467
Kim S, Kubec R, Musah RA (2006) Anti-bacterial and anti-fungal activity of sulfur- containing compounds from Petiveria alliacea L. J Ethnopharmacol 104:188–192. https://doi.org/10.1016/j.
jep.2005.08.072
Kim S, Kim D-B, Lee S, Park J, Shin D, Yoo M (2016a) Profiling of organosulphur compounds
using HPLC-PDA and GC/MS system and antioxidant activities in hooker chive (Allium hookeri). Nat Prod Res 30(24):2798–2804
Kim S, Park S-L, Lee S, Lee S-Y, Ko S, Yoo M (2016b) UPLC/ESI-MS/MS analysis of compositional changes for organosulfur compounds in garlic (Allium sativum L.) during fermentation.
Food Chem 211:555–559
Kim S, Kim D-B, Jin W, Park J, Yoon W, Lee Y et al (2018) Comparative studies of bioactive
organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant
garlic (Allium ampeloprasum L.) and onion (Allium cepa L.). Nat Prod Res 32(10):1193–1197
Kimbaris AC, Siatis NG, Daferera DJ, Tarantilis PA, Pappas CS, Polissiou MG (2006) Comparison
of distillation and ultrasound-assisted extraction methods for the isolation of sensitive aroma
compounds from garlic (Allium sativum). Ultrason Sonochem 13(1):54–60
Kourounakis PN, Rekka EA (1991) Effect on active oxygen species of alliin and Allium sativum
(garlic) powder. Res Commun Chem Pathol Pharmacol 74:249–252
Krishna A, Yadav A (2012) Lead compound design for TPR/COX dual inhibition. J Mol Model
18:4397–4408. https://doi.org/10.1007/s00894-012-1435-y
Ku DD, Abdel-Razek TT, Dai J et al (2002) Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin Exp Pharmacol
Physiol 29:84–91. https://doi.org/10.1046/j.1440-1681.2002.03596.x
Kumari K, Augusti KT (2002) Anti-diabetic and antioxidant effects of S-methyl cysteine sulfoxide
isolated from onions (Allium cepa Linn) as compared to standard drugs in alloxan diabetic rats.
Indian J Exp Biol 40(9):1005–1009
Kumari K, Augusti KT (2007) Lipid lowering effect of S-methyl cysteine sulfoxide from Allium
cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 109:367–371. https://doi.
org/10.1016/j.jep.2006.07.045
Lacroix IME, Li-Chan ECY (2014) Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: a natural approach to complement
pharmacotherapy in the management of diabetes. Mol Nutr Food Res
Lai P, Roy J (2012) Anti-microbial and chemopreventive properties of herbs and spices. Curr Med
Chem. https://doi.org/10.2174/0929867043365107
Lai K-C, Kuo C-L, Ho H-C et al (2012) Diallyl sulfide, diallyl disulfide and diallyl trisulfide
affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo.
Phytomedicine 19:625–630. https://doi.org/10.1016/j.phymed.2012.02.004
Lang A (2004) Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory
cytokines and chemokines from intestinal epithelial cells. Clin Nutr 23:1199–1208. https://doi.
org/10.1016/j.clnu.2004.03.011
Lanzotti V, Scala F, Bonanomi G (2014) Compounds from Allium species with cytotoxic and antimicrobial activity. Phytochem Rev 13:769–791. https://doi.org/10.1007/s11101-014-9366-0
Lee HS, Lee CH, Tsai HC, Salter DM (2009) Inhibition of cyclooxygenase 2 expression by diallyl
sulfide on joint inflammation induced by urate crystal and IL-1β. Osteoarthr Cartil. https://doi.
org/10.1016/j.joca.2008.05.010
Lee DY, Li H, Lim HJ et al (2012) Anti-inflammatory activity of sulfur-containing compounds
from garlic. J Med Food 15:992–999. https://doi.org/10.1089/jmf.2012.2275
Lemar KM, Turner MP, Lloyd D (2002) Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts. J Appl Microbiol. https://doi.
org/10.1046/j.1365-2672.2002.01707.x
Lemar KM, Passa O, Aon MA et al (2005) Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans. Microbiology. https://doi.org/10.1099/mic.0.28095-0
Lemar KM, Aon MA, Cortassa S et al (2007) Diallyl disulphide depletes glutathione inCandida albicans: oxidative stress-mediated cell death studied by two-photon microscopy. Yeast
24:695–706. https://doi.org/10.1002/yea.1503
21 Health Benefits of Organosulfur Compounds
Kim S, Kubec R, Musah RA (2006) Anti-bacterial and anti-fungal activity of sulfur- containing compounds from Petiveria alliacea L. J Ethnopharmacol 104:188–192. https://doi.org/10.1016/j.
jep.2005.08.072
Kim S, Kim D-B, Lee S, Park J, Shin D, Yoo M (2016a) Profiling of organosulphur compounds
using HPLC-PDA and GC/MS system and antioxidant activities in hooker chive (Allium hookeri). Nat Prod Res 30(24):2798–2804
Kim S, Park S-L, Lee S, Lee S-Y, Ko S, Yoo M (2016b) UPLC/ESI-MS/MS analysis of compositional changes for organosulfur compounds in garlic (Allium sativum L.) during fermentation.
