157
Projects to Reduce Exposures to EDCs
Humans and animals are continuously exposed to numerous EDCs of different
chemical and physical properties. These chemicals are even present in trace amounts
in our environment. By assessing the EDCs, the exposure to them can be minimized
and thereby multiple metabolic disorders can be avoided effectively. The health
authorities must create projects and coordinated efforts immediately to safeguard
human health from the harmful exposure of EDCs [10].
Conclusion
Endocrine disrupting chemicals are steadily increasing in our environment. The
children are in a vulnerable position due to continuous exposure to EDCs through
toys, feeding bottles, baby care products, and food. Because of the obesogenic
nature of EDCs, these chemicals are capable of inducing extensive adipogenesis in
children through diverse mechanisms resulting in pediatric obesity. Although a
strong association exists between EDCs and childhood obesity, there is a scarcity of
data. No proper documentation is available regarding the relationship between rate
of exposure to EDCs and level of toxicities in humans. Furthermore, specialized
investigations are still required to be conducted in humans to better understand the
effect of EDCs in obesity. With the rapid rise in childhood obesity rate owing to
EDCs, rigorous efforts are promptly required to safeguard our future generations
from this menace.
Conflict of Interest The authors declare that there is no conflict of interest.
References
1. Gore AC, Chappell V, Fenton S, Flaws JA, Nadal A, Prins GS, et al. EDC-2: the Endocrine
Society's second scientific statement on endocrine-disrupting chemicals. Endocr Rev.
2015;36(6):E1–E150.
2. Colborn T, Vom Saal F, Soto A. Developmental effects of endocrine-disrupting chemicals in
wildlife and humans. Environ Health Perspect. 1993;101:378–84.
3. Bergman Å, Heindel JJ, Kasten T, Kidd KA, Jobling S, Neira M, et al. The impact of endocrine
disruption: a consensus statement on the state of the science. Morrisville: National Institute of
Environmental Health Sciences; 2013.
4. Diamanti-Kandarakis E, Bourguignon J-P, Giudice LC, Hauser R, Prins GS, Soto AM, et al.
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev.
2009;30(4):293–342.
5. Caliman FA, Gavrilescu M. Pharmaceuticals, personal care products and endocrine disrupting
agents in the environment—a review. CLEAN–Soil Air Water. 2009;37(4-5):277–303.
6. Rhomberg LR, Goodman JE. Low-dose effects and nonmonotonic dose–responses of endocrine
disrupting chemicals: Has the case been made? Regul Toxicol Pharmacol. 2012;64(1):130–3.
10 Endocrine Disrupting Chemicals Induced Childhood Obesity
Projects to Reduce Exposures to EDCs
Humans and animals are continuously exposed to numerous EDCs of different
chemical and physical properties. These chemicals are even present in trace amounts
in our environment. By assessing the EDCs, the exposure to them can be minimized
and thereby multiple metabolic disorders can be avoided effectively. The health
authorities must create projects and coordinated efforts immediately to safeguard
human health from the harmful exposure of EDCs [10].
Conclusion
Endocrine disrupting chemicals are steadily increasing in our environment. The
children are in a vulnerable position due to continuous exposure to EDCs through
toys, feeding bottles, baby care products, and food. Because of the obesogenic
nature of EDCs, these chemicals are capable of inducing extensive adipogenesis in
children through diverse mechanisms resulting in pediatric obesity. Although a
strong association exists between EDCs and childhood obesity, there is a scarcity of
data. No proper documentation is available regarding the relationship between rate
of exposure to EDCs and level of toxicities in humans. Furthermore, specialized
investigations are still required to be conducted in humans to better understand the
effect of EDCs in obesity. With the rapid rise in childhood obesity rate owing to
EDCs, rigorous efforts are promptly required to safeguard our future generations
from this menace.
Conflict of Interest The authors declare that there is no conflict of interest.
References
1. Gore AC, Chappell V, Fenton S, Flaws JA, Nadal A, Prins GS, et al. EDC-2: the Endocrine
Society's second scientific statement on endocrine-disrupting chemicals. Endocr Rev.
2015;36(6):E1–E150.
2. Colborn T, Vom Saal F, Soto A. Developmental effects of endocrine-disrupting chemicals in
wildlife and humans. Environ Health Perspect. 1993;101:378–84.
3. Bergman Å, Heindel JJ, Kasten T, Kidd KA, Jobling S, Neira M, et al. The impact of endocrine
disruption: a consensus statement on the state of the science. Morrisville: National Institute of
Environmental Health Sciences; 2013.
4. Diamanti-Kandarakis E, Bourguignon J-P, Giudice LC, Hauser R, Prins GS, Soto AM, et al.
Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev.
2009;30(4):293–342.
5. Caliman FA, Gavrilescu M. Pharmaceuticals, personal care products and endocrine disrupting
agents in the environment—a review. CLEAN–Soil Air Water. 2009;37(4-5):277–303.
6. Rhomberg LR, Goodman JE. Low-dose effects and nonmonotonic dose–responses of endocrine
disrupting chemicals: Has the case been made? Regul Toxicol Pharmacol. 2012;64(1):130–3.
10 Endocrine Disrupting Chemicals Induced Childhood Obesity