231
8. Fraga BM (2013) Natural sesquiterpenoids. Nat Prod Rep 30:1226
9. Seaman FC (1982) Sesquiterpene lactones as taxonomic characters in the Asteraceae. Bot
Rev 48:121
10. Yaoita Y, Kikuchi M, Machida K (2012) Terpenoids and related compounds from plants of
the family Compositae (Asteraceae). Nat Prod Commun 7:533
11. Ishii H, Tozyo T, Minato H (1965) Studies on sesquiterpenoids-IX. Structure of ligularol and
ligularone from Ligularia sibirica Cass. Tetrahedron 21:2605
12. Tada M, Moriyama Y, Tanahashi Y, Takahashi T, Fukuyama M, Sato K (1971) New furanosesquiterpenes from Ligularia japonica Less. Furanoeremophilane-6β,10β-diol,
10β-hydroxy-6β-methoxyfuranoeremophilane and 10β-hydroxyfuranoeremophilan-6β-yl
2′ξ-methylbutanoate. Tetrahedron Lett 10 4007
13. Bohlmann F, Ehlers D, Zdero C, Grenz M (1977) Über Inhaltsstoffe der Gattung Ligularia.
Chem Ber 110:2640
14. Yang JL, Wang R, Shi YP (2011) Phytochemicals and biological activities of Ligularia species. Nat Prod Bioprospect 1:1
15. Kuorda C, Nishio E (2007) Substituent effect in color of Ehrlich’s test of tetrahydrobenzofuran. Nat Prod Commun 2:581
16. Connolly JD, Hill RA (1991) Dictionary of terpenoids. Chapman & Hall, London
17. Nagano H, Torihata A, Matsushima M, Hanai R, Saito Y, Baba M, Tanio Y, Okamoto Y,
Takashima Y, Ichihara M, Gong X, Kuroda C, Tori M (2009) Chemical and genetic study of
Ligularia cyathiceps in Yunnan Province of China. Helv Chim Acta 92:2071
18. Hanai R, Tanabe S, Aoyama N, Okamoto Y, Tori M, Zhang N, Gong X, Kuroda C (2016)
Chemical and genetic study of two Ligularia hybrids in Shangri-La county, Yunnan province,
China. Nat Prod Commun 11:1057
19. Tori M, Tanio Y, Okamoto Y, Saito Y, Gong X, Kuroda C, Hanai R (2008) Chemical constituents of Ligularia franchetiana collected in Yunnan Province of China. Heterocycles 75:2029
20. Bohlmann F, Knoll KH (1979) Ein neues Norsesquiterpen und andere Inhaltsstoffe aus
Ligularia-Arten. Phytochemistry 18:877
21. Shimizu A, Inoue K, Ichihara M, Hanai R, Saito Y, Okamoto Y, Tori M, Gong X, Kuroda
C (2015) Chemotypes of Ligularia vellerea, its hybrids, and L. melanothyrsa. Nat Prod
Commun 10:9
22. Tori M, Watanabe A, Matsuo S, Okamoto Y, Tachikawa K, Takaoka S, Gong X, Kuroda C,
Hanai R (2008) Diversity of Ligularia kanaitzensis in sesquiterpenoid composition and neutral DNA sequences. Tetrahedron 64:4486
23. Saito Y, Hattori M, Iwamoto Y, Takashima Y, Mihara K, Sasaki Y, Fujiwara M, Sakaoku M,
Shimizu A, Chao X, Kuroda C, Gong X, Hanai R, Tori M (2011) Overlapping chemical
and genetic diversity in Ligularia lamarum and Ligularia subspicata. Isolation of ten new
eremophilanes and a new seco-bakkane compound. Tetrahedron 67:2220
24. Tori M, Okamoto Y, Tachikawa K, Mihara K, Watanabe A, Sakaoku M, Takaoka S, Tanaka
M, Gong X, Kuroda C, Hattori M, Hanai R (2008) Isolation of new eremophilane-type sesquiterpenoids, subspicatins A–D and subspicatolide from Ligularia subspicata, and chemical
and genetic diversity of the species. Tetrahedron 64:9136
25. Kuroda C, Itoh T, Suzuki Y, Suzuki Y, Okamoto Y, Tori M, Hanai R, Gong X (2018) Chemical
and genetic identity of Ligularia tsangchanensis and L. muliensis. Isolation of a cacalol precursor from a hybrid of L. tsangchanensis and L. vellerea. Nat Prod Commun 13:389
26. Tori M, Nakamizo H, Mihara K, Sato M, Okamoto Y, Nakashima K, Tanaka M, Saito Y, Sono
M, Gong X, Shen Y, Hanai R, Kuroda C (2008) Chemical and genetic diversity of Ligularia
vellerea in Yunnan, China. Phytochemistry 69:1158
27. Nakashima K, Hoshiyama K, Hayami C, Sakaoku M, Okamoto Y, Kuroda C, Gong X, Tori
M (2018) Eremophilane sesquiterpenoids and nor- and dinorsesquiterpenoids from Ligularia
virgaurea collected in China. Nat Prod Commun 13:795
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity…
8. Fraga BM (2013) Natural sesquiterpenoids. Nat Prod Rep 30:1226
9. Seaman FC (1982) Sesquiterpene lactones as taxonomic characters in the Asteraceae. Bot
Rev 48:121
10. Yaoita Y, Kikuchi M, Machida K (2012) Terpenoids and related compounds from plants of
the family Compositae (Asteraceae). Nat Prod Commun 7:533
11. Ishii H, Tozyo T, Minato H (1965) Studies on sesquiterpenoids-IX. Structure of ligularol and
ligularone from Ligularia sibirica Cass. Tetrahedron 21:2605
12. Tada M, Moriyama Y, Tanahashi Y, Takahashi T, Fukuyama M, Sato K (1971) New furanosesquiterpenes from Ligularia japonica Less. Furanoeremophilane-6β,10β-diol,
