177
Table 2 (continued)
Marker
Gen/hap/
allele
Semang
Senoi
P-M
Bateq Kensiu Lanoh CW Semai OK
CytokineIL-4-1098/-590/-33 gene
SNPs
TTT
TTC
TCT
TCC
GTT
GTC
GCT
GCC
0.80
0.00
0.00
0.18
0.00
0.00
0.000
0.02
0.51
0.00
0.00
0.43
0.00
0.00
0.00
0.06
0.72
0.00
0.00
0.16
0.00
0.00
0.00
0.12
0.74
0.00
0.00
0.02
0.00
0.00
0.00
0.24
0.61
0.09
0.00
0.17
0.00
0.00
0.01
0.13
0.64
0.00
0.09
0.23
0.00
0.00
0.00
0.05
CytokineIL-6-597/-174 gene SNPs
GG
CG
GA
CA
0.72
0.24
0.00
0.04
0.88
0.11
0.01
0.00
0.62
0.34
0.00
0.04
0.64
0.19
0.05
0.12
0.73
0.26
0.00
0.01
0.64
0.36
0.00
0.00
CytokineIL-10-1082/-819/-592 gene
SNPs
GCC
GCA
GAC
ACC
ACA
ATC
ATA
GTA
GTC
0.05
0.00
0.00
0.57
0.00
0.04
0.31
0.01
0.02
0.07
0.00
0.00
0.47
0.01
0.00
0.44
0.00
0.00
0.06
0.00
0.00
0.20
0.00
0.02
0.72
0.00
0.00
0.27
0.00
0.00
0.06
0.02
0.02
0.64
0.00
0.00
0.10
0.00
0.00
0.23
0.02
0.00
0.66
0.00
0.00
0.50
0.00
0.00
0.00
0.00
0.00
0.50
0.00
0.00
δ
HLA-A
02:01
11:01
24:02
24:07
33:03
•
•
•
•
•
0.41
0.14
0.07
0.24
0.00
0.26
0.04
0.12
0.32
0.08
•
•
•
•
•
0.07
0.04
0.20
0.41
0.00
0.15
0.27
0.10
0.21
0.17
δ
HLA-B
13:01
15:02
15:13
15:25
18:01
35:05
•
•
•
•
•
•
0.14
0.00
0.19
0.02
0.19
0.05
0.08
0.02
0.10
0.00
0.28
0.14
•
•
•
•
•
•
0.00
0.17
0.16
0.00
0.17
0.15
0.08
0.06
0.13
0.15
0.15
0.06
δ
HLA-DRB1
09:01
12:02
15:01
15:02
16:02
•
•
•
•
•
0.19
0.14
0.19
0.14
0.00
0.32
0.14
0.04
0.30
0.00
•
•
•
•
•
0.15
0.29
0.11
0.16
0.16
0.19
0.15
0.10
0.08
0.21
There are many genetic similarities and differences observed between Orang Asli tribes across the
five genetic loci. In addition, differences were also recorded between Orang Asli of similar tribe
(e.g. refer KIR genotype profiles between Bateq, Kensiu and Lanoh of the Semang). Evidence of
reduced genetic variability in Orang Asli is shown by several monomorphic loci (bold) and largely
observed in small Orang Asli subtribes, such as the Bateq and Orang Kanaq. The population data
for KIR, HPA, HNA, cytokine and HLA listed here were compiled from Jinam et  al. (2012),
NurWaliyuddin et al. (2015), Manaf et al. (2016), Norhalifah et al. (2016b), Syafawati et al. (2016)
and Tasnim et al. (2016). Gen genotype, hap haplotype, CW Che Wong, OK Orang Kanaq, • no
data available, δ only the most frequent HLA types in Kensiu, Jahai, Semai and Temuan were listed
A Multidisciplinary Account of the Orang Asli in Peninsular Malaysia