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that daily oral Aloe sterol-containing A. vera gel powder significantly reduced facial
wrinkles in women aged more than or equal to 40 years, and Aloe sterols stimulate
collagen and hyaluronic acid production by human dermal fibroblasts.
Tanaka et al. (2016) performed a randomized, double-blind, placebo-controlled
study for 12-weeks to evaluate the effects of oral Aloe sterol-supplemented yogurt
on skin elasticity, hydration, and the collagen score in 64 healthy women (age range
30–59 years; average 44.3 years). The treated group revealed statistical differences
in skin moisture, trans-epidermal water loss, skin elasticity, and collagen score
between the from placebo groups. The gross elasticity (R2), net elasticity (R5), and
biological elasticity (R7) scores of the Aloe sterol group significantly increased with
time. In addition, skin fatigue area F3, which is known to decrease with age and
fatigue, also increased with Aloe sterol intake. Ultrasound echogenicity revealed
that the collagen content in the dermis increased with Aloe sterol intake. The results
suggest that continued Aloe sterol ingestion contributes to maintaining healthy skin.
Rajashree and Rose (2018) reported an anti-aging gel formulated by blending
three biopolymers which were Collagen (3%w/v), Chitosan (1.5% w/v) and A. vera
gel (0.21% w/v). The prepared gel was characterized by good spreadability and high
hydrophyllicity. Cell culture studies on the mouse fibroblasts cells (NIH3T3) were
carried out using senescence-associated-β-gal as a biomarker. A. vera blended gel
stimulated proliferation rate of the fibroblasts cells (NIH3T3) reversing of the process of senesce. The prepared gel helps in regeneration and rejuvenation of the skin
and is considered as a promising anti-aging gel.
18.5.12 Wound Healing Activity
The sterols present in plants have been reported to exert healing properties thus
justifying the uses of aloe for healing purposes. The sterols are identified to increase
production of the cells of endothelial walls of arteries as they increase the production of proteins important in keeping the integrity of vessels intact (Moon et al.
1999). Furthermore, Aloe vera administration in rats showed that the plant has
wound healing properties as it rids of the bacteria that may enhance the inflammation associated with wounds (Heggers et al. 1995). Also glucomannan and gibberellins cause increase production of collagen by causing increase activity of fibroblasts
when aloe is applied topically or administered orally (Sahu et al. 2013).
Adhikari et al. (2018) validated the antibacterial influence of gel extract of Aloe
barbadensis against multiple antibiotic resistant Pseudomonas aeruginosa that is
responsible for wound development from affected patients. The result obtained
from their study shows that Aloe vera gel could be used for the treatment of multiple
antibiotic resistant Pseudomonas aeruginosa isolated from wound specimen.
Escobar-Sierra and Perea-Mesa (2017) evaluated the capability of chitosan and
polyvinyl alcohol to absorb Aloe vera gel for effective control release in order to
facilitate the rate of healing infected wounds and their effectual healing. The fabrication of the membrane involves different composition which involve Chitosan and
C. Egbuna et al.
that daily oral Aloe sterol-containing A. vera gel powder significantly reduced facial
wrinkles in women aged more than or equal to 40 years, and Aloe sterols stimulate
collagen and hyaluronic acid production by human dermal fibroblasts.
Tanaka et al. (2016) performed a randomized, double-blind, placebo-controlled
study for 12-weeks to evaluate the effects of oral Aloe sterol-supplemented yogurt
on skin elasticity, hydration, and the collagen score in 64 healthy women (age range
30–59 years; average 44.3 years). The treated group revealed statistical differences
in skin moisture, trans-epidermal water loss, skin elasticity, and collagen score
between the from placebo groups. The gross elasticity (R2), net elasticity (R5), and
biological elasticity (R7) scores of the Aloe sterol group significantly increased with
time. In addition, skin fatigue area F3, which is known to decrease with age and
fatigue, also increased with Aloe sterol intake. Ultrasound echogenicity revealed
that the collagen content in the dermis increased with Aloe sterol intake. The results
suggest that continued Aloe sterol ingestion contributes to maintaining healthy skin.
Rajashree and Rose (2018) reported an anti-aging gel formulated by blending
three biopolymers which were Collagen (3%w/v), Chitosan (1.5% w/v) and A. vera
gel (0.21% w/v). The prepared gel was characterized by good spreadability and high
hydrophyllicity. Cell culture studies on the mouse fibroblasts cells (NIH3T3) were
carried out using senescence-associated-β-gal as a biomarker. A. vera blended gel
stimulated proliferation rate of the fibroblasts cells (NIH3T3) reversing of the process of senesce. The prepared gel helps in regeneration and rejuvenation of the skin
and is considered as a promising anti-aging gel.
18.5.12 Wound Healing Activity
The sterols present in plants have been reported to exert healing properties thus
justifying the uses of aloe for healing purposes. The sterols are identified to increase
production of the cells of endothelial walls of arteries as they increase the production of proteins important in keeping the integrity of vessels intact (Moon et al.
1999). Furthermore, Aloe vera administration in rats showed that the plant has
wound healing properties as it rids of the bacteria that may enhance the inflammation associated with wounds (Heggers et al. 1995). Also glucomannan and gibberellins cause increase production of collagen by causing increase activity of fibroblasts
when aloe is applied topically or administered orally (Sahu et al. 2013).
Adhikari et al. (2018) validated the antibacterial influence of gel extract of Aloe
barbadensis against multiple antibiotic resistant Pseudomonas aeruginosa that is
responsible for wound development from affected patients. The result obtained
from their study shows that Aloe vera gel could be used for the treatment of multiple
antibiotic resistant Pseudomonas aeruginosa isolated from wound specimen.
Escobar-Sierra and Perea-Mesa (2017) evaluated the capability of chitosan and
polyvinyl alcohol to absorb Aloe vera gel for effective control release in order to
facilitate the rate of healing infected wounds and their effectual healing. The fabrication of the membrane involves different composition which involve Chitosan and
C. Egbuna et al.