505
77. Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther. 2016;158:52–62.
78. Morales U, Gabriel C. Productos antiobesidad sobre el peso, bioquímica sanguínea, biometría,
deposición de grasa y expresión génica en ratas Holtzman inducidas a obesidad. 2018.
79. Rajesh P, Balasubramanian K. Gestational exposure to di (2-ethylhexyl) phthalate (DEHP)
impairs pancreatic β-cell function in F1 rat offspring. Toxicol Lett. 2015;232(1):46–57.
80. Gundogdu M, Muradoglu F, Sensoy RG, Yilmaz H. Determination of fruit chemical properties
of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC. Sci Hortic. 2011;132:37–41.
81. Heo HJ, Lee CYL. Phenolic phytochemicals in cabbage inhibit amyloid β protein-induced
neurotoxicity. LWT - Food Sci Technol. 2006;39(4):331–7.
82. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P, et al. Sulforaphane as
a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell
Longev. 2013;2013:415078.
83. Wiczkowski W, Szawara-Nowak D, Topolska J. Red cabbage anthocyanins: profile, isolation,
identification, and antioxidant activity. Food Res Int. 2013;51(1):303–9.
84. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and
insulin-resistant states. Diabetes. 2006;55(8):2256–64.
85. García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as
anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res.
2009;58(9):537–52.
86. Van De Wier B, Koek GH, Bast A, Haenen GRMM. The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Crit Rev Food Sci Nutr. 2017;57(4):834–55.
87. Seo D-B, Jeong HW, Lee S-J, Lee S-J. Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells. J Agric Food Chem. 2014;62(19):4298–305.
88. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature.
2009;458(7241):1056.
89. Jiang X, Tang X, Zhang P, Liu G, Guo H. Cyanidin-3-O-β-glucoside protects primary mouse
hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction
and the PI3K/Akt pathway. Biochem Pharmacol. 2014;90(2):135–44.
90. Sjögren M, Ehrenberg L, Rannug U. Relevance of different biological assays in assessing
initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency. Mutat Res. 1996;358(1):97–112.
91. Newbold RR, Padilla-Banks E, Snyder RJ, Jefferson WN. Perinatal exposure to environmental
estrogens and the development of obesity. Mol Nutr Food Res. 2007;51(7):912–7.
92. Ruijters EJ, Haenen GR, Weseler AR, Bast A. The cocoa flavanol (−)-epicatechin protects the
cortisol response. Pharmacol Res. 2014;79:28–33.
93. Paquay JB, Haenen GR, Stender G, Wiseman SA, Tijburg LB, Bast A, et al. Protection against
nitric oxide toxicity by tea. J Agric Food Chem. 2000;48(11):5768–72.
94. Masterjohn C, Bruno RS. Therapeutic potential of green tea in nonalcoholic fatty liver disease.
Nutr Rev. 2012;70(1):41–56.
95. Sharma S, Ali A, Ali J, Sahni JK, Baboota S. Rutin: therapeutic potential and recent advances
in drug delivery. Expert Opin Investig Drugs. 2013;22(8):1063–79.
28 Bioactive Compounds for the Treatment of Metabolic Disorders
77. Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther. 2016;158:52–62.
78. Morales U, Gabriel C. Productos antiobesidad sobre el peso, bioquímica sanguínea, biometría,
deposición de grasa y expresión génica en ratas Holtzman inducidas a obesidad. 2018.
79. Rajesh P, Balasubramanian K. Gestational exposure to di (2-ethylhexyl) phthalate (DEHP)
impairs pancreatic β-cell function in F1 rat offspring. Toxicol Lett. 2015;232(1):46–57.
80. Gundogdu M, Muradoglu F, Sensoy RG, Yilmaz H. Determination of fruit chemical properties
of Morus nigra L., Morus alba L. and Morus rubra L. by HPLC. Sci Hortic. 2011;132:37–41.
81. Heo HJ, Lee CYL. Phenolic phytochemicals in cabbage inhibit amyloid β protein-induced
neurotoxicity. LWT - Food Sci Technol. 2006;39(4):331–7.
82. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P, et al. Sulforaphane as
a potential protective phytochemical against neurodegenerative diseases. Oxid Med Cell
Longev. 2013;2013:415078.
83. Wiczkowski W, Szawara-Nowak D, Topolska J. Red cabbage anthocyanins: profile, isolation,
identification, and antioxidant activity. Food Res Int. 2013;51(1):303–9.
84. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and
insulin-resistant states. Diabetes. 2006;55(8):2256–64.
85. García-Lafuente A, Guillamón E, Villares A, Rostagno MA, Martínez JA. Flavonoids as
anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm Res.
2009;58(9):537–52.
86. Van De Wier B, Koek GH, Bast A, Haenen GRMM. The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Crit Rev Food Sci Nutr. 2017;57(4):834–55.
87. Seo D-B, Jeong HW, Lee S-J, Lee S-J. Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells. J Agric Food Chem. 2014;62(19):4298–305.
88. Cantó C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature.
2009;458(7241):1056.
89. Jiang X, Tang X, Zhang P, Liu G, Guo H. Cyanidin-3-O-β-glucoside protects primary mouse
hepatocytes against high glucose-induced apoptosis by modulating mitochondrial dysfunction
and the PI3K/Akt pathway. Biochem Pharmacol. 2014;90(2):135–44.
90. Sjögren M, Ehrenberg L, Rannug U. Relevance of different biological assays in assessing
initiating and promoting properties of polycyclic aromatic hydrocarbons with respect to carcinogenic potency. Mutat Res. 1996;358(1):97–112.
91. Newbold RR, Padilla-Banks E, Snyder RJ, Jefferson WN. Perinatal exposure to environmental
estrogens and the development of obesity. Mol Nutr Food Res. 2007;51(7):912–7.
92. Ruijters EJ, Haenen GR, Weseler AR, Bast A. The cocoa flavanol (−)-epicatechin protects the
cortisol response. Pharmacol Res. 2014;79:28–33.
93. Paquay JB, Haenen GR, Stender G, Wiseman SA, Tijburg LB, Bast A, et al. Protection against
nitric oxide toxicity by tea. J Agric Food Chem. 2000;48(11):5768–72.
94. Masterjohn C, Bruno RS. Therapeutic potential of green tea in nonalcoholic fatty liver disease.
Nutr Rev. 2012;70(1):41–56.
95. Sharma S, Ali A, Ali J, Sahni JK, Baboota S. Rutin: therapeutic potential and recent advances
in drug delivery. Expert Opin Investig Drugs. 2013;22(8):1063–79.
28 Bioactive Compounds for the Treatment of Metabolic Disorders