Ali I, Suhail M, Lone MN, Alothman ZA, Alwarthan A (2016e) Chiral resolution of multichiral
Centre racemates by different modalities of chromatography. J Liq Chromatogr Relat Technol
39(9):435–444
Ariens EJ (1993) Nonchiral, homochiral and composite chiral drugs. Trends Pharmacol Sci 14
(2):68–75
Bagnall JP, Evans SE, Wort MT, Lubben AT, Kasprzyk-Hordern B (2012) Using chiral liquid
chromatography quadrupole time-of-flight mass spectrometry for the analysis of pharmaceuticals and illicit drugs in surface and wastewater at the enantiomeric level. J Chromatogr A
1249:115–129
Baker DR, Kasprzyk-Hordern B (2013) Spatial and temporal occurrence of pharmaceuticals and
illicit drugs in the aqueous environment and during wastewater treatment: new developments.
Sci Total Environ 454-455:442–456
Basheer AA (2018) Chemical chiral pollution: impact on the society and science and need of the
regulations in the 21(st) century. Chirality 30(4):402–406
Bidleman TF, Leone AD, Falconer RL, Harner T, Jantunen LM, Wiberg K, Helm PA, Diamond
ML, Loo B (2002) Chiral pesticides in soil and water and exchange with the atmosphere. Sci
World J 2:357–373
Caballo C, Sicilia MD, Rubio S (2015) Enantioselective determination of representative profens in
wastewater by a single-step sample treatment and chiral liquid chromatography-tandem mass
spectrometry. Talanta 134:325–332
Camacho-Munoz D, Petrie B, Castrignano E, Kasprzyk-Hordern B (2016) Enantiomeric profiling
of chiral pharmacologically active compounds in the environment with the usage of chiral liquid
chromatography coupled with tandem mass spectrometry. Curr Anal Chem 12(4):303–314
Camacho-Munoz D, Petrie B, Lopardo L, Proctor K, Rice J, Youdan J, Barden R, KasprzykHordern B (2019) Stereoisomeric profiling of chiral pharmaceutically active compounds in
wastewaters and the receiving environment – a catchment-scale and a laboratory study. Environ
Int 127:558–572
Campbell DB (1990) The development of chiral drugs. Acta Pharm Nord 2(3):217–226
Carlsson P, Warner NA, Hallanger IG, Herzke D, Kallenborn R (2014) Spatial and temporal
distribution of chiral pesticides in Calanus spp. from three Arctic fjords. Environ Pollut
192:154–161
Chen J, Ding G, Yue C, Tang A (2012) New technique for nanoparticle capillary electrophoresis/
microfluidic chip and its uses in enantioselective separation. Se Pu 30(1):3–7
Coelho MM, Lado Ribeiro AR, Sousa JCG, Ribeiro C, Fernandes C, Silva AMT, Tiritan ME (2019)
Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: monitoring
in Douro River estuary. J Pharm Biomed Anal 170:89–101
Connors KA, Du B, Fitzsimmons PN, Chambliss CK, Nichols JW, Brooks BW (2013) Enantiomerspecific in vitro biotransformation of select pharmaceuticals in rainbow trout (Oncorhynchus
mykiss). Chirality 25(11):763–767
De Camp WH (1993) Chiral drugs: the FDA perspective on manufacturing and control. J Pharm
Biomed Anal 11(11–12):1167–1172
Ding F, Peng W, Peng YK, Liu BQ (2020) Estimating the potential toxicity of chiral diclofopmethyl: mechanistic insight into the enantioselective behavior. Toxicology 438:152446
Dolowy M, Pyka A (2014) Application of TLC, HPLC and GC methods to the study of amino acid
and peptide enantiomers: a review. Biomed Chromatogr 28(1):84–101
Elbashir AA, Aboul-Enein HY (2018) Multidimensional gas chromatography for chiral analysis.
