83
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_5
Chapter 5
Impaired Lipid Metabolism in Metabolic
Disorders
Kamran Haider, Kanwal Rehman, and Muhammad Sajid Hamid Akash
Abstract Metabolic disorders relating to impaired lipid metabolism have become
an annoying issue in current era. Energy dense diet coupled with sedentary life-style
are crucial triggering events for these metabolic disorders that significantly disturb
various metabolic pathways notably carbohydrate and lipid homeostasis. The ultimately developed metabolic syndromes such as lactic acidosis, obesity, nonalcoholic fatty liver disease, type 2 diabetes, polycystic ovaries, and neurodegenerative
disorders are potential health risks that disturb the quality of life. Deposition of
lipids in the non-adipose tissues such as muscle and liver is also strongly interlinked
with insulin resistance. Ultimately, loss of particular function and differentiation of
β-cells is caused by progressive fat deposition in the pancreas leading to reduction
in insulin secretion. So, strategies to prevent, compete, and overcome these metabolic disturbances are radical therapeutic and nutritional interventions, mainly
involving life-style management and weight reduction. The ultimate approaches
anticipate defensive role in abating or minimizing these undesirable consequences
and improve quality of life.
Keywords Bioactive lipids · Insulin resistance · Metabolic syndrome · Lipid
homeostasis
K. Haider · K. Rehman, PhD (*)
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
M. S. H. Akash, PhD
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan
© The Editor(s) (if applicable) and The Author(s), under exclusive license
to Springer Nature Switzerland AG 2021
M. S. H. Akash et al. (eds.), Endocrine Disrupting Chemicals-induced
Metabolic Disorders and Treatment Strategies, Emerging Contaminants
and Associated Treatment Technologies,
https://doi.org/10.1007/978-3-030-45923-9_5
Chapter 5
Impaired Lipid Metabolism in Metabolic
Disorders
Kamran Haider, Kanwal Rehman, and Muhammad Sajid Hamid Akash
Abstract Metabolic disorders relating to impaired lipid metabolism have become
an annoying issue in current era. Energy dense diet coupled with sedentary life-style
are crucial triggering events for these metabolic disorders that significantly disturb
various metabolic pathways notably carbohydrate and lipid homeostasis. The ultimately developed metabolic syndromes such as lactic acidosis, obesity, nonalcoholic fatty liver disease, type 2 diabetes, polycystic ovaries, and neurodegenerative
disorders are potential health risks that disturb the quality of life. Deposition of
lipids in the non-adipose tissues such as muscle and liver is also strongly interlinked
with insulin resistance. Ultimately, loss of particular function and differentiation of
β-cells is caused by progressive fat deposition in the pancreas leading to reduction
in insulin secretion. So, strategies to prevent, compete, and overcome these metabolic disturbances are radical therapeutic and nutritional interventions, mainly
involving life-style management and weight reduction. The ultimate approaches
anticipate defensive role in abating or minimizing these undesirable consequences
and improve quality of life.
Keywords Bioactive lipids · Insulin resistance · Metabolic syndrome · Lipid
homeostasis
K. Haider · K. Rehman, PhD (*)
Department of Pharmacy, University of Agriculture Faisalabad, Faisalabad, Pakistan
M. S. H. Akash, PhD
Department of Pharmaceutical Chemistry, Government College University Faisalabad,
Faisalabad, Pakistan