6.2.5 High Throughput Screening (HTS) for Plants
and Bioactive Compounds
Some medicinal plants are currently under high throughput screening for a quick
assessment of pharmacologically important hit molecules that could be utilized as a
lead molecule in drug development. Some of the medicinally important plants
currently under research for their immunomodulatory utility are given in Tables 6.3
and 6.4.
Table 6.3 List of plants with immunomodulatory potential (Nair et al. 2019; Kumar et al. 2012)
S. No. Name of the plant
Parts used
Compounds isolated
1
Acanthopanax sessiliflorus
(Rupr. and Maxim.)
(Araliaceae)
Root, berry, leaf Saponins, coumarins, lignans,
syringin, eleutheroside
syringaresinol, phenylpropane,
flavones, beta-sitosterol
2
Achyranthes bidentate
(Amaranthaceae)
Root, leaf, seed Triterpenoid, alkaloids, ketosteroids,
saponins, sterols, flavonoids,
anthraquinones, organic acids
3
Achyrocline satureioides
(Asteraceae)
Flower
Luteolin, 3-O-methyl quercetin,
flavonoids quercetin
4
Aconitum carmichaeliim
(Ranunculaceae)
Root
Unesterified-diterpene
diester-diterpene alkaloids, alkaloids,
monoester-diterpene alkaloids
5
Actinidia macrosperma C.
F. Liang Actinidiaceae
Berry
Phenolic compounds, alkaloids
6
Aeginetia indica
(Orobanchaceae)
Whole plant
Glycoproteins, terpenoids, cichoric
acid, macrocyclic lactones,
polysaccharides, alkylamides
7
Albizia julibrissin
(Fabaceae)
Bark, flower
Aromatic ethyl esters, dicarboxylic
esters
8
Aloe vera Tourn. ex Linn.
(Liliaceae)
Leaf
Glucomannans, sterols,
anthraquinones, lipids, vitamins,
amino acids, glycosides
9
Alsophila spinulosa
(Cyatheaceae)
Stem, leaf
Diploptene, glucopyranose,
beta-sitosterol, astragalin
10
Angelica acutiloba
(Apiaceae)
Root, aerial part Ferulic acid, Z-ligustilide,
tokiaerialide, bergaptol
11
Angelica sinensis
(Apiaceae)
Root
Polysaccharides, ferulic acid,
Z-ligustilide
12
Aralia mandshurica
(Araliaceae)
Root
Aralosides (A, B, C), flavonoids,
polysaccharides, saponins, sterols
terpenoid acids, terpenoid
13
Arnica montana
(Asteraceae)
Flower
Coumarins, lignans, phenolic acids,
oligosaccharides, sesquiterpene
lactones, flavonoids, alkaloids,
carotenoids, pyrrolizidine
(continued)
226
V. K. Gurjar and D. Pal
and Bioactive Compounds
Some medicinal plants are currently under high throughput screening for a quick
assessment of pharmacologically important hit molecules that could be utilized as a
lead molecule in drug development. Some of the medicinally important plants
currently under research for their immunomodulatory utility are given in Tables 6.3
and 6.4.
Table 6.3 List of plants with immunomodulatory potential (Nair et al. 2019; Kumar et al. 2012)
S. No. Name of the plant
Parts used
Compounds isolated
1
Acanthopanax sessiliflorus
(Rupr. and Maxim.)
(Araliaceae)
Root, berry, leaf Saponins, coumarins, lignans,
syringin, eleutheroside
syringaresinol, phenylpropane,
flavones, beta-sitosterol
2
Achyranthes bidentate
(Amaranthaceae)
Root, leaf, seed Triterpenoid, alkaloids, ketosteroids,
saponins, sterols, flavonoids,
anthraquinones, organic acids
3
Achyrocline satureioides
(Asteraceae)
Flower
Luteolin, 3-O-methyl quercetin,
flavonoids quercetin
4
Aconitum carmichaeliim
(Ranunculaceae)
Root
Unesterified-diterpene
diester-diterpene alkaloids, alkaloids,
monoester-diterpene alkaloids
5
Actinidia macrosperma C.
F. Liang Actinidiaceae
Berry
Phenolic compounds, alkaloids
6
Aeginetia indica
(Orobanchaceae)
Whole plant
Glycoproteins, terpenoids, cichoric
acid, macrocyclic lactones,
polysaccharides, alkylamides
7
Albizia julibrissin
(Fabaceae)
Bark, flower
Aromatic ethyl esters, dicarboxylic
esters
8
Aloe vera Tourn. ex Linn.
(Liliaceae)
Leaf
Glucomannans, sterols,
anthraquinones, lipids, vitamins,
amino acids, glycosides
9
Alsophila spinulosa
(Cyatheaceae)
Stem, leaf
Diploptene, glucopyranose,
beta-sitosterol, astragalin
10
Angelica acutiloba
(Apiaceae)
Root, aerial part Ferulic acid, Z-ligustilide,
tokiaerialide, bergaptol
11
Angelica sinensis
(Apiaceae)
Root
Polysaccharides, ferulic acid,
Z-ligustilide
12
Aralia mandshurica
(Araliaceae)
Root
Aralosides (A, B, C), flavonoids,
polysaccharides, saponins, sterols
terpenoid acids, terpenoid
13
Arnica montana
(Asteraceae)
Flower
Coumarins, lignans, phenolic acids,
oligosaccharides, sesquiterpene
lactones, flavonoids, alkaloids,
carotenoids, pyrrolizidine
(continued)
226
V. K. Gurjar and D. Pal