362
In recent times, the pulp of the A. vera, that are free from the peel, were lyophilized and ethanolic extract was obtained via the Soxhlet method. The result emphasized that the extract significantly decreases blood glucose level and improves body
weight, which is attributed to the phytochemical combinations present in the A. vera
pulp extract (Sacan et al. 2017). Likewise, the A. vera leaf powder including dried
latex and gel were macerated at room temperature with ethanol for 72 h to obtain the
phytochemical extract. The result showed that the presence of phenol, saponins and
anthraquinones in the extract were beneficial in enhancing the wound vascularity to
remove dead tissue and increase wound healing ability (Negahdari et al. 2017).
Moreover, the oral administration of A. vera leaf powder extracts proved to be useful in improving the insulin secretion and the function of pancreatic β-cell in
streptozotocin- induced diabetic rates (Noor et al. 2017). Furthermore, the leaf
extracts of A. arborescens has been reported to reduce the blood sugar, where the
phenol compounds present in the extract possess antioxidant activity in the pancreas
and blood to protect islets of Langerhans from the methyl radical from streptozotocin (Beppu et al. 2006). Additionally, the combined leaf (latex and pulp) extract of
plants that belong to genus Aloe such as A. chaboudii, A. inyangensis, A. zebrina,
A. barbadensis, A. pruinosa and A. arborescens × A. barbadensis hybrid is widely
reported to contain phytochemicals that are useful as enhanced antidiabetic agents
(Grčić et al. 2016). Recently, the phytochemical constitution, hypoglycemic potential, antioxidant activity and toxicity of leaf extract of A. lateritia, A. secundiflora
and A. buettneri is investigated. The results emphasized that the extracts are nontoxic to alloxan-induced diabetic mice and the phytochemicals such as phenols,
flavonoids, tannins, steroids, saponins, alkaloids, anthraquinones and carbohydrates
present in the extracts possess hypoglycemic activity (Mbithi et al. 2018; Guessan
and Kouakou 2017).
18.5.9.2 Root Extract
Similar to leaves, root extract of the plants that belong to genus Aloe also possesses
phytochemicals that can act as potential antidiabetic agent. The root extract of Aloe
ferox contains large quantities of phenols and saponins, along with small portions of
flavonoids, flavonols, tannins and alkaloids (Arowosegbe et al. 2012). The presence
of these phytochemicals is already proved to be beneficial in exhibiting antidiabetic
activity via several literatures. The root extract of A. vera and A. barbadensis are
proven to be helpful in stimulating the synthesis and release of insulin, exhibits
insulin secretagogues activity via secretion of pseudoprototinosaponin AIII and prototinosaponins AIII and initiates glucose uptake through enhanced hepatic gluconeogenesis or glycogenolysis (Patel et al. 2012b; Bnouham et al. 2006). In addition,
the ethanol extract of A. barbadensis root has been proven to increase testosterone
and cholesterol concentration depending on the dosage increase, which elevates
their aphrodisiac property and eventually contributes to their antidiabetic property
(Erhabor and Idu 2017). Likewise, the acetone extract of A. pulcherrima roots were
reported to contain three unique phytocompounds such as aloesaponarin I, II and
C. Egbuna et al.
In recent times, the pulp of the A. vera, that are free from the peel, were lyophilized and ethanolic extract was obtained via the Soxhlet method. The result emphasized that the extract significantly decreases blood glucose level and improves body
weight, which is attributed to the phytochemical combinations present in the A. vera
pulp extract (Sacan et al. 2017). Likewise, the A. vera leaf powder including dried
latex and gel were macerated at room temperature with ethanol for 72 h to obtain the
phytochemical extract. The result showed that the presence of phenol, saponins and
anthraquinones in the extract were beneficial in enhancing the wound vascularity to
remove dead tissue and increase wound healing ability (Negahdari et al. 2017).
Moreover, the oral administration of A. vera leaf powder extracts proved to be useful in improving the insulin secretion and the function of pancreatic β-cell in
streptozotocin- induced diabetic rates (Noor et al. 2017). Furthermore, the leaf
extracts of A. arborescens has been reported to reduce the blood sugar, where the
phenol compounds present in the extract possess antioxidant activity in the pancreas
and blood to protect islets of Langerhans from the methyl radical from streptozotocin (Beppu et al. 2006). Additionally, the combined leaf (latex and pulp) extract of
plants that belong to genus Aloe such as A. chaboudii, A. inyangensis, A. zebrina,
A. barbadensis, A. pruinosa and A. arborescens × A. barbadensis hybrid is widely
reported to contain phytochemicals that are useful as enhanced antidiabetic agents
(Grčić et al. 2016). Recently, the phytochemical constitution, hypoglycemic potential, antioxidant activity and toxicity of leaf extract of A. lateritia, A. secundiflora
and A. buettneri is investigated. The results emphasized that the extracts are nontoxic to alloxan-induced diabetic mice and the phytochemicals such as phenols,
flavonoids, tannins, steroids, saponins, alkaloids, anthraquinones and carbohydrates
present in the extracts possess hypoglycemic activity (Mbithi et al. 2018; Guessan
and Kouakou 2017).
18.5.9.2 Root Extract
Similar to leaves, root extract of the plants that belong to genus Aloe also possesses
phytochemicals that can act as potential antidiabetic agent. The root extract of Aloe
ferox contains large quantities of phenols and saponins, along with small portions of
flavonoids, flavonols, tannins and alkaloids (Arowosegbe et al. 2012). The presence
of these phytochemicals is already proved to be beneficial in exhibiting antidiabetic
activity via several literatures. The root extract of A. vera and A. barbadensis are
proven to be helpful in stimulating the synthesis and release of insulin, exhibits
insulin secretagogues activity via secretion of pseudoprototinosaponin AIII and prototinosaponins AIII and initiates glucose uptake through enhanced hepatic gluconeogenesis or glycogenolysis (Patel et al. 2012b; Bnouham et al. 2006). In addition,
the ethanol extract of A. barbadensis root has been proven to increase testosterone
and cholesterol concentration depending on the dosage increase, which elevates
their aphrodisiac property and eventually contributes to their antidiabetic property
(Erhabor and Idu 2017). Likewise, the acetone extract of A. pulcherrima roots were
reported to contain three unique phytocompounds such as aloesaponarin I, II and
C. Egbuna et al.