501
References
1. Kris-Etherton PM, Lefevre M, Beecher G, Gross M, Keen CL, Etherton TDJARN. Bioactive
compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. Annu Rev
Nutr. 2004;24:511–38.
2. Dudareva N, Pichersky E. Biochemical and molecular genetic aspects of floral scents. Plant
Physiol. 2000;122(3):627–34.
3. Bernhoft A, Siem H, Bjertness E, Meltzer M, Flaten T, Holmsen E, et al. Bioactive compounds
in plants–benefits and risks for man and animals. Oslo: The Norwegian Academy of Science
and Letters; 2010.
4. Brunati M, Rojas JL, Sponga F, Ciciliato I, Losi D, Göttlich E, et al. Diversity and pharmaceutical screening of fungi from benthic mats of Antarctic lakes. Mar Genomics. 2009;2(1):43–50.
5. Jaiganesh R, Kumar NS. Marine bacterial sources of bioactive compounds. Adv Food Nutr
Res. 2012;65:389–408.
6. Suarez-Jimenez G-M, Burgos-Hernandez A, Ezquerra-Brauer MJ. Bioactive peptides
and depsipeptides with anticancer potential: Sources from marine animals. Mar Drugs.
2012;10(5):963–86.
7. Bowling JJ, Kochanowska AJ, Kasanah N, Hamann MT. Nature’s bounty–drug discovery from
the sea. Expert Opin Drug Discov. 2007;2(11):1505–22.
8. Kelecom A. Secondary metabolites from marine microorganisms. An Acad Bras Cienc.
2002;74(1):151–70.
9. Maria H. Marine bioactive compounds: sources, characterization, and applications. Boston:
Springer; 2012.
10. Bhatnagar I, Kim S-K. Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs. 2010;8(10):2673–701.
11. Šnē E, Galoburda R, Segliņa D. Sea buckthorn vegetative parts–a good source of bioactive
compounds. Proc Latv Acad Sci Sect B. 2013;67(2):101–8.
Table 28.4 Bioactive compounds against EDC’s induced NAFLD
Bioactive compounds Source
Mechanism of action
Therapeutic property
1 Coumestrol
• Brussels
sprouts
• Clover
• Legumes
• Spinach
• Soya beans
Decrease mRNA expression
of lipogenic genes in
hepatocytes
• Antioxidant
2 Anthocyanins
• Berries
• Vegetables
• Fruits
Improve antioxidant status
and inhibiting mitochondrial
pathways of apoptosis
• Antioxidant
3 Curcumin
• Curcuma longa Reduces lipogenesis by
facilitating β-oxidation
• Antioxidant
• Antiinflammatory
• Antimutagenic
4 Astaxanthin
• Crayfish
• Shrimp
• Salmon
• Yeast
Reduces lipid peroxidation
and lipid accumulation in
liver
• Antioxidant
5 Flavonoids
• Green tea
Stimulation of fatty acids
oxidation and inhibition of
lipogenesis
• Antioxidant
28 Bioactive Compounds for the Treatment of Metabolic Disorders
References
1. Kris-Etherton PM, Lefevre M, Beecher G, Gross M, Keen CL, Etherton TDJARN. Bioactive
compounds in nutrition and health-research methodologies for establishing biological function: the antioxidant and anti-inflammatory effects of flavonoids on atherosclerosis. Annu Rev
Nutr. 2004;24:511–38.
2. Dudareva N, Pichersky E. Biochemical and molecular genetic aspects of floral scents. Plant
Physiol. 2000;122(3):627–34.
3. Bernhoft A, Siem H, Bjertness E, Meltzer M, Flaten T, Holmsen E, et al. Bioactive compounds
in plants–benefits and risks for man and animals. Oslo: The Norwegian Academy of Science
and Letters; 2010.
4. Brunati M, Rojas JL, Sponga F, Ciciliato I, Losi D, Göttlich E, et al. Diversity and pharmaceutical screening of fungi from benthic mats of Antarctic lakes. Mar Genomics. 2009;2(1):43–50.
5. Jaiganesh R, Kumar NS. Marine bacterial sources of bioactive compounds. Adv Food Nutr
Res. 2012;65:389–408.
6. Suarez-Jimenez G-M, Burgos-Hernandez A, Ezquerra-Brauer MJ. Bioactive peptides
and depsipeptides with anticancer potential: Sources from marine animals. Mar Drugs.
2012;10(5):963–86.
7. Bowling JJ, Kochanowska AJ, Kasanah N, Hamann MT. Nature’s bounty–drug discovery from
the sea. Expert Opin Drug Discov. 2007;2(11):1505–22.
8. Kelecom A. Secondary metabolites from marine microorganisms. An Acad Bras Cienc.
2002;74(1):151–70.
9. Maria H. Marine bioactive compounds: sources, characterization, and applications. Boston:
Springer; 2012.
10. Bhatnagar I, Kim S-K. Immense essence of excellence: marine microbial bioactive compounds. Mar Drugs. 2010;8(10):2673–701.
11. Šnē E, Galoburda R, Segliņa D. Sea buckthorn vegetative parts–a good source of bioactive
compounds. Proc Latv Acad Sci Sect B. 2013;67(2):101–8.
Table 28.4 Bioactive compounds against EDC’s induced NAFLD
Bioactive compounds Source
Mechanism of action
Therapeutic property
1 Coumestrol
• Brussels
sprouts
• Clover
• Legumes
• Spinach
• Soya beans
Decrease mRNA expression
of lipogenic genes in
hepatocytes
• Antioxidant
2 Anthocyanins
• Berries
• Vegetables
• Fruits
Improve antioxidant status
and inhibiting mitochondrial
pathways of apoptosis
• Antioxidant
3 Curcumin
• Curcuma longa Reduces lipogenesis by
facilitating β-oxidation
• Antioxidant
• Antiinflammatory
• Antimutagenic
4 Astaxanthin
• Crayfish
• Shrimp
• Salmon
• Yeast
Reduces lipid peroxidation
and lipid accumulation in
liver
• Antioxidant
5 Flavonoids
• Green tea
Stimulation of fatty acids
oxidation and inhibition of
lipogenesis
• Antioxidant
28 Bioactive Compounds for the Treatment of Metabolic Disorders