388
17. Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, Njapau H, et al.
Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ Health Perspect.
2005;113(12):1779–83.
18. Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG. Aflatoxins: a global concern for food
safety, human health and their management. Front Microbiol. 2017;7:2170.
19. Josse R, Dumont J, Fautrel A, Robin M-A, Guillouzo A. Identification of early target genes
of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other
genotoxic compounds. Toxicol Appl Pharmacol. 2012;258(2):176–87.
20. Bondy SC, Naderi S. Contribution of hepatic cytochrome P450 systems to the generation of
reactive oxygen species. Biochem Pharmacol. 1994;48(1):155–9.
21. Kodama M, Inoue F, Akao M. Enzymatic and non-enzymatic formation of free radicals from
aflatoxin B1. Free Radic Res Commun. 1990;10(3):137–42.
22. Qian G, Tang L, Guo X, Wang F, Massey ME, Su J, et al. Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats. J Appl
Toxicol. 2014;34(3):241–9.
23. Mehrzad J, Devriendt B, Baert K, Cox E. Aflatoxin B1 interferes with the antigen-presenting
capacity of porcine dendritic cells. Toxicol In Vitro. 2014;28(4):531–7.
24. Shen HM, Shi CY, Shen Y, Ong CN. Detection of elevated reactive oxygen species level in
cultured rat hepatocytes treated with aflatoxin B1. Free Radic Biol Med. 1996;21(2):139–46.
25. Yilmaz S, Kaya E, Kisacam MA. The effect on oxidative stress of aflatoxin and protective
effect of lycopene on aflatoxin damage. In: Aflatoxin-control, analysis, detection and health
risks. London: IntechOpen; 2017. p. 67–90.
26. Lu X, Hu B, Shao L, Tian Y, Jin T, Jin Y, et al. Integrated analysis of transcriptomics and
metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat. Food Chem Toxicol.
2013;55:444–55.
27. Rotimi OA, Rotimi SO, Duru CU, Ebebeinwe OJ, Abiodun AO, Oyeniyi BO, et al. Acute
aflatoxin B1 - induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein
metabolism in rats. Toxicol Rep. 2017;4:408–14.
28. Shen HM, Ong CN. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res. 1996;366(1):23–44.
29. Sun X, Ai M, Wang Y, Shen S, Gu Y, Jin Y, et al. Selective induction of tumor cell apoptosis
by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl)
propiolate. J Biol Chem. 2013;288(13):8826–37.
30. Hendrickse R. Of sick turkeys, kwashiorkor, malaria, perinatal mortality, heroin addicts and
food poisoning: research on the influence of aflatoxins on child health in the tropics. Ann Trop
Med Parasitol. 1997;91(7):787–93.
31. Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y. Assessment of fatty acid beta
oxidation in cells and isolated mitochondria. Curr Protoc Toxicol. 2014;60:31–9.
32. Tsai F-J, Chen S-Y, Liu Y-C, Liao H-Y, Chen C-J. The comparison of CHCA solvent compositions for improving LC-MALDI performance and its application to study the impact of aflatoxin
B1 on the liver proteome of diabetes mellitus type 1 mice. PLoS One. 2017;12(7):e0181423.
33. Mauro A, Garcia-Cela E, Pietri A, Cotty PJ, Battilani P. Biological control products for aflatoxin prevention in Italy: commercial field evaluation of atoxigenic Aspergillus flavus active
ingredients. Toxins. 2018;10(1):30.
34. Davies B. Drying survey in Kenya: North Rift--AflaSTOP: storage and drying for aflatoxin
prevention. Gates Open Res. 2019;3:1–36.
35. Negash D. A review of aflatoxin: occurrence, prevention, and gaps in both food and feed
safety. J Nutr Health Food Eng. 2018;8:190–7.
36. Bandyopadhyay R, Kumar M, Leslie JF. Relative severity of aflatoxin contamination of cereal
crops in West Africa. Food Addit Contam. 2007;24(10):1109–14.
37. Phillips TD, Afriyie-Gyawu E, Williams J, Huebner H, Ankrah NA, Ofori-Adjei D, et al.
Reducing human exposure to aflatoxin through the use of clay: a review. Food Addit Contam
Part A Chem Anal Control Expo Risk Assess. 2008;25(2):134–45.
S. Sabir et al.
17. Azziz-Baumgartner E, Lindblade K, Gieseker K, Rogers HS, Kieszak S, Njapau H, et al.
Case-control study of an acute aflatoxicosis outbreak, Kenya, 2004. Environ Health Perspect.
2005;113(12):1779–83.
18. Kumar P, Mahato DK, Kamle M, Mohanta TK, Kang SG. Aflatoxins: a global concern for food
safety, human health and their management. Front Microbiol. 2017;7:2170.
19. Josse R, Dumont J, Fautrel A, Robin M-A, Guillouzo A. Identification of early target genes
of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other
genotoxic compounds. Toxicol Appl Pharmacol. 2012;258(2):176–87.
20. Bondy SC, Naderi S. Contribution of hepatic cytochrome P450 systems to the generation of
reactive oxygen species. Biochem Pharmacol. 1994;48(1):155–9.
21. Kodama M, Inoue F, Akao M. Enzymatic and non-enzymatic formation of free radicals from
aflatoxin B1. Free Radic Res Commun. 1990;10(3):137–42.
22. Qian G, Tang L, Guo X, Wang F, Massey ME, Su J, et al. Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats. J Appl
Toxicol. 2014;34(3):241–9.
23. Mehrzad J, Devriendt B, Baert K, Cox E. Aflatoxin B1 interferes with the antigen-presenting
capacity of porcine dendritic cells. Toxicol In Vitro. 2014;28(4):531–7.
24. Shen HM, Shi CY, Shen Y, Ong CN. Detection of elevated reactive oxygen species level in
cultured rat hepatocytes treated with aflatoxin B1. Free Radic Biol Med. 1996;21(2):139–46.
25. Yilmaz S, Kaya E, Kisacam MA. The effect on oxidative stress of aflatoxin and protective
effect of lycopene on aflatoxin damage. In: Aflatoxin-control, analysis, detection and health
risks. London: IntechOpen; 2017. p. 67–90.
26. Lu X, Hu B, Shao L, Tian Y, Jin T, Jin Y, et al. Integrated analysis of transcriptomics and
metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat. Food Chem Toxicol.
2013;55:444–55.
27. Rotimi OA, Rotimi SO, Duru CU, Ebebeinwe OJ, Abiodun AO, Oyeniyi BO, et al. Acute
aflatoxin B1 - induced hepatotoxicity alters gene expression and disrupts lipid and lipoprotein
metabolism in rats. Toxicol Rep. 2017;4:408–14.
28. Shen HM, Ong CN. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res. 1996;366(1):23–44.
29. Sun X, Ai M, Wang Y, Shen S, Gu Y, Jin Y, et al. Selective induction of tumor cell apoptosis
by a novel P450-mediated reactive oxygen species (ROS) inducer methyl 3-(4-nitrophenyl)
propiolate. J Biol Chem. 2013;288(13):8826–37.
30. Hendrickse R. Of sick turkeys, kwashiorkor, malaria, perinatal mortality, heroin addicts and
food poisoning: research on the influence of aflatoxins on child health in the tropics. Ann Trop
Med Parasitol. 1997;91(7):787–93.
31. Rogers GW, Nadanaciva S, Swiss R, Divakaruni AS, Will Y. Assessment of fatty acid beta
oxidation in cells and isolated mitochondria. Curr Protoc Toxicol. 2014;60:31–9.
32. Tsai F-J, Chen S-Y, Liu Y-C, Liao H-Y, Chen C-J. The comparison of CHCA solvent compositions for improving LC-MALDI performance and its application to study the impact of aflatoxin
B1 on the liver proteome of diabetes mellitus type 1 mice. PLoS One. 2017;12(7):e0181423.
33. Mauro A, Garcia-Cela E, Pietri A, Cotty PJ, Battilani P. Biological control products for aflatoxin prevention in Italy: commercial field evaluation of atoxigenic Aspergillus flavus active
ingredients. Toxins. 2018;10(1):30.
34. Davies B. Drying survey in Kenya: North Rift--AflaSTOP: storage and drying for aflatoxin
prevention. Gates Open Res. 2019;3:1–36.
35. Negash D. A review of aflatoxin: occurrence, prevention, and gaps in both food and feed
safety. J Nutr Health Food Eng. 2018;8:190–7.
36. Bandyopadhyay R, Kumar M, Leslie JF. Relative severity of aflatoxin contamination of cereal
crops in West Africa. Food Addit Contam. 2007;24(10):1109–14.
37. Phillips TD, Afriyie-Gyawu E, Williams J, Huebner H, Ankrah NA, Ofori-Adjei D, et al.
Reducing human exposure to aflatoxin through the use of clay: a review. Food Addit Contam
Part A Chem Anal Control Expo Risk Assess. 2008;25(2):134–45.
S. Sabir et al.