431
• Reversion of multidrug resistance
• Proteins and peptides delivery
• Prevention from premature inactivation during transport
• Cell internalization
• Vaccine delivery
• Controlled release
• Decrease toxicity to healthy cells or tissues
• BBB targeting
• Efficient drug penetration
• Tumor targeting
Polymer
+
Drug
Nano-formulation
formulated by
different techniques
Nanospehere
Nanocapsule
Entrapped
drug
Surface
adsorbed
drug
Entrapped
drug
Surface
adsorbed
drug
Fig. 25.13 Various kinds of NPs
Table 25.3 Summary of earlier investigations on the effects of NPs on several aspects of metabolic
syndrome
Nanocarriers
Results
References
Chitosan nanoparticles
Useful for controlled drug delivery
[121]
PLGA-b-PEG nanoparticles
Prevented gain in body weight
[122]
Chitosan nanoparticles
Effective in lowering body weight and
serum, lipid
[121]
Silver nanoparticles
Reduction in body weight
[123]
Pluronic F68, Squalene
nanostructured lipid carrier
Enhanced clinical efficacy of lovastatin
[124]
Chitosan nanoparticles
For a prolonged time period efficiently
decrease the blood pressure
[125]
Chitosan nanoparticles
Enhanced inhibition of the ACE
[126]
Polylactide nanoparticles
Digestion of LDL
[127]
25 Role of Nanoparticles in the Management of Metabolic Disorders