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Fig. 16.5 Proposed mechanism for DMs analogue to inhibit the entry of SARS-CoV-2 into human
body
magnetic bio-char (MBC) and magnetic nano particles (MNP) will be quite appreciable because these two catalysts can minimize the energy requirement also with
time limit in the synthesis of DMs. So, a pharmaceutical green sustainable approach
will be suitable to synthesis DMs drug which will contain IL as both solvent and
catalyst but a number of studies show that the extraction of IL from synthesis reaction
is quite a difficult process [9].
Hence, a supportive catalyst is required for easy extraction of IL from reaction
mixture. Magnetic bio-char (MBC) and magnetic nano particles (MNPs) are considered as the promising candidates for supportive catalyst as they can easily extract
IL from synthesis reaction via magnetic separation method (Fig. 16.6). The sol-gel
method provides an effective means to develop the eco-friendly biocatalysts MBC-IL
and MNP-IL. Moreover, each biocatalyst acts as traveling vehicle for the delivery
of drug in the drug delivery system. Therefore, the recent advantages of DMs in
the treatment of SARS-CoV-2 attract us to develop the green analogue of DMs by
reviewing the green chemistry approach applied to the synthesis of different drugs. In
this context, the present investigation provides an effective means to develop a green
and sustainable DMs analogue scaffold on the basis of reviewing the IL, MBC, and
MNP as green solvent and catalyst in developing various drugs. Therefore, this study
reviews at first the DMs analogue synthesized by chemical methods used in past few
decades. After that, based on several former studies, it will be reviewed that how IL,
MBC, and MNP can play an important role to derive green DMs analogue which
will be cheap, non-hazardous and biocompatible via the green principle approach
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