418
R. Mankamna Kumari et al.
Fig. 4 Represents effect of shape on biological properties and therapeutics
analogous to filovirus and also proplatelets that break up into smaller platelets in
blood stream. Thus, long flexibility and length may contribute to long circulation
with optimal length up to 8 μm. Also paclitaxel loaded filomicelles showed higher
penetration in the tumor stroma that lead to tumor shrinkage and cell apoptosis.
Muzykantov’s group also studied the effect of disk-shaped carriers toward intercellular adhesion molecules and found longer half-lives (Christian et al. 2009; Geng
et al. 2007; Muro et al. 2008; Yoo et al. 2011). Similarly, in another study Decuzzi
and Ferrari’s group investigated the effect of silicon-based particles within diameter 700–3 μm with quasi-hemispherical, cylindrical, and discoidal shapes. From the
studies it was observed that discoidal particles accumulated more efficiently in most
of the organs which could be attributed to its higher rotational inertia and surface of
contact (Decuzzi et al. 2010). In addition to this, other studies have demonstrated
profound effects of shape on phagocytosis as well. Mitragotri’s group showed the
effect of poly-styrene particles of different sizes and shapes on alveolar macrophages.
They found that the cells attached on the major axis of elliptical disk were internalized efficiently within 3 min while cells that were attached to the flat side of disk
did not internalize the particle. It was discerned that the tangent angles of the point
of attachment of the particles determined its uptake, validated by computational
approaches (Champion and Mitragotri 2006; Lamprecht et al. 1999; Yang and Ma
2010). Rod-shaped particles such as pegylated gold nanorods have reduced clearance with longer circulation time in relative to spherical particles. In this support,
R. Mankamna Kumari et al.
Fig. 4 Represents effect of shape on biological properties and therapeutics
analogous to filovirus and also proplatelets that break up into smaller platelets in
blood stream. Thus, long flexibility and length may contribute to long circulation
with optimal length up to 8 μm. Also paclitaxel loaded filomicelles showed higher
penetration in the tumor stroma that lead to tumor shrinkage and cell apoptosis.
Muzykantov’s group also studied the effect of disk-shaped carriers toward intercellular adhesion molecules and found longer half-lives (Christian et al. 2009; Geng
et al. 2007; Muro et al. 2008; Yoo et al. 2011). Similarly, in another study Decuzzi
and Ferrari’s group investigated the effect of silicon-based particles within diameter 700–3 μm with quasi-hemispherical, cylindrical, and discoidal shapes. From the
studies it was observed that discoidal particles accumulated more efficiently in most
of the organs which could be attributed to its higher rotational inertia and surface of
contact (Decuzzi et al. 2010). In addition to this, other studies have demonstrated
profound effects of shape on phagocytosis as well. Mitragotri’s group showed the
effect of poly-styrene particles of different sizes and shapes on alveolar macrophages.
They found that the cells attached on the major axis of elliptical disk were internalized efficiently within 3 min while cells that were attached to the flat side of disk
did not internalize the particle. It was discerned that the tangent angles of the point
of attachment of the particles determined its uptake, validated by computational
approaches (Champion and Mitragotri 2006; Lamprecht et al. 1999; Yang and Ma
2010). Rod-shaped particles such as pegylated gold nanorods have reduced clearance with longer circulation time in relative to spherical particles. In this support,