Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH,
Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG (2011) Development of
Neh2-luciferase reporter and its application for high throughput screening and real-time
monitoring of Nrf2 activators. Chem Biol 18(6):752–765. https://doi.org/10.1016/j.chembiol.
2011.03.013
Stoveken HM, Larsen SD, Smrcka AV, Tall GG (2018) Gedunin- and Khivorin-derivatives are
small-molecule partial agonists for adhesion G protein-coupled receptors GPR56/ADGRG1
and GPR114/ADGRG5. Mol Pharmacol 93(5):477–488. https://doi.org/10.1124/mol.117.
111476
Subapriya R, Nagini S (2005) Medicinal properties of neem leaves: a review. Curr Med Chem
Anticancer Agents 5(2):149–146. https://doi.org/10.2174/1568011053174828
Subramani R, Gonzalez E, Nandy SB, Arumugam A, Camacho F, Medel J, Alabi D,
Lakshmanaswamy R (2017) Gedunin inhibits pancreatic cancer by altering sonic hedgehog
signaling pathway. Oncotarget 8(7):10891–10904. https://doi.org/10.18632/oncotarget.8055
Tanagala KKK, Baba AB, Kowshik J, Reddy GB, Nagini S (2018) Gedunin, a neem limonoid in
combination with epalrestat inhibits cancer hallmarks by attenuating aldose reductase-driven
oncogenic signaling in SCC131 oral cancer cells. Anticancer Agents Med Chem 18(14):2042–
2052. https://doi.org/10.2174/1871520618666180731093433
Thoenen H (1991) The changing scene of neurotrophic factors. Trends Neurosci 14(5):165–170.
https://doi.org/10.1016/0166-2236(91)90097-e
Tom S, Rane A, Katewa AS, Chamoli M, Matsumoto RR, Andersen JK, Chinta SJ (2019)
Gedunin inhibits oligomeric abeta1-42-induced microglia activation via modulation of
Nrf2-NF-kappaB signaling. Mol Neurobiol 56(11):7851–7862. https://doi.org/10.1007/
s12035-019-1636-9
Uddin SJ, Nahar L, Shilpi JA, Shoeb M, Borkowski T, Gibbons S, Middleton M, Byres M,
Sarker SD (2007) Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of
CaCo 2 colon cancer cell line in vitro. Phytotherapy Res PTR 21(8):757–761. https://doi.org/10.
1002/ptr.2159
Uko O, Edafiogho I, Ataja A (1995) Possible laxative acivity of azadirachta indica (neem). West
African J Pharmacol Drug Res 11(1)
Vinson-Hieronymus H, Golub TR, Lamb J, Stegmaier K (2011) Celastrol, gedunin, and
derivatives thereof as HSP90 inhibitors. Google Patents
Yang W, Xie J, Qiang Q, Li L, Lin X, Ren Y, Ren W, Liu Q, Zhou G, Wei W, Saiyin H, Ma L
(2019) Gedunin degrades aggregates of mutant huntingtin protein and intranuclear inclusions
via the proteasomal pathway in neurons and fibroblasts from patients with huntington’s
disease. Neurosci Bulletin 35(6):1024–1034. https://doi.org/10.1007/s12264-019-00421-5
Yerbanga RS, Lucantoni L, Ouédraogo RK, Da DF, Yao FA, Yaméogo KB, Churcher TS,
Lupidi G, Taglialatela-Scafati O, Gouagna LC, Cohuet A, Christophides GK, Ouédraogo JB,
Habluetzel A (2014) Transmission blocking activity of Azadirachta indica and Guiera
senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates
in Anopheles coluzzii mosquitoes. Parasites Vect 7(1):185. https://doi.org/10.1186/1756-33057-185
Zhang B, Au Q, Yoon IS, Tremblay MH, Yip G, Zhou Y, Barber JR, Ng SC (2009) Identification
of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress
induced injury. Biochem Biophys Res Commun 390(3):925–930. https://doi.org/10.1016/j.
bbrc.2009.10.079
586
Y. S. Ong et al.
Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG (2011) Development of
Neh2-luciferase reporter and its application for high throughput screening and real-time
monitoring of Nrf2 activators. Chem Biol 18(6):752–765. https://doi.org/10.1016/j.chembiol.
