lined by interacting amino acids as predicted from the ligplot. In in vitro experiments, the molecule emerged to be active against the cell line used in inhibiting the
cell growth (Paarakh et al. 2015).
22.26 Conclusion
Piperine is a versatile chemical entity and it possesses different anticancer properties
as well it has the capability to enhance the bioavailability of important drugs either
in its form or in a modified dosage form. Further activity is required to understand
its utility in other important metabolic pathways.
Fig. 22.13 The seizure frequency (A) and latency to first seizure (B) of Kunming mice within
30 min after inducing acute seizure by PTZ (80 mg/kg, i.p.) in absence or presence of oral
administration of unformulated piperine at 15 mg/kg or piperine nanoparticles at 7.5 or 15 mg/kg
45 min before PTZ injection. Each point represents mean ± S.D (n = 6, *p < 0.05, **p < 0.01
compared with PTZ group). With copyright permission (Ren et al. 2019a)
22 Piperine: Sources, Properties, Applications …
783
cell growth (Paarakh et al. 2015).
22.26 Conclusion
Piperine is a versatile chemical entity and it possesses different anticancer properties
as well it has the capability to enhance the bioavailability of important drugs either
in its form or in a modified dosage form. Further activity is required to understand
its utility in other important metabolic pathways.
Fig. 22.13 The seizure frequency (A) and latency to first seizure (B) of Kunming mice within
30 min after inducing acute seizure by PTZ (80 mg/kg, i.p.) in absence or presence of oral
administration of unformulated piperine at 15 mg/kg or piperine nanoparticles at 7.5 or 15 mg/kg
45 min before PTZ injection. Each point represents mean ± S.D (n = 6, *p < 0.05, **p < 0.01
compared with PTZ group). With copyright permission (Ren et al. 2019a)
22 Piperine: Sources, Properties, Applications …
783