357
ates the symptoms of oxidative stress-related diseases due to presence of
phytochemicals like aloeresins and 7-hydroxychromones in A. ferox shows strong
antioxidant activity by suppressing the generation of reactive oxygen species and
free radicals (Jones et al. 2002; Jia and Farrow 2005). In literature in vitro antioxidant activity of various Aloe species (A. melanacantha, A. arborescens, A. harlana,
A. ferox, A. saponaria, A. greatheadii var. davyana and A. marlothii) leaf extracts
have been reported (Asamenew et al. 2011; Yoo et al. 2008; Cardarelli et al. 2017).
18.5.5 Anti-ulcer Activity
Worldwide, one of the most common problem which impairs the quality of life is a
chronic disease known as peptic ulcer which is linked to increased mortality and
morbidity. Imbalance between aggressive factors (Helicobacter pylori, bile salts,
chemicals, free radicals, acid, pepsin and pancreatic enzymes) and defensive factors
(mucosa, adherent mucin, prostaglandins and bicarbonate) leads to ulcer formation.
In both humans and animals, A. vera gel has the ability to minimize the gastric
ulcers (Suvitayavat et al. 2004). To promote digestion and in the treatment of peptic
ulcer, extract of A. vera leaf have been generally recommended due to its efficient
antibacterial activity and cytoprotective action. A. vera gel acts as a promising natural antibiotics which inhibit the growth of resistant H. pylori strains (Radha and
Laxmipriya 2015).
A. vera gel extract shows gastro-protective nature as it acts against the aggressive
factors and protects the gastric mucusa from ulceration by increasing the levels of
glycoproteins and resist the attack of proteolytic enzymes. Presence of flavonoids in
A. vera gel ameliorate the glycoprotein abnormalities and stabilize the antioxidant
status of the gastric mucosa (Subramanian et al. 2007).
In pylorus ligated and lumen perfuse rats, hydrochloric acid induced-gastric
mucosa damage and gastric acid secretion was studied after application of varying
doses of ethanol extract of A. vera (Liliaceae) results demonstrate that extract possess gastroprotective activity and gastric acid inhibitory properties at lower concentration (Yusuf et al. 2004). Another study established that a mixed treatment with
sucralfate and A. vera reduced ulcer sizes, gastric inflammation, elongate gastric
glands and enhance epithelial cell proliferation (Eamlamnam et al. 2006).
18.5.6 Anticancer Activity
In the human population one of the most common and lethal malignancies is hepatocellular carcinoma with approximately 550,000 new cases. Aloe species are considered as a source of medicine in rural areas. Shalabi et al. (2015) evaluated the
in vitro anticancer effect of different doses of A. vera and C. comosum extracts
against hepatocellular carcinoma (HepG2) cells. Results signify that both the
18 Aloe Species as Valuable Sources of Functional Bioactives
ates the symptoms of oxidative stress-related diseases due to presence of
phytochemicals like aloeresins and 7-hydroxychromones in A. ferox shows strong
antioxidant activity by suppressing the generation of reactive oxygen species and
free radicals (Jones et al. 2002; Jia and Farrow 2005). In literature in vitro antioxidant activity of various Aloe species (A. melanacantha, A. arborescens, A. harlana,
A. ferox, A. saponaria, A. greatheadii var. davyana and A. marlothii) leaf extracts
have been reported (Asamenew et al. 2011; Yoo et al. 2008; Cardarelli et al. 2017).
18.5.5 Anti-ulcer Activity
Worldwide, one of the most common problem which impairs the quality of life is a
chronic disease known as peptic ulcer which is linked to increased mortality and
morbidity. Imbalance between aggressive factors (Helicobacter pylori, bile salts,
chemicals, free radicals, acid, pepsin and pancreatic enzymes) and defensive factors
(mucosa, adherent mucin, prostaglandins and bicarbonate) leads to ulcer formation.
In both humans and animals, A. vera gel has the ability to minimize the gastric
ulcers (Suvitayavat et al. 2004). To promote digestion and in the treatment of peptic
ulcer, extract of A. vera leaf have been generally recommended due to its efficient
antibacterial activity and cytoprotective action. A. vera gel acts as a promising natural antibiotics which inhibit the growth of resistant H. pylori strains (Radha and
Laxmipriya 2015).
A. vera gel extract shows gastro-protective nature as it acts against the aggressive
factors and protects the gastric mucusa from ulceration by increasing the levels of
glycoproteins and resist the attack of proteolytic enzymes. Presence of flavonoids in
A. vera gel ameliorate the glycoprotein abnormalities and stabilize the antioxidant
status of the gastric mucosa (Subramanian et al. 2007).
In pylorus ligated and lumen perfuse rats, hydrochloric acid induced-gastric
mucosa damage and gastric acid secretion was studied after application of varying
doses of ethanol extract of A. vera (Liliaceae) results demonstrate that extract possess gastroprotective activity and gastric acid inhibitory properties at lower concentration (Yusuf et al. 2004). Another study established that a mixed treatment with
sucralfate and A. vera reduced ulcer sizes, gastric inflammation, elongate gastric
glands and enhance epithelial cell proliferation (Eamlamnam et al. 2006).
18.5.6 Anticancer Activity
In the human population one of the most common and lethal malignancies is hepatocellular carcinoma with approximately 550,000 new cases. Aloe species are considered as a source of medicine in rural areas. Shalabi et al. (2015) evaluated the
in vitro anticancer effect of different doses of A. vera and C. comosum extracts
against hepatocellular carcinoma (HepG2) cells. Results signify that both the
18 Aloe Species as Valuable Sources of Functional Bioactives