of transpiration on plant
accumulation and translocation of PPCP/EDCs. Environ Pollut 198:144–153. https://doi.org/
10.1016/j.envpol.2015.01.002
52. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48:9325. https://doi.org/10.1021/es5017894
53. Shenker M, Harush D, Ben-Ari J, Chefetz B (2011) Uptake of carbamazepine by cucumber
plants – a case study related to irrigation with reclaimed wastewater. Chemosphere. https://doi.
org/10.1016/j.chemosphere.2010.10.052
54. Tanoue R, Sato Y, Motoyama M, Nakagawa S, Shinohara R, Nomiyama K (2012) Plant
uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed
wastewater. J Agric Food Chem. https://doi.org/10.1021/jf303142t
55. Bromilow RH, Chamberlain K (2000) The herbicide glyphosate and related molecules:
physicochemical and structural factors determining their mobility in phloem. Pest Manag
Sci
56:368–373.
https://doi.org/10.1002/(SICI)1526-4998(200004)56:4<368::AIDPS153>3.0.CO;2-V
56. Grangeot M, Chauvel B, Gauvrit C (2006) Spray retention, foliar uptake and translocation of
glufosinate and glyphosate in Ambrosia artemisiifolia. Weed Res 46:152–162. https://doi.org/
10.1111/j.1365-3180.2006.00495.x
57. Hsu FC, Kleier DA (1996) Phloem mobility of xenobiotics VIII. A short review. J Exp Bot
47:1265–1271. https://doi.org/10.1093/jxb/47.special_issue.1265
58. McGinnis M, Sun C, Dudley S, Gan J (2019) Effect of low-dose, repeated exposure of
contaminants of emerging concern on plant development and hormone homeostasis. Environ
Pollut 252:706–714. https://doi.org/10.1016/j.envpol.2019.05.159
59. Sur R, Stork A (2003) Uptake, translocation and metabolism of imidacloprid in plants. Bull
Insectol 56:35–40
60. Bromilow RH, Chamberlain K, Evans AA (1990) Physicochemical aspects of phloem translocation of herbicides. Weed Sci 38:305–314. https://doi.org/10.1017/S0043174500056575
61. Dettenmaier EM, Doucette WJ, Bugbee B (2009) Chemical hydrophobicity and uptake by
plant roots. Environ Sci Technol 43:324–329. https://doi.org/10.1021/es801751x
62. Garvin N, Doucette WJ, White JC (2015) Investigating differences in the root to shoot transfer
and xylem sap solubility of organic compounds between zucchini, squash and soybean using a
pressure chamber method. Chemosphere 130:98–102. https://doi.org/10.1016/j.chemosphere.
2014.11.075
63. Weigel HJ, Weis E (1984) Determination of the proton concentration difference across the
tonoplast membrane of isolated vacuoles by means of (-amino fluorescence. Plant Sci Lett
33:163–175. https://doi.org/10.1016/0304-4211(84)90006-3
64. Nason SL, Miller EL, Karthikeyan KG, Pedersen JA (2018) Plant-induced changes to rhizosphere pH impact leaf accumulation of lamotrigine but not carbamazepine. Environ Sci
Technol Lett 5:377–381. https://doi.org/10.1021/acs.estlett.8b00246
65. Cui H, Schröder P (2016) Uptake, translocation and possible biodegradation of the antidiabetic
agent metformin by hydroponically grown Typha latifolia. J Hazard Mater 308:355–361.
https://doi.org/10.1016/j.jhazmat.2016.01.054
Uptake and Translocation of Pharmaceuticals in Plants:. . .