10β-hydroxy-6β-methoxyfuranoeremophilane and 10β-hydroxyfuranoeremophilan-6β-yl
2′ξ-methylbutanoate. Tetrahedron Lett 10 4007
13. Bohlmann F, Ehlers D, Zdero C, Grenz M (1977) Über Inhaltsstoffe der Gattung Ligularia.
Chem Ber 110:2640
14. Yang JL, Wang R, Shi YP (2011) Phytochemicals and biological activities of Ligularia species. Nat Prod Bioprospect 1:1
15. Kuorda C, Nishio E (2007) Substituent effect in color of Ehrlich’s test of tetrahydrobenzofuran. Nat Prod Commun 2:581
16. Connolly JD, Hill RA (1991) Dictionary of terpenoids. Chapman & Hall, London
17. Nagano H, Torihata A, Matsushima M, Hanai R, Saito Y, Baba M, Tanio Y, Okamoto Y,
Takashima Y, Ichihara M, Gong X, Kuroda C, Tori M (2009) Chemical and genetic study of
Ligularia cyathiceps in Yunnan Province of China. Helv Chim Acta 92:2071
18. Hanai R, Tanabe S, Aoyama N, Okamoto Y, Tori M, Zhang N, Gong X, Kuroda C (2016)
Chemical and genetic study of two Ligularia hybrids in Shangri-La county, Yunnan province,
China. Nat Prod Commun 11:1057
19. Tori M, Tanio Y, Okamoto Y, Saito Y, Gong X, Kuroda C, Hanai R (2008) Chemical constituents of Ligularia franchetiana collected in Yunnan Province of China. Heterocycles 75:2029
20. Bohlmann F, Knoll KH (1979) Ein neues Norsesquiterpen und andere Inhaltsstoffe aus
Ligularia-Arten. Phytochemistry 18:877
21. Shimizu A, Inoue K, Ichihara M, Hanai R, Saito Y, Okamoto Y, Tori M, Gong X, Kuroda
C (2015) Chemotypes of Ligularia vellerea, its hybrids, and L. melanothyrsa. Nat Prod
Commun 10:9
22. Tori M, Watanabe A, Matsuo S, Okamoto Y, Tachikawa K, Takaoka S, Gong X, Kuroda C,
Hanai R (2008) Diversity of Ligularia kanaitzensis in sesquiterpenoid composition and neutral DNA sequences. Tetrahedron 64:4486
23. Saito Y, Hattori M, Iwamoto Y, Takashima Y, Mihara K, Sasaki Y, Fujiwara M, Sakaoku M,
Shimizu A, Chao X, Kuroda C, Gong X, Hanai R, Tori M (2011) Overlapping chemical
and genetic diversity in Ligularia lamarum and Ligularia subspicata. Isolation of ten new
eremophilanes and a new seco-bakkane compound. Tetrahedron 67:2220
24. Tori M, Okamoto Y, Tachikawa K, Mihara K, Watanabe A, Sakaoku M, Takaoka S, Tanaka
M, Gong X, Kuroda C, Hattori M, Hanai R (2008) Isolation of new eremophilane-type sesquiterpenoids, subspicatins A–D and subspicatolide from Ligularia subspicata, and chemical
and genetic diversity of the species. Tetrahedron 64:9136
25. Kuroda C, Itoh T, Suzuki Y, Suzuki Y, Okamoto Y, Tori M, Hanai R, Gong X (2018) Chemical
and genetic identity of Ligularia tsangchanensis and L. muliensis. Isolation of a cacalol precursor from a hybrid of L. tsangchanensis and L. vellerea. Nat Prod Commun 13:389
26. Tori M, Nakamizo H, Mihara K, Sato M, Okamoto Y, Nakashima K, Tanaka M, Saito Y, Sono
M, Gong X, Shen Y, Hanai R, Kuroda C (2008) Chemical and genetic diversity of Ligularia
vellerea in Yunnan, China. Phytochemistry 69:1158
27. Nakashima K, Hoshiyama K, Hayami C, Sakaoku M, Okamoto Y, Kuroda C, Gong X, Tori
M (2018) Eremophilane sesquiterpenoids and nor- and dinorsesquiterpenoids from Ligularia
virgaurea collected in China. Nat Prod Commun 13:795
Chemical Constituents of Ligularia Species (Asteraceae) and Their Diversity…