Chapter 20
Encapsulation of Bioactive Compound
and Its Therapeutic Potential
Lalduhsanga Pachuau, Laldinchhana, Probin Kumar Roy,
James H. Zothantluanga, Supratim Ray, and Sanjib Das
Abstract Micro- or nanoencapsulation has become one of the most attractive
approaches to enhance the stability and bioavailability of bioactive compounds
isolated from natural products. In addition, such encapsulation also provides an
opportunity to modulate the release of bioactive compounds by using functional
polymers that can be fine-tuned according to the need of the body. Over the last
10 years, increasing research works have been dedicated toward the encapsulation
of bioactive compounds for various purposes. Numerous techniques, embracing
micro- and nanoplatforms including spray drying, freeze drying, micro- and multiple emulsification, electrospinning, and coacervation, have been utilized to
achieve the encapsulations. Such encapsulations have been found to improve the
physicochemical properties of the bioactive compound, provide stability and
enhanced bioavailability, controlled release of the compound, enhancing bioactivity, and masking of flavor or taste, along with several other benefits. Wide ranges of
materials including lipids, synthetic, and natural polymers have been utilized, and
the type and amount of the wall formers have been found to influence the performance and functionality of these preparations.
Keywords Encapsulation Á Bioavailability Á Bioactive compounds Á Hydrogels Á
Electrodynamic processes
L. Pachuau (&) Á S. Ray Á S. Das
Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India
e-mail: aduhapc@gmail.com
Laldinchhana Á P. K. Roy
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences,
Aizawl 796017, India
J. H. Zothantluanga
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, India
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_20
687
Encapsulation of Bioactive Compound
and Its Therapeutic Potential
Lalduhsanga Pachuau, Laldinchhana, Probin Kumar Roy,
James H. Zothantluanga, Supratim Ray, and Sanjib Das
Abstract Micro- or nanoencapsulation has become one of the most attractive
approaches to enhance the stability and bioavailability of bioactive compounds
isolated from natural products. In addition, such encapsulation also provides an
opportunity to modulate the release of bioactive compounds by using functional
polymers that can be fine-tuned according to the need of the body. Over the last
10 years, increasing research works have been dedicated toward the encapsulation
of bioactive compounds for various purposes. Numerous techniques, embracing
micro- and nanoplatforms including spray drying, freeze drying, micro- and multiple emulsification, electrospinning, and coacervation, have been utilized to
achieve the encapsulations. Such encapsulations have been found to improve the
physicochemical properties of the bioactive compound, provide stability and
enhanced bioavailability, controlled release of the compound, enhancing bioactivity, and masking of flavor or taste, along with several other benefits. Wide ranges of
materials including lipids, synthetic, and natural polymers have been utilized, and
the type and amount of the wall formers have been found to influence the performance and functionality of these preparations.
Keywords Encapsulation Á Bioavailability Á Bioactive compounds Á Hydrogels Á
Electrodynamic processes
L. Pachuau (&) Á S. Ray Á S. Das
Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India
e-mail: aduhapc@gmail.com
Laldinchhana Á P. K. Roy
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences,
Aizawl 796017, India
J. H. Zothantluanga
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, India
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
D. Pal and A. K. Nayak (eds.), Bioactive Natural Products
for Pharmaceutical Applications, Advanced Structured Materials 140,
https://doi.org/10.1007/978-3-030-54027-2_20
687