471
Shadkchan Y, Shemesh E, Mirelman D et al (2004) Efficacy of allicin, the reactive molecule of
garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother 53:832–836. https://doi.org/10.1093/jac/dkh174
Shang A, Cao S-Y, Xu X-Y, Gan R-Y, Tang G-Y, Corke H et al (2019) Bioactive compounds and
biological functions of garlic (Allium sativum L.). Foods 8(7):246
Shin I-S, Hong J, Jeon C-M et al (2013) Diallyl-disulfide, an organosulfur compound of garlic,
attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression. Food Chem Toxicol 62:506–513. https://doi.org/10.1016/j.fct.2013.09.012
Shobana S, Akhilender Naidu K (2000) Antioxidant activity of selected Indian spices.
Prostaglandins Leukot Essent Fat Acids. https://doi.org/10.1054/plef.1999.0128
Shukla Y, Kalra N (2007) Cancer chemoprevention with garlic and its constituents. Cancer Lett
247:167–181. https://doi.org/10.1016/j.canlet.2006.05.009
Stevinson C, Pittler MH, Ernst E (2000) Garlic for treating hypercholesterolemia: a
meta-analysis of randomize clinical trials. Ann Intern Med 133:420–429. https://doi.
org/10.7326/0003-4819-133-6-200009190-00009
Stoll A, Seebeck E (1951) Chemical investigations on alliin, the specific principle of garlic. Adv
Enzymol Relat Areas Mol Biol 11:377–400
Sundaram SG, Milner JA (1996) Diallyl disulfide inhibits the proliferation of human
tumor cells in culture. Biochim Biophys Acta Mol basis Dis 1315:15–20. https://doi.
org/10.1016/0925-4439(95)00088-7
Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T et al (2007) Amelioration
of glucose tolerance by hepatic inhibition of nuclear factor κB in db/db mice. Diabetologia
50(1):131–141
Tang H-Y, Xiao Q-G, Xu H-B, Zhang Y (2015) Hypoglycemic activity and acute oral toxicity of
chromium methionine complexes in mice. J Trace Elem Med Biol 29:136–144
Tarozzi A, Angeloni C, Malaguti M et al (2013) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxidative Med Cell Longev 2013:1–10. https://
doi.org/10.1155/2013/415078
Tin AS, Park AH, Sundar SN, Firestone GL (2014) Essential role of the cancer stem/progenitor cell
marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast
cancer cells. BMC Biol 12:72
Toohey J, Cooper A (2014) Thiosulfoxide (Sulfane) sulfur: new chemistry and new regulatory
roles in biology. Molecules 19:12789–12813. https://doi.org/10.3390/molecules190812789
Trio PZ, You S, He X et al (2014) Chemopreventive functions and molecular mechanisms of garlic
organosulfur compounds. Food Funct 5(5):833–844
Tsubura A, Lai Y-C, Kuwata M et al (2011) Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anti Cancer Agents Med Chem 11:249–253
Turos E, Long TE, Konaklieva MI, et al (2002) N-thiolated beta-lactams: novel antibacterial agents
for methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett 12(16):2229–2231.
https://doi.org/10.1016/s0960-894x(02)00343-8
Viswanathan V, Phadatare AG, Mukne A (2014) Antimycobacterial and anti-bacterial activity of
Allium sativum bulbs. Indian J Pharm Sci 76:256–261
Volchegorskiĭ IA, Alekseev MN, Volchegorskaia MI, Rassokhina LM (2008) [Effect of alphalipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med 86(10):52–59. Retrieved from http://europepmc.org/abstract/
MED/19069461
Waag T, Gelhaus C, Rath J et al (2010) Allicin and derivates are cysteine protease inhibitors with
anti-parasitic activity. Bioorganic Med Chem Lett. https://doi.org/10.1016/j.bmcl.2010.07.062
Wang H-C, Pao J, Lin S-Y, Sheen L-Y (2012) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Ann N Y Acad Sci 1271:44–52. https://doi.