135
Hartmann C (2007) Disruption of AtOCT1, an organic cation transporter gene, affects root
development and carnitine-related responses in Arabidopsis. Plant J 51:154–164. https://doi.
org/10.1111/j.1365-313X.2007.03131.x
49. Küfner I, Koch W (2008) Stress regulated members of the plant organic cation transporter
family are localized to the vacuolar membrane. BMC Res Notes 1:43. https://doi.org/10.1186/
1756-0500-1-43
50. Cui H, Hense BA, Müller J, Schröder P (2015) Short term uptake and transport process for
metformin in roots of Phragmites australis and Typha latifolia. Chemosphere 134:307–312.
https://doi.org/10.1016/j.chemosphere.2015.04.072
51. Dodgen LK, Ueda A, Wu X, Parker DR, Gan J (2015) Effect of transpiration on plant
accumulation and translocation of PPCP/EDCs. Environ Pollut 198:144–153. https://doi.org/
10.1016/j.envpol.2015.01.002
52. Malchi T, Maor Y, Tadmor G, Shenker M, Chefetz B (2014) Irrigation of root vegetables with
treated wastewater: evaluating uptake of pharmaceuticals and the associated human health
risks. Environ Sci Technol 48:9325. https://doi.org/10.1021/es5017894
53. Shenker M, Harush D, Ben-Ari J, Chefetz B (2011) Uptake of carbamazepine by cucumber
plants – a case study related to irrigation with reclaimed wastewater. Chemosphere. https://doi.
org/10.1016/j.chemosphere.2010.10.052
54. Tanoue R, Sato Y, Motoyama M, Nakagawa S, Shinohara R, Nomiyama K (2012) Plant
uptake of pharmaceutical chemicals detected in recycled organic manure and reclaimed
wastewater. J Agric Food Chem. https://doi.org/10.1021/jf303142t
55. Bromilow RH, Chamberlain K (2000) The herbicide glyphosate and related molecules:
physicochemical and structural factors determining their mobility in phloem. Pest Manag
Sci
56:368–373.
https://doi.org/10.1002/(SICI)1526-4998(200004)56:4<368::AIDPS153>3.0.CO;2-V
56. Grangeot M, Chauvel B, Gauvrit C (2006) Spray retention, foliar uptake and translocation of
glufosinate and glyphosate in Ambrosia artemisiifolia. Weed Res 46:152–162. https://doi.org/
10.1111/j.1365-3180.2006.00495.x
57. Hsu FC, Kleier DA (1996) Phloem mobility of xenobiotics VIII. A short review. J Exp Bot
47:1265–1271. https://doi.org/10.1093/jxb/47.special_issue.1265
58. McGinnis M, Sun C, Dudley S, Gan J (2019) Effect of low-dose, repeated exposure of
contaminants of emerging concern on plant development and hormone homeostasis. Environ
Pollut 252:706–714. https://doi.org/10.1016/j.envpol.2019.05.159
59. Sur R, Stork A (2003) Uptake, translocation and metabolism of imidacloprid in plants. Bull
Insectol 56:35–40
60. Bromilow RH, Chamberlain K, Evans AA (1990) Physicochemical aspects of phloem translocation of herbicides. Weed Sci 38:305–314. https://doi.org/10.1017/S0043174500056575
61. Dettenmaier EM, Doucette WJ, Bugbee B (2009) Chemical hydrophobicity and uptake by
plant roots. Environ Sci Technol 43:324–329. https://doi.org/10.1021/es801751x
62. Garvin N, Doucette WJ, White JC (2015) Investigating differences in the root to shoot transfer
and xylem sap solubility of organic compounds between zucchini, squash and soybean using a
pressure chamber method. Chemosphere 130:98–102. https://doi.org/10.1016/j.chemosphere.
2014.11.075
63. Weigel HJ, Weis E (1984) Determination of the proton concentration difference across the
tonoplast membrane of isolated vacuoles by means of (-amino fluorescence. Plant Sci Lett
33:163–175. https://doi.org/10.1016/0304-4211(84)90006-3
64. Nason SL, Miller EL, Karthikeyan KG, Pedersen JA (2018) Plant-induced changes to rhizosphere pH impact leaf accumulation of lamotrigine but not carbamazepine. Environ Sci
Technol Lett 5:377–381. https://doi.org/10.1021/acs.estlett.8b00246
65. Cui H, Schröder P (2016) Uptake, translocation and possible biodegradation of the antidiabetic
agent metformin by hydroponically grown Typha latifolia. J Hazard Mater 308:355–361.
https://doi.org/10.1016/j.jhazmat.2016.01.054
Uptake and Translocation of Pharmaceuticals in Plants:. . .
135