Crit Rev Anal Chem 48(5):416–427
Elder FCT, Feil EJ, Snape J, Gaze WH, Kasprzyk-Hordern B (2020) The role of stereochemistry of
antibiotic agents in the development of antibiotic resistance in the environment. Environ Int
139:105681
Ernst KH (2010) Amplification of chirality at solid surfaces. Orig Life Evol Biosph 40(1):41–50
314
11 Perspectives
Centre racemates by different modalities of chromatography. J Liq Chromatogr Relat Technol
39(9):435–444
Ariens EJ (1993) Nonchiral, homochiral and composite chiral drugs. Trends Pharmacol Sci 14
(2):68–75
Bagnall JP, Evans SE, Wort MT, Lubben AT, Kasprzyk-Hordern B (2012) Using chiral liquid
chromatography quadrupole time-of-flight mass spectrometry for the analysis of pharmaceuticals and illicit drugs in surface and wastewater at the enantiomeric level. J Chromatogr A
1249:115–129
Baker DR, Kasprzyk-Hordern B (2013) Spatial and temporal occurrence of pharmaceuticals and
illicit drugs in the aqueous environment and during wastewater treatment: new developments.
Sci Total Environ 454-455:442–456
Basheer AA (2018) Chemical chiral pollution: impact on the society and science and need of the
regulations in the 21(st) century. Chirality 30(4):402–406
Bidleman TF, Leone AD, Falconer RL, Harner T, Jantunen LM, Wiberg K, Helm PA, Diamond
ML, Loo B (2002) Chiral pesticides in soil and water and exchange with the atmosphere. Sci
World J 2:357–373
Caballo C, Sicilia MD, Rubio S (2015) Enantioselective determination of representative profens in
wastewater by a single-step sample treatment and chiral liquid chromatography-tandem mass
spectrometry. Talanta 134:325–332
Camacho-Munoz D, Petrie B, Castrignano E, Kasprzyk-Hordern B (2016) Enantiomeric profiling
of chiral pharmacologically active compounds in the environment with the usage of chiral liquid
chromatography coupled with tandem mass spectrometry. Curr Anal Chem 12(4):303–314
Camacho-Munoz D, Petrie B, Lopardo L, Proctor K, Rice J, Youdan J, Barden R, KasprzykHordern B (2019) Stereoisomeric profiling of chiral pharmaceutically active compounds in
wastewaters and the receiving environment – a catchment-scale and a laboratory study. Environ
Int 127:558–572
Campbell DB (1990) The development of chiral drugs. Acta Pharm Nord 2(3):217–226
Carlsson P, Warner NA, Hallanger IG, Herzke D, Kallenborn R (2014) Spatial and temporal
distribution of chiral pesticides in Calanus spp. from three Arctic fjords. Environ Pollut
192:154–161
Chen J, Ding G, Yue C, Tang A (2012) New technique for nanoparticle capillary electrophoresis/
microfluidic chip and its uses in enantioselective separation. Se Pu 30(1):3–7
Coelho MM, Lado Ribeiro AR, Sousa JCG, Ribeiro C, Fernandes C, Silva AMT, Tiritan ME (2019)
Dual enantioselective LC-MS/MS method to analyse chiral drugs in surface water: monitoring
in Douro River estuary. J Pharm Biomed Anal 170:89–101
Connors KA, Du B, Fitzsimmons PN, Chambliss CK, Nichols JW, Brooks BW (2013) Enantiomerspecific in vitro biotransformation of select pharmaceuticals in rainbow trout (Oncorhynchus
mykiss). Chirality 25(11):763–767
De Camp WH (1993) Chiral drugs: the FDA perspective on manufacturing and control. J Pharm
Biomed Anal 11(11–12):1167–1172
Ding F, Peng W, Peng YK, Liu BQ (2020) Estimating the potential toxicity of chiral diclofopmethyl: mechanistic insight into the enantioselective behavior. Toxicology 438:152446
Dolowy M, Pyka A (2014) Application of TLC, HPLC and GC methods to the study of amino acid
and peptide enantiomers: a review. Biomed Chromatogr 28(1):84–101
Elbashir AA, Aboul-Enein HY (2018) Multidimensional gas chromatography for chiral analysis.
Crit Rev Anal Chem 48(5):416–427
Elder FCT, Feil EJ, Snape J, Gaze WH, Kasprzyk-Hordern B (2020) The role of stereochemistry of
antibiotic agents in the development of antibiotic resistance in the environment. Environ Int
139:105681
Ernst KH (2010) Amplification of chirality at solid surfaces. Orig Life Evol Biosph 40(1):41–50
314
11 Perspectives