org/10.1111/j.1749-6632.2012.06743.x
Warshafsky S, Kamer RS, Sivak SL (1993) Effect of garlic on total serum cholesterol: a metaanalysis. Ann Intern Med 119:599–605
21 Health Benefits of Organosulfur Compounds
Shadkchan Y, Shemesh E, Mirelman D et al (2004) Efficacy of allicin, the reactive molecule of
garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J Antimicrob Chemother 53:832–836. https://doi.org/10.1093/jac/dkh174
Shang A, Cao S-Y, Xu X-Y, Gan R-Y, Tang G-Y, Corke H et al (2019) Bioactive compounds and
biological functions of garlic (Allium sativum L.). Foods 8(7):246
Shin I-S, Hong J, Jeon C-M et al (2013) Diallyl-disulfide, an organosulfur compound of garlic,
attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression. Food Chem Toxicol 62:506–513. https://doi.org/10.1016/j.fct.2013.09.012
Shobana S, Akhilender Naidu K (2000) Antioxidant activity of selected Indian spices.
Prostaglandins Leukot Essent Fat Acids. https://doi.org/10.1054/plef.1999.0128
Shukla Y, Kalra N (2007) Cancer chemoprevention with garlic and its constituents. Cancer Lett
247:167–181. https://doi.org/10.1016/j.canlet.2006.05.009
Stevinson C, Pittler MH, Ernst E (2000) Garlic for treating hypercholesterolemia: a
meta-analysis of randomize clinical trials. Ann Intern Med 133:420–429. https://doi.
org/10.7326/0003-4819-133-6-200009190-00009
Stoll A, Seebeck E (1951) Chemical investigations on alliin, the specific principle of garlic. Adv
Enzymol Relat Areas Mol Biol 11:377–400
Sundaram SG, Milner JA (1996) Diallyl disulfide inhibits the proliferation of human
tumor cells in culture. Biochim Biophys Acta Mol basis Dis 1315:15–20. https://doi.
org/10.1016/0925-4439(95)00088-7
Tamura Y, Ogihara T, Uchida T, Ikeda F, Kumashiro N, Nomiyama T et al (2007) Amelioration
of glucose tolerance by hepatic inhibition of nuclear factor κB in db/db mice. Diabetologia
50(1):131–141
Tang H-Y, Xiao Q-G, Xu H-B, Zhang Y (2015) Hypoglycemic activity and acute oral toxicity of
chromium methionine complexes in mice. J Trace Elem Med Biol 29:136–144
Tarozzi A, Angeloni C, Malaguti M et al (2013) Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. Oxidative Med Cell Longev 2013:1–10. https://
doi.org/10.1155/2013/415078
Tin AS, Park AH, Sundar SN, Firestone GL (2014) Essential role of the cancer stem/progenitor cell
marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast
cancer cells. BMC Biol 12:72
Toohey J, Cooper A (2014) Thiosulfoxide (Sulfane) sulfur: new chemistry and new regulatory
roles in biology. Molecules 19:12789–12813. https://doi.org/10.3390/molecules190812789
Trio PZ, You S, He X et al (2014) Chemopreventive functions and molecular mechanisms of garlic
organosulfur compounds. Food Funct 5(5):833–844
Tsubura A, Lai Y-C, Kuwata M et al (2011) Anticancer effects of garlic and garlic-derived compounds for breast cancer control. Anti Cancer Agents Med Chem 11:249–253
Turos E, Long TE, Konaklieva MI, et al (2002) N-thiolated beta-lactams: novel antibacterial agents
for methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett 12(16):2229–2231.
https://doi.org/10.1016/s0960-894x(02)00343-8
Viswanathan V, Phadatare AG, Mukne A (2014) Antimycobacterial and anti-bacterial activity of
Allium sativum bulbs. Indian J Pharm Sci 76:256–261
Volchegorskiĭ IA, Alekseev MN, Volchegorskaia MI, Rassokhina LM (2008) [Effect of alphalipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome]. Klin Med 86(10):52–59. Retrieved from http://europepmc.org/abstract/
MED/19069461
Waag T, Gelhaus C, Rath J et al (2010) Allicin and derivates are cysteine protease inhibitors with
anti-parasitic activity. Bioorganic Med Chem Lett. https://doi.org/10.1016/j.bmcl.2010.07.062
Wang H-C, Pao J, Lin S-Y, Sheen L-Y (2012) Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Ann N Y Acad Sci 1271:44–52. https://doi.
org/10.1111/j.1749-6632.2012.06743.x
Warshafsky S, Kamer RS, Sivak SL (1993) Effect of garlic on total serum cholesterol: a metaanalysis. Ann Intern Med 119:599–605
21 Health Benefits of Organosulfur Compounds