Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome
activation and cytokine production: Evidence of a multitarget compound. Pharmacol Res
115:65–77. https://doi.org/10.1016/j.phrs.2016.09.015
Brandt GEL, Schmidt MD, Prisinzano TE, Blagg BSJ (2008) Gedunin, a novel Hsp90 inhibitor:
semisynthesis of derivatives and preliminary structure−activity relationships. J Med Chem 51
(20):6495–6502. https://doi.org/10.1021/jm8007486
Céspedes CL, Calderón JS, Lina L, Aranda E (2000) Growth inhibitory effects on fall armyworm
Spodoptera frugiperda of some limonoids isolated from Cedrela spp.(Meliaceae). J Agric Food
Chem 48(5):1903–1908
Cespedes CL, Lina-Garcia L, Kubo I, Salazar JR, Ariza-Castolo A, Alarcon J, Aqueveque P,
Werner E, Seigler DS (2016) Calceolaria integrifolia sl complex, reduces feeding and growth
of Acanthoscelides obtectus, and Epilachna varivestis. A new source of bioactive compounds
against dry bean pests. Ind Crops Prod 89:257–267
Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, Cannon J,
Venema RC, Catravas JD (2007) Heat shock protein 90 inhibitors prolong survival, attenuate
inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med 176
(7):667–675. https://doi.org/10.1164/rccm.200702-291OC
Chaves TP, Clementino EL, Felismino DC, Alves RR, Vasconcellos A, Coutinho HD,
Medeiros AC (2015) Antibiotic resistance modulation by natural products obtained from
Nasutitermes corniger (Motschulsky, 1855) and its nest. Saudi J Biol Sci 22(4):404–408.
https://doi.org/10.1016/j.sjbs.2014.12.005
Chianese G, Yerbanga SR, Lucantoni L, Habluetzel A, Basilico N, Taramelli D, Fattorusso E, and
Taglialatela-Scafati O (2010) J Nat Prod 73(8):1448–1452. https://doi.org/10.1021/np100325q
Conte FP, Ferraris FK, Costa TEMM, Pacheco P, Seito LN, Verri WA Jr, Cunha FQ, Penido C,
Henriques MG (2015) Effect of gedunin on acute articular inflammation and hypernociception
in mice. Molecules (Basel, Switzerland) 20(2):2636–2657. https://doi.org/10.3390/
molecules20022636
Davies J, Davies D (2010) Origins and evolution of antibiotic resistance. Microbiol Mol Biol
Rev MMBR 74(3):417–433. https://doi.org/10.1128/mmbr.00016-10
Efferth T, Zacchino S, Georgiev MI, Liu L, Wagner H, Panossian A (2015) Nobel Prize for
artemisinin brings phytotherapy into the spotlight. Phytomed Int J Phytotherapy
Phytopharmacol 22(13):A1-3. https://doi.org/10.1016/j.phymed.2015.10.003
Ferraris FK, Moret KH, Figueiredo AB, Penido C, Henriques M (2012) Gedunin, a natural
tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.
Int Immunopharmacol 14(1):82–93. https://doi.org/10.1016/j.intimp.2012.06.002
Frank S (2014) Treatment of Huntington’’s disease. Neurotherapeutics 11(1):153–160. https://doi.
org/10.1007/s13311-013-0244-z
Garg G, Khandelwal A, Blagg BS (2016) Anti-cancer inhibitors of Hsp90 function: beyond the
usual suspects. Adv Cancer Res 129:51–88. https://doi.org/10.1016/bs.acr.2015.12.001
Gupta SC, Prasad S, Tyagi AK, Kunnumakkara AB, Aggarwal BB (2017) Neem (Azadirachta
indica): an Indian traditional panacea with modern molecular basis. Phytomed Int J
Phytotherapy Phytopharmacol 34:14–20. https://doi.org/10.1016/j.phymed.2017.07.001
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K,
Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR (2006) Gene expression
signature-based chemical genomic prediction identifies a novel class of HSP90 pathway
modulators. Cancer Cell 10(4):321–330. https://doi.org/10.1016/j.ccr.2006.09.005
Jang S-W, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q,
Ressler KJ, Ye K (2010) Deoxygedunin, a natural product with potent neurotrophic activity in
mice. PLoS ONE 5(7):e11528. https://doi.org/10.1371/journal.pone.0011528
Johnson J, Venugopal A, Kwatra D, Roby K, Godwin A, Anant S (2014) Abstract 4553: Gedunin,
a novel HSP-90 inhibitor, synergizes with cisplatin and paclitaxel to inhibit growth of
chemoresistant ovarian cancer cell lines. Can Res 74(19 Supplement):4553–4553. https://doi.
