503
33. Tarabra E, Pelengaris S, Khan M. A simple matter of life and death—the trials of postnatal
beta-cell mass regulation. Int J Endocrinol. 2012;2012:516718.
34. Park SA, Choi M-S, Cho S-Y, Seo J-S, Jung UJ, Kim M-J, et al. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci.
2006;79(12):1207–13.
35. Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high
fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complicat. 2012;26(6):483–90.
36. Mahmoud AM, Ahmed OM, Ashour MB, Abdel-Moneim A. In vivo and in vitro antidiabetic
effects of citrus flavonoids; a study on the mechanism of action. Int J Diabetes Dev Countries.
2015;35(3):250–63.
37. Shi X, Liao S, Mi H, Guo C, Qi D, Li F, et al. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules. 2012;17(11):12868–81.
38. Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical
marker to improve nerve functions. Pharm Biol. 2014;52(7):814–28.
39. Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi Pharm J.
2017;25(2):149–64.
40. Yang J, Guo J, Yuan JJL-FS. In vitro antioxidant properties of rutin. LWT-Food Sci Technol.
2008;41(6):1060–6.
41. Ghorbani AJB. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother.
2017;96:305–12.
42. Ahmed OM, Moneim AA, Yazid IA, Mahmoud AM. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetologia Croatica.
2010;39(1):15.
43. Rissanen T, Voutilainen S, Nyyssönen K, Salonen JTJEB. Lycopene, atherosclerosis, and coronary heart disease. Exp Biol Med (Maywood). 2002;227(10):900–7.
44. Ali MM, Agha FG. Amelioration of streptozotocin-induced diabetes mellitus, oxidative stress
and dyslipidemia in rats by tomato extract lycopene. Scand J Clin Lab Invest. 2009;69(3):371–9.
45. Zhu J, Wang C-G, Xu Y-G. Lycopene attenuates endothelial dysfunction in streptozotocininduced diabetic rats by reducing oxidative stress. Pharm Biol. 2011;49(11):1144–9.
46. Li W, Wang G, Lu X, Jiang Y, Xu L, Zhao X, et al. Lycopene ameliorates renal function in rats
with streptozotocin-induced diabetes. Int J Clin Exp Pathol. 2014;7(8):5008.
47. Cai EP, Lin J-K. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity
through activating IRS2 and AMPK signaling in rat pancreatic β cells. J Agric Food Chem.
2009;57(20):9817–27.
48. Bhattacharya I, Saxena R, Saxena R, Lal AM. Vitamin E supplementation and markers of oxidative stress in indian acute myocardial infarction patients. Asian J Med Sci. 2014;5(2):46–53.
49. Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, Vom Saal FS. Components of plastic:
experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B
Biol Sci. 2009;364(1526):2079–96.
50. Andersen HR, Wohlfahrt-Veje C, Dalgård C, Christiansen L, Main KM, Nellemann C, et al.
Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PLoS One. 2012;7(5):e36830.
51. Werner EF, Braun JM, Yolton K, Khoury JC, Lanphear BP. The association between maternal
urinary phthalate concentrations and blood pressure in pregnancy: the home study. Environ
Health. 2015;14(1):75.
52. Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals.
Mol Cell Endocrinol. 2012;355(2):240–8.
53. Monsalve FA, Pyarasani RD, Delgado-Lopez F, Moore-Carrasco R. Peroxisome proliferatoractivated receptor targets for the treatment of metabolic diseases. Mediators Inflamm.
2013;2013:549627.
28 Bioactive Compounds for the Treatment of Metabolic Disorders
33. Tarabra E, Pelengaris S, Khan M. A simple matter of life and death—the trials of postnatal
beta-cell mass regulation. Int J Endocrinol. 2012;2012:516718.
34. Park SA, Choi M-S, Cho S-Y, Seo J-S, Jung UJ, Kim M-J, et al. Genistein and daidzein modulate hepatic glucose and lipid regulating enzyme activities in C57BL/KsJ-db/db mice. Life Sci.