2011.03.013
Stoveken HM, Larsen SD, Smrcka AV, Tall GG (2018) Gedunin- and Khivorin-derivatives are
small-molecule partial agonists for adhesion G protein-coupled receptors GPR56/ADGRG1
and GPR114/ADGRG5. Mol Pharmacol 93(5):477–488. https://doi.org/10.1124/mol.117.
111476
Subapriya R, Nagini S (2005) Medicinal properties of neem leaves: a review. Curr Med Chem
Anticancer Agents 5(2):149–146. https://doi.org/10.2174/1568011053174828
Subramani R, Gonzalez E, Nandy SB, Arumugam A, Camacho F, Medel J, Alabi D,
Lakshmanaswamy R (2017) Gedunin inhibits pancreatic cancer by altering sonic hedgehog
signaling pathway. Oncotarget 8(7):10891–10904. https://doi.org/10.18632/oncotarget.8055
Tanagala KKK, Baba AB, Kowshik J, Reddy GB, Nagini S (2018) Gedunin, a neem limonoid in
combination with epalrestat inhibits cancer hallmarks by attenuating aldose reductase-driven
oncogenic signaling in SCC131 oral cancer cells. Anticancer Agents Med Chem 18(14):2042–
2052. https://doi.org/10.2174/1871520618666180731093433
Thoenen H (1991) The changing scene of neurotrophic factors. Trends Neurosci 14(5):165–170.
https://doi.org/10.1016/0166-2236(91)90097-e
Tom S, Rane A, Katewa AS, Chamoli M, Matsumoto RR, Andersen JK, Chinta SJ (2019)
Gedunin inhibits oligomeric abeta1-42-induced microglia activation via modulation of
Nrf2-NF-kappaB signaling. Mol Neurobiol 56(11):7851–7862. https://doi.org/10.1007/
s12035-019-1636-9
Uddin SJ, Nahar L, Shilpi JA, Shoeb M, Borkowski T, Gibbons S, Middleton M, Byres M,
Sarker SD (2007) Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of
CaCo 2 colon cancer cell line in vitro. Phytotherapy Res PTR 21(8):757–761. https://doi.org/10.
1002/ptr.2159
Uko O, Edafiogho I, Ataja A (1995) Possible laxative acivity of azadirachta indica (neem). West
African J Pharmacol Drug Res 11(1)
Vinson-Hieronymus H, Golub TR, Lamb J, Stegmaier K (2011) Celastrol, gedunin, and
derivatives thereof as HSP90 inhibitors. Google Patents
Yang W, Xie J, Qiang Q, Li L, Lin X, Ren Y, Ren W, Liu Q, Zhou G, Wei W, Saiyin H, Ma L
(2019) Gedunin degrades aggregates of mutant huntingtin protein and intranuclear inclusions
via the proteasomal pathway in neurons and fibroblasts from patients with huntington’s
disease. Neurosci Bulletin 35(6):1024–1034. https://doi.org/10.1007/s12264-019-00421-5
Yerbanga RS, Lucantoni L, Ouédraogo RK, Da DF, Yao FA, Yaméogo KB, Churcher TS,
Lupidi G, Taglialatela-Scafati O, Gouagna LC, Cohuet A, Christophides GK, Ouédraogo JB,
Habluetzel A (2014) Transmission blocking activity of Azadirachta indica and Guiera
senegalensis extracts on the sporogonic development of Plasmodium falciparum field isolates
in Anopheles coluzzii mosquitoes. Parasites Vect 7(1):185. https://doi.org/10.1186/1756-33057-185
Zhang B, Au Q, Yoon IS, Tremblay MH, Yip G, Zhou Y, Barber JR, Ng SC (2009) Identification
of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress
induced injury. Biochem Biophys Res Commun 390(3):925–930. https://doi.org/10.1016/j.
bbrc.2009.10.079
586
Y. S. Ong et al.