paracetamol tablets. The in vitro dissolution results showed that 98.55% paracetamol releasing within 30 min from the paracetamol tablets prepared using 0.125%
gum odina as binder. However, the in vitro paracetamol releasing was slowed from
the paracetamol tablets prepared using 0.25 and 0.375% gum odina. Gum odina
was also studied as controlled release matrix former for the preparations of tolterodine tartarate and pioglitazone HCl matrix tablets (Sinha et al. 2011). Both the
tolterodine tartarate and pioglitazone HCl matrix tablets exhibited a controlled drug
releasing over a prolonged period (Fig. 3.2). Pachuau and Mazumdar (2012)
assessed the efficacy of Albizia procera gum as release retardant excipients in
matrix tablets. They formulated paracetamol tablets using Albizia procera gum and
observed a controlled sustained releasing of drug from these matrix tablets over12
h. Ofori-Kwakye et al. (2016) prepared matrix tablets of diclofenac sodium and
metformin HCl by direct compression using cashew gum, xanthan gum and
hydroxypropyl methylcellulose as release retardants. These matrix tablets exhibited
extended release of drugs over a longer period. Hasnain et al. (2017a) used cashew
Fig. 3.2 a In vitro mean cumulative percentage release of pioglitazone HCl from matrices
containing various proportions of gum odina. b In vitro mean cumulative% release of tolterodine
tartarate from matrices containing various proportions of gum odina. Each point is the mean
value of three samples (n = 3) (Sinha et al. 2011; Copyright @ 2010, with permission from
Elsevier Ltd.)
102
A. K. Nayak et al.
gum odina as binder. However, the in vitro paracetamol releasing was slowed from
the paracetamol tablets prepared using 0.25 and 0.375% gum odina. Gum odina
was also studied as controlled release matrix former for the preparations of tolterodine tartarate and pioglitazone HCl matrix tablets (Sinha et al. 2011). Both the
tolterodine tartarate and pioglitazone HCl matrix tablets exhibited a controlled drug
releasing over a prolonged period (Fig. 3.2). Pachuau and Mazumdar (2012)
assessed the efficacy of Albizia procera gum as release retardant excipients in
matrix tablets. They formulated paracetamol tablets using Albizia procera gum and
observed a controlled sustained releasing of drug from these matrix tablets over12
h. Ofori-Kwakye et al. (2016) prepared matrix tablets of diclofenac sodium and
metformin HCl by direct compression using cashew gum, xanthan gum and
hydroxypropyl methylcellulose as release retardants. These matrix tablets exhibited
extended release of drugs over a longer period. Hasnain et al. (2017a) used cashew
Fig. 3.2 a In vitro mean cumulative percentage release of pioglitazone HCl from matrices
containing various proportions of gum odina. b In vitro mean cumulative% release of tolterodine
tartarate from matrices containing various proportions of gum odina. Each point is the mean
value of three samples (n = 3) (Sinha et al. 2011; Copyright @ 2010, with permission from
Elsevier Ltd.)
102
A. K. Nayak et al.