Krishnan et al. isolated alstobrogaline (68, Fig. 14.13) from A. scholaris leaves
and evaluated for the in vitro cytotoxicity in various human breast cancer cell lines
(Krishnan et al. 2019). 68 exhibited significant activity in human breast adenocarcinoma (DA-MB-231) and MCF-7 cells (IC 50 = 25.3 and 24.1 µM, respectively), while a poor activity was observed in MDA-MB-468, human breast cancer
(SK-BR-3), and T47D cells (IC 50 > 30 µM).
N
H
N
O
MeOOC
O
O
O
HO
HO
OH
O
O
N
HN
O
H
N
H
N
O
MeOOC
O
O
O
HO
HO
OH
O
O
N
HN
O
H
Alstoniasidine A (66)
Alstoniasidine B (67)
Fig. 14.12 Chemical structures of alstoniasidine A and B (66 and 67)
Table 14.8 Cytotoxic effects
of alstoniasidine A, B (66 and
67) and taxol against GSC
cells
Compound
Cell lines
IC 50 values (µg/mL)
66
67
Taxol
GSC-12#
30.9
20.1
12.5
GSC-18#
19.2
16.1
10.4
Alstobrogaline (68)
N
H
N
O
N
H
MeOOC
Fig. 14.13 Chemical
structure of alstobrogaline
(68)
14 Pharmaceutical Application of Bio-actives …
477
and evaluated for the in vitro cytotoxicity in various human breast cancer cell lines
(Krishnan et al. 2019). 68 exhibited significant activity in human breast adenocarcinoma (DA-MB-231) and MCF-7 cells (IC 50 = 25.3 and 24.1 µM, respectively), while a poor activity was observed in MDA-MB-468, human breast cancer
(SK-BR-3), and T47D cells (IC 50 > 30 µM).
N
H
N
O
MeOOC
O
O
O
HO
HO
OH
O
O
N
HN
O
H
N
H
N
O
MeOOC
O
O
O
HO
HO
OH
O
O
N
HN
O
H
Alstoniasidine A (66)
Alstoniasidine B (67)
Fig. 14.12 Chemical structures of alstoniasidine A and B (66 and 67)
Table 14.8 Cytotoxic effects
of alstoniasidine A, B (66 and
67) and taxol against GSC
cells
Compound
Cell lines
IC 50 values (µg/mL)
66
67
Taxol
GSC-12#
30.9
20.1
12.5
GSC-18#
19.2
16.1
10.4
Alstobrogaline (68)
N
H
N
O
N
H
MeOOC
Fig. 14.13 Chemical
structure of alstobrogaline
(68)
14 Pharmaceutical Application of Bio-actives …
477