org/10.1158/1538-7445.am2014-4553
16 An Overview of the Bioactivities of Gedunin
583
activation and cytokine production: Evidence of a multitarget compound. Pharmacol Res
115:65–77. https://doi.org/10.1016/j.phrs.2016.09.015
Brandt GEL, Schmidt MD, Prisinzano TE, Blagg BSJ (2008) Gedunin, a novel Hsp90 inhibitor:
semisynthesis of derivatives and preliminary structure−activity relationships. J Med Chem 51
(20):6495–6502. https://doi.org/10.1021/jm8007486
Céspedes CL, Calderón JS, Lina L, Aranda E (2000) Growth inhibitory effects on fall armyworm
Spodoptera frugiperda of some limonoids isolated from Cedrela spp.(Meliaceae). J Agric Food
Chem 48(5):1903–1908
Cespedes CL, Lina-Garcia L, Kubo I, Salazar JR, Ariza-Castolo A, Alarcon J, Aqueveque P,
Werner E, Seigler DS (2016) Calceolaria integrifolia sl complex, reduces feeding and growth
of Acanthoscelides obtectus, and Epilachna varivestis. A new source of bioactive compounds
against dry bean pests. Ind Crops Prod 89:257–267
Chatterjee A, Dimitropoulou C, Drakopanayiotakis F, Antonova G, Snead C, Cannon J,
Venema RC, Catravas JD (2007) Heat shock protein 90 inhibitors prolong survival, attenuate
inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med 176
(7):667–675. https://doi.org/10.1164/rccm.200702-291OC
Chaves TP, Clementino EL, Felismino DC, Alves RR, Vasconcellos A, Coutinho HD,
Medeiros AC (2015) Antibiotic resistance modulation by natural products obtained from
Nasutitermes corniger (Motschulsky, 1855) and its nest. Saudi J Biol Sci 22(4):404–408.
https://doi.org/10.1016/j.sjbs.2014.12.005
Chianese G, Yerbanga SR, Lucantoni L, Habluetzel A, Basilico N, Taramelli D, Fattorusso E, and
Taglialatela-Scafati O (2010) J Nat Prod 73(8):1448–1452. https://doi.org/10.1021/np100325q
Conte FP, Ferraris FK, Costa TEMM, Pacheco P, Seito LN, Verri WA Jr, Cunha FQ, Penido C,
Henriques MG (2015) Effect of gedunin on acute articular inflammation and hypernociception
in mice. Molecules (Basel, Switzerland) 20(2):2636–2657. https://doi.org/10.3390/
molecules20022636
Davies J, Davies D (2010) Origins and evolution of antibiotic resistance. Microbiol Mol Biol
Rev MMBR 74(3):417–433. https://doi.org/10.1128/mmbr.00016-10
Efferth T, Zacchino S, Georgiev MI, Liu L, Wagner H, Panossian A (2015) Nobel Prize for
artemisinin brings phytotherapy into the spotlight. Phytomed Int J Phytotherapy
Phytopharmacol 22(13):A1-3. https://doi.org/10.1016/j.phymed.2015.10.003
Ferraris FK, Moret KH, Figueiredo AB, Penido C, Henriques M (2012) Gedunin, a natural
tetranortriterpenoid, modulates T lymphocyte responses and ameliorates allergic inflammation.
Int Immunopharmacol 14(1):82–93. https://doi.org/10.1016/j.intimp.2012.06.002
Frank S (2014) Treatment of Huntington’’s disease. Neurotherapeutics 11(1):153–160. https://doi.
org/10.1007/s13311-013-0244-z
Garg G, Khandelwal A, Blagg BS (2016) Anti-cancer inhibitors of Hsp90 function: beyond the
usual suspects. Adv Cancer Res 129:51–88. https://doi.org/10.1016/bs.acr.2015.12.001
Gupta SC, Prasad S, Tyagi AK, Kunnumakkara AB, Aggarwal BB (2017) Neem (Azadirachta
indica): an Indian traditional panacea with modern molecular basis. Phytomed Int J
Phytotherapy Phytopharmacol 34:14–20. https://doi.org/10.1016/j.phymed.2017.07.001
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K,
Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR (2006) Gene expression
signature-based chemical genomic prediction identifies a novel class of HSP90 pathway
modulators. Cancer Cell 10(4):321–330. https://doi.org/10.1016/j.ccr.2006.09.005
Jang S-W, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q,
Ressler KJ, Ye K (2010) Deoxygedunin, a natural product with potent neurotrophic activity in
mice. PLoS ONE 5(7):e11528. https://doi.org/10.1371/journal.pone.0011528
Johnson J, Venugopal A, Kwatra D, Roby K, Godwin A, Anant S (2014) Abstract 4553: Gedunin,
a novel HSP-90 inhibitor, synergizes with cisplatin and paclitaxel to inhibit growth of
chemoresistant ovarian cancer cell lines. Can Res 74(19 Supplement):4553–4553. https://doi.
org/10.1158/1538-7445.am2014-4553
16 An Overview of the Bioactivities of Gedunin
583