2006;79(12):1207–13.
35. Mahmoud AM, Ashour MB, Abdel-Moneim A, Ahmed OM. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high
fat fed/streptozotocin-induced type 2 diabetic rats. J Diabetes Complicat. 2012;26(6):483–90.
36. Mahmoud AM, Ahmed OM, Ashour MB, Abdel-Moneim A. In vivo and in vitro antidiabetic
effects of citrus flavonoids; a study on the mechanism of action. Int J Diabetes Dev Countries.
2015;35(3):250–63.
37. Shi X, Liao S, Mi H, Guo C, Qi D, Li F, et al. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules. 2012;17(11):12868–81.
38. Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical
marker to improve nerve functions. Pharm Biol. 2014;52(7):814–28.
39. Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi Pharm J.
2017;25(2):149–64.
40. Yang J, Guo J, Yuan JJL-FS. In vitro antioxidant properties of rutin. LWT-Food Sci Technol.
2008;41(6):1060–6.
41. Ghorbani AJB. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother.
2017;96:305–12.
42. Ahmed OM, Moneim AA, Yazid IA, Mahmoud AM. Antihyperglycemic, antihyperlipidemic and antioxidant effects and the probable mechanisms of action of Ruta graveolens infusion and rutin in nicotinamide-streptozotocin-induced diabetic rats. Diabetologia Croatica.
2010;39(1):15.
43. Rissanen T, Voutilainen S, Nyyssönen K, Salonen JTJEB. Lycopene, atherosclerosis, and coronary heart disease. Exp Biol Med (Maywood). 2002;227(10):900–7.
44. Ali MM, Agha FG. Amelioration of streptozotocin-induced diabetes mellitus, oxidative stress
and dyslipidemia in rats by tomato extract lycopene. Scand J Clin Lab Invest. 2009;69(3):371–9.
45. Zhu J, Wang C-G, Xu Y-G. Lycopene attenuates endothelial dysfunction in streptozotocininduced diabetic rats by reducing oxidative stress. Pharm Biol. 2011;49(11):1144–9.
46. Li W, Wang G, Lu X, Jiang Y, Xu L, Zhao X, et al. Lycopene ameliorates renal function in rats
with streptozotocin-induced diabetes. Int J Clin Exp Pathol. 2014;7(8):5008.
47. Cai EP, Lin J-K. Epigallocatechin gallate (EGCG) and rutin suppress the glucotoxicity
through activating IRS2 and AMPK signaling in rat pancreatic β cells. J Agric Food Chem.
2009;57(20):9817–27.
48. Bhattacharya I, Saxena R, Saxena R, Lal AM. Vitamin E supplementation and markers of oxidative stress in indian acute myocardial infarction patients. Asian J Med Sci. 2014;5(2):46–53.
49. Talsness CE, Andrade AJ, Kuriyama SN, Taylor JA, Vom Saal FS. Components of plastic:
experimental studies in animals and relevance for human health. Philos Trans R Soc Lond B
Biol Sci. 2009;364(1526):2079–96.
50. Andersen HR, Wohlfahrt-Veje C, Dalgård C, Christiansen L, Main KM, Nellemann C, et al.
Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age. PLoS One. 2012;7(5):e36830.
51. Werner EF, Braun JM, Yolton K, Khoury JC, Lanphear BP. The association between maternal
urinary phthalate concentrations and blood pressure in pregnancy: the home study. Environ
Health. 2015;14(1):75.
52. Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals.
Mol Cell Endocrinol. 2012;355(2):240–8.
53. Monsalve FA, Pyarasani RD, Delgado-Lopez F, Moore-Carrasco R. Peroxisome proliferatoractivated receptor targets for the treatment of metabolic diseases. Mediators Inflamm.
2013;2013:549627.
28 Bioactive Compounds for the Treatment of Metabolic Disorders