202
expression in rat liver produced by the cholangiocarcinogenic agent furan. Toxicol Pathol.
2010;38(2):230–43.
86. Morehouse KM, Nyman PJ, McNeal TP, DiNovi MJ, Perfetti GA. Survey of furan in heat
processed foods by headspace gas chromatography/mass spectrometry and estimated adult
exposure. Food Addit Contam. 2008;25(3):259–64.
87. Uçar S, Pandir D. Furan induced ovarian damage in non-diabetic and diabetic rats and cellular protective role of lycopene. Arch Gynecol Obstet. 2017;296(5):1027–37.
88. Saracoğlu G, Baş H, Pandır D. Furan-induced cardiotoxicity in diabetic rats and protective
role of lycopene. J Food Biochem. 2019;43(3):e12738.
89. Aldahmash BA, El-Nagar DM, Ibrahim KE. Attenuation of hepatotoxicity and oxidative
stress in diabetes STZ-induced type 1 by biotin in Swiss albino mice. Saudi J Biol Sci.
2016;23(2):311–7.
90. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem.
2006;97(6):1634–58.
91. Perry G, Cash AD, Smith MA. Alzheimer disease and oxidative stress. Biomed Res Int.
2002;2(3):120–3.
92. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in
diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005;4(1):5.
93. Novo E, Parola M. Redox mechanisms in hepatic chronic wound healing and fibrogenesis.
Fibrogenesis Tissue Repair. 2008;1(1):5.
94. Diplock A, Charuleux J-L, Crozier-Willi G, Kok F, Rice-Evans C, Roberfroid M, et al.
Functional food science and defence against reactive oxidative species. Br J Nutr.
1998;80(S1):S77–S112.
95. Cutler RG. Oxidative stress profiling: part I. Its potential importance in the optimization of
human health. Ann N Y Acad Sci. 2005;1055(1):93–135.
96. Sureda F, Junyent F, Verdaguer E, Auladell C, Pelegri C, Vilaplana J, et al. Antiapoptotic
drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Curr Pharm
Des. 2011;17(3):230–45.
97. Spiteller G. Is lipid peroxidation of polyunsaturated acids the only source of free radicals that
induce aging and age-related diseases? Rejuvenation Res. 2010;13(1):91–103.
98. Choi H-D, Seo P-J, Son B-W, Kang BW. Synthesis of 2-(4-hydroxyphenyl) benzofurans and
their application to β-amyloid aggregation inhibitor. Arch Pharm Res. 2004;27(1):19.
99. Lee E-S, Park BC, Paek S-H, Lee Y-S, Basnet A, Jin D-Q, et al. Potent analgesic and antiinflammatory activities of 1-furan-2-yl-3-pyridin-2-yl-propenone with gastric ulcer sparing
effect. Biol Pharm Bull. 2006;29(2):361–4.
100. Pentreath VW, Slamon ND. Astrocyte phenotype and prevention against oxidative damage in
neurotoxicity. Hum Exp Toxicol. 2000;19(11):641–9.. Epub 2001/02/24
101. Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest. 2005;115(3):485–91.
102. Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, et al. Serotonin regulates
pancreatic beta cell mass during pregnancy. Nat Med. 2010;16(7):804.
103. Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW, et al. The furan fatty acid metabolite
CMPF is elevated in diabetes and induces β cell dysfunction. Cell Metab. 2014;19(4):653–66.
104. Fan X, Huang L, Sokorai KJ. Factors affecting thermally induced furan formation. J Agric
Food Chem. 2008;56(20):9490–4. Epub 2008/09/25.
105. Becalski A, Seaman S. Furan precursors in food: a model study and development of a simple headspace method for determination of furan. J AOAC Int. 2005;88(1):102–6. Epub
2005/03/12.
106. Quarta B, Anese M. Furfurals removal from roasted coffee powder by vacuum treatment.
Food Chem. 2012;130(3):610–4.
107. Anese M, Manzocco L, Calligaris S, Nicoli MC. Industrially applicable strategies for
mitigating acrylamide, furan, and 5-hydroxymethylfurfural in food. J Agric Food Chem.
2013;61(43):10209–14.
S. Muzammil et al.
expression in rat liver produced by the cholangiocarcinogenic agent furan. Toxicol Pathol.
2010;38(2):230–43.
86. Morehouse KM, Nyman PJ, McNeal TP, DiNovi MJ, Perfetti GA. Survey of furan in heat
processed foods by headspace gas chromatography/mass spectrometry and estimated adult
exposure. Food Addit Contam. 2008;25(3):259–64.
87. Uçar S, Pandir D. Furan induced ovarian damage in non-diabetic and diabetic rats and cellular protective role of lycopene. Arch Gynecol Obstet. 2017;296(5):1027–37.
88. Saracoğlu G, Baş H, Pandır D. Furan-induced cardiotoxicity in diabetic rats and protective
role of lycopene. J Food Biochem. 2019;43(3):e12738.
89. Aldahmash BA, El-Nagar DM, Ibrahim KE. Attenuation of hepatotoxicity and oxidative
stress in diabetes STZ-induced type 1 by biotin in Swiss albino mice. Saudi J Biol Sci.
2016;23(2):311–7.
90. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem.
2006;97(6):1634–58.
91. Perry G, Cash AD, Smith MA. Alzheimer disease and oxidative stress. Biomed Res Int.
2002;2(3):120–3.
92. Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress and the use of antioxidants in
diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005;4(1):5.
93. Novo E, Parola M. Redox mechanisms in hepatic chronic wound healing and fibrogenesis.
Fibrogenesis Tissue Repair. 2008;1(1):5.
94. Diplock A, Charuleux J-L, Crozier-Willi G, Kok F, Rice-Evans C, Roberfroid M, et al.
Functional food science and defence against reactive oxidative species. Br J Nutr.
1998;80(S1):S77–S112.
95. Cutler RG. Oxidative stress profiling: part I. Its potential importance in the optimization of
human health. Ann N Y Acad Sci. 2005;1055(1):93–135.
96. Sureda F, Junyent F, Verdaguer E, Auladell C, Pelegri C, Vilaplana J, et al. Antiapoptotic
drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Curr Pharm
Des. 2011;17(3):230–45.
97. Spiteller G. Is lipid peroxidation of polyunsaturated acids the only source of free radicals that
induce aging and age-related diseases? Rejuvenation Res. 2010;13(1):91–103.
98. Choi H-D, Seo P-J, Son B-W, Kang BW. Synthesis of 2-(4-hydroxyphenyl) benzofurans and
their application to β-amyloid aggregation inhibitor. Arch Pharm Res. 2004;27(1):19.
99. Lee E-S, Park BC, Paek S-H, Lee Y-S, Basnet A, Jin D-Q, et al. Potent analgesic and antiinflammatory activities of 1-furan-2-yl-3-pyridin-2-yl-propenone with gastric ulcer sparing
effect. Biol Pharm Bull. 2006;29(2):361–4.
100. Pentreath VW, Slamon ND. Astrocyte phenotype and prevention against oxidative damage in
neurotoxicity. Hum Exp Toxicol. 2000;19(11):641–9.. Epub 2001/02/24
101. Buchanan TA, Xiang AH. Gestational diabetes mellitus. J Clin Invest. 2005;115(3):485–91.
102. Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, et al. Serotonin regulates
pancreatic beta cell mass during pregnancy. Nat Med. 2010;16(7):804.
103. Prentice KJ, Luu L, Allister EM, Liu Y, Jun LS, Sloop KW, et al. The furan fatty acid metabolite
CMPF is elevated in diabetes and induces β cell dysfunction. Cell Metab. 2014;19(4):653–66.
104. Fan X, Huang L, Sokorai KJ. Factors affecting thermally induced furan formation. J Agric
Food Chem. 2008;56(20):9490–4. Epub 2008/09/25.
105. Becalski A, Seaman S. Furan precursors in food: a model study and development of a simple headspace method for determination of furan. J AOAC Int. 2005;88(1):102–6. Epub
2005/03/12.
106. Quarta B, Anese M. Furfurals removal from roasted coffee powder by vacuum treatment.
Food Chem. 2012;130(3):610–4.
107. Anese M, Manzocco L, Calligaris S, Nicoli MC. Industrially applicable strategies for
mitigating acrylamide, furan, and 5-hydroxymethylfurfural in food. J Agric Food Chem.
2013;61(43):10209–14.
S. Muzammil et al.