Food Chem 211:555–559
Kim S, Kim D-B, Jin W, Park J, Yoon W, Lee Y et al (2018) Comparative studies of bioactive
organosulphur compounds and antioxidant activities in garlic (Allium sativum L.), elephant
garlic (Allium ampeloprasum L.) and onion (Allium cepa L.). Nat Prod Res 32(10):1193–1197
Kimbaris AC, Siatis NG, Daferera DJ, Tarantilis PA, Pappas CS, Polissiou MG (2006) Comparison
of distillation and ultrasound-assisted extraction methods for the isolation of sensitive aroma
compounds from garlic (Allium sativum). Ultrason Sonochem 13(1):54–60
Kourounakis PN, Rekka EA (1991) Effect on active oxygen species of alliin and Allium sativum
(garlic) powder. Res Commun Chem Pathol Pharmacol 74:249–252
Krishna A, Yadav A (2012) Lead compound design for TPR/COX dual inhibition. J Mol Model
18:4397–4408. https://doi.org/10.1007/s00894-012-1435-y
Ku DD, Abdel-Razek TT, Dai J et al (2002) Garlic and its active metabolite allicin produce endothelium- and nitric oxide-dependent relaxation in rat pulmonary arteries. Clin Exp Pharmacol
Physiol 29:84–91. https://doi.org/10.1046/j.1440-1681.2002.03596.x
Kumari K, Augusti KT (2002) Anti-diabetic and antioxidant effects of S-methyl cysteine sulfoxide
isolated from onions (Allium cepa Linn) as compared to standard drugs in alloxan diabetic rats.
Indian J Exp Biol 40(9):1005–1009
Kumari K, Augusti KT (2007) Lipid lowering effect of S-methyl cysteine sulfoxide from Allium
cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 109:367–371. https://doi.
org/10.1016/j.jep.2006.07.045
Lacroix IME, Li-Chan ECY (2014) Overview of food products and dietary constituents with antidiabetic properties and their putative mechanisms of action: a natural approach to complement
pharmacotherapy in the management of diabetes. Mol Nutr Food Res
Lai P, Roy J (2012) Anti-microbial and chemopreventive properties of herbs and spices. Curr Med
Chem. https://doi.org/10.2174/0929867043365107
Lai K-C, Kuo C-L, Ho H-C et al (2012) Diallyl sulfide, diallyl disulfide and diallyl trisulfide
affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo.
Phytomedicine 19:625–630. https://doi.org/10.1016/j.phymed.2012.02.004
Lang A (2004) Allicin inhibits spontaneous and TNF-α induced secretion of proinflammatory
cytokines and chemokines from intestinal epithelial cells. Clin Nutr 23:1199–1208. https://doi.
org/10.1016/j.clnu.2004.03.011
Lanzotti V, Scala F, Bonanomi G (2014) Compounds from Allium species with cytotoxic and antimicrobial activity. Phytochem Rev 13:769–791. https://doi.org/10.1007/s11101-014-9366-0
Lee HS, Lee CH, Tsai HC, Salter DM (2009) Inhibition of cyclooxygenase 2 expression by diallyl
sulfide on joint inflammation induced by urate crystal and IL-1β. Osteoarthr Cartil. https://doi.
org/10.1016/j.joca.2008.05.010
Lee DY, Li H, Lim HJ et al (2012) Anti-inflammatory activity of sulfur-containing compounds
from garlic. J Med Food 15:992–999. https://doi.org/10.1089/jmf.2012.2275
Lemar KM, Turner MP, Lloyd D (2002) Garlic (Allium sativum) as an anti-Candida agent: a comparison of the efficacy of fresh garlic and freeze-dried extracts. J Appl Microbiol. https://doi.
org/10.1046/j.1365-2672.2002.01707.x
Lemar KM, Passa O, Aon MA et al (2005) Allyl alcohol and garlic (Allium sativum) extract produce oxidative stress in Candida albicans. Microbiology. https://doi.org/10.1099/mic.0.28095-0
Lemar KM, Aon MA, Cortassa S et al (2007) Diallyl disulphide depletes glutathione inCandida albicans: oxidative stress-mediated cell death studied by two-photon microscopy. Yeast
24:695–706. https://doi.org/10.1002/yea.1503
21 Health Benefits of Organosulfur Compounds