339
41. Chavan H, Krishnamurthy P. Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon
receptor (AhR). J Biol Chem. 2012;287(38):32054–68.
42. Dragin N, Shi Z, Madan R, Karp CL, Sartor MA, Chen C, et al. Phenotype of the Cyp1a1/1a2/1b1
(-/-) triple-knockout mouse. Mol Pharmacol. 2008;73(6):1844–56.
43. Jiang W, Wang L, Zhang W, Coffee R, Fazili IS, Moorthy B. Persistent induction of cytochrome P450 (CYP) 1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by
sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res
Commun. 2009;390(4):1419–24.
44. Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, et al. Disruption of
the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation
of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther.
2010;335(2):369–79.
45. Kondraganti SR, Fernandez-Salguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy
B. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling
and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation
in vivo. Int J Cancer. 2003;103(1):5–11.
46. Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, et al. Arylhydrocarbon
receptor- dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by
polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered
C57BL/6J mice. Carcinogenesis. 2002;23(7):1199–207.
47. Guengerich FP. Cytochrome p450 and chemical toxicology. Chem Res Toxicol.
2007;21(1):70–83.
48. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor- mediated
induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem.
2004;279(23):23847–50.
49. Ioannides C. Cytochromes P450: role in the metabolism and toxicity of drugs and other xenobiotics. Cambridge: Royal Society of Chemistry; 2008.
50. Walsh AA, Szklarz GD, Scott EE. Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J Biol Chem. 2013;288(18):12932–43.
51. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, et al. Structure−
function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4
by 33 flavonoid derivatives. Chem Res Toxicol. 2010;23(12):1921–35.
52. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K. Metabolic activation of polycyclic
aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1
allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Drug Metab Dispos. 2001;29(9):1176–82.
53. Choudhary D, Jansson I, Schenkman J, Sarfarazi M, Stoilov I. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem
Biophys. 2003;414(1):91–100.
54. Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, et al. Disruption of
the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J
Pharmacol Exp Ther. 2004;310(2):512–9.
55. Fazili IS, Jiang W, Wang L, Felix EA, Khatlani T, Coumoul X, et al. Persistent induction
of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence
for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther.
2010;333(1):99–109.
56. Moorthy B. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in
rat hepatic and extrahepatic tissues. J Pharmacol Exp Ther. 2000;294(1):313–22.
19 Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders
41. Chavan H, Krishnamurthy P. Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon
receptor (AhR). J Biol Chem. 2012;287(38):32054–68.
42. Dragin N, Shi Z, Madan R, Karp CL, Sartor MA, Chen C, et al. Phenotype of the Cyp1a1/1a2/1b1
(-/-) triple-knockout mouse. Mol Pharmacol. 2008;73(6):1844–56.
43. Jiang W, Wang L, Zhang W, Coffee R, Fazili IS, Moorthy B. Persistent induction of cytochrome P450 (CYP) 1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by
sustained transcriptional activation of the corresponding promoters. Biochem Biophys Res
Commun. 2009;390(4):1419–24.
44. Jiang W, Wang L, Kondraganti SR, Fazili IS, Couroucli XI, Felix EA, et al. Disruption of
the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation
of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. J Pharmacol Exp Ther.
2010;335(2):369–79.
45. Kondraganti SR, Fernandez-Salguero P, Gonzalez FJ, Ramos KS, Jiang W, Moorthy
B. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling
and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation
in vivo. Int J Cancer. 2003;103(1):5–11.
46. Shimada T, Inoue K, Suzuki Y, Kawai T, Azuma E, Nakajima T, et al. Arylhydrocarbon
receptor- dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by
polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered
C57BL/6J mice. Carcinogenesis. 2002;23(7):1199–207.
47. Guengerich FP. Cytochrome p450 and chemical toxicology. Chem Res Toxicol.
2007;21(1):70–83.
48. Nebert DW, Dalton TP, Okey AB, Gonzalez FJ. Role of aryl hydrocarbon receptor- mediated
induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem.
2004;279(23):23847–50.
49. Ioannides C. Cytochromes P450: role in the metabolism and toxicity of drugs and other xenobiotics. Cambridge: Royal Society of Chemistry; 2008.
50. Walsh AA, Szklarz GD, Scott EE. Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism. J Biol Chem. 2013;288(18):12932–43.
51. Shimada T, Tanaka K, Takenaka S, Murayama N, Martin MV, Foroozesh MK, et al. Structure−
function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4
by 33 flavonoid derivatives. Chem Res Toxicol. 2010;23(12):1921–35.
52. Shimada T, Oda Y, Gillam EM, Guengerich FP, Inoue K. Metabolic activation of polycyclic
aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1
allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009.
Drug Metab Dispos. 2001;29(9):1176–82.
53. Choudhary D, Jansson I, Schenkman J, Sarfarazi M, Stoilov I. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem
Biophys. 2003;414(1):91–100.
54. Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, et al. Disruption of
the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury. J
Pharmacol Exp Ther. 2004;310(2):512–9.
55. Fazili IS, Jiang W, Wang L, Felix EA, Khatlani T, Coumoul X, et al. Persistent induction
of cytochrome P4501A1 in human hepatoma cells by 3-methylcholanthrene: evidence
for sustained transcriptional activation of the CYP1A1 promoter. J Pharmacol Exp Ther.
2010;333(1):99–109.
56. Moorthy B. Persistent expression of 3-methylcholanthrene-inducible cytochromes P4501A in
rat hepatic and extrahepatic tissues. J Pharmacol Exp Ther. 2000;294(1):313–22.
19 Role of Polycyclic Aromatic Hydrocarbons as EDCs in Metabolic Disorders