and hydrophobic drugs within their layers which make them unique carrier for drug
delivery. In spite of their advantages, successful delivery of liposomes through oral
route has always been a challenge as the question remains whether they would
remain stable along the GI tract conditions (Park et al. 2011). However, the
effective delivery of phytochemicals through oral route has been demonstrated in
animal models (Yi et al. 2013). Flammulina velutipes sterols was orally delivered
through liposomes in Kunming mice and relative bioavailability of ergosterol and
22,23- dihydroergosterol at 162.9 and 244.2%, respectively, was obtained. The
sterols, however, was rapidly eliminated within 4 h. A faster and better absorption
Fig. 20.3 Major difference between liposome and phytosome
® (Reproduced with permission
from Selmaty et al. 2010, Copyright © Elsevier Science BV 2009)
20 Encapsulation of Bioactive Compound and Its Therapeutic Potential
699
delivery. In spite of their advantages, successful delivery of liposomes through oral
route has always been a challenge as the question remains whether they would
remain stable along the GI tract conditions (Park et al. 2011). However, the
effective delivery of phytochemicals through oral route has been demonstrated in
animal models (Yi et al. 2013). Flammulina velutipes sterols was orally delivered
through liposomes in Kunming mice and relative bioavailability of ergosterol and
22,23- dihydroergosterol at 162.9 and 244.2%, respectively, was obtained. The
sterols, however, was rapidly eliminated within 4 h. A faster and better absorption
Fig. 20.3 Major difference between liposome and phytosome
® (Reproduced with permission
from Selmaty et al. 2010, Copyright © Elsevier Science BV 2009)
20 Encapsulation of Bioactive Compound and Its Therapeutic